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CoALIVE TERMINATED

Coenzyme A – Launch of In Vivo Experiments

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CoALIVE project word cloud

Explore the words cloud of the CoALIVE project. It provides you a very rough idea of what is the project "CoALIVE" about.

disease    fruit    treatment    breaking    model    diseases    expert    underlying    compound    granting    alternative    synthesis    team    opportunity    join    metabolism    expertise    suffering    compounds    world    neurodegeneration    coenzyme    facilities    pkan    commercial    strategy    demonstrated    despite    coa    completion    approval    diverse    patent    valuable    outstanding    recruitment    core    facility    chemical    hire    cellular    therapeutic    kinase    phosphopantetheine    rare    phenotypic    patients    pantothenate    laboratory    pathologies    ground    organism    levels    agency    analytics    recruit    diabetes    contribution    models    hence    orphan    associate    population    alzheimer    evidenced    metabolic    environment    medicinal    protection    manipulate    class    flies    implications    accelerate    forms    reaching    untreatable    tircon    designation    therapeutics    acies    hindered    leaders    labour    market    obstacles    proof    bio    treating    medicines    assays    national    innovation    ed    prior    discovery    innovative    drug    successful    affords   

Project "CoALIVE" data sheet

The following table provides information about the project.

Coordinator
ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO 

Organization address
address: TEHNOLOSKI PARK 21
city: LJUBLJANA
postcode: 1000
website: www.aciesbio.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Slovenia [SI]
 Total cost 74˙750 €
 EC max contribution 74˙750 € (100%)
 Programme 1. H2020-EU.2.3.2.2. (Enhancing the innovation capacity of SMEs)
 Code Call H2020-INNOSUP-02-2016
 Funding Scheme CSA
 Starting year 2017
 Duration (year-month-day) from 2017-09-29   to  2018-09-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO SI (LJUBLJANA) coordinator 74˙750.00

Map

 Project objective

Acies Bio is looking to hire an expert on disease model development – particularly whole organism models in fruit flies – to join our drug discovery team developing 4-phosphopantetheine-related compounds for treating a range of Coenzyme A (CoA) metabolism related pathologies. Acies Bio’s lead compound is able to directly manipulate cellular CoA levels, which addresses the common underlying cause of this class of diseases. High therapeutic potential of this innovative treatment has been demonstrated for pantothenate-kinase-associated neurodegeneration (PKAN) and has resulted in the European Medicines Agency granting our lead compound orphan medicinal product designation. Application of this class of compounds to related diseases forms a core part of our Innovation Strategy, and could have far reaching implications in diverse areas such as numerous rare metabolic diseases, Alzheimer's disease and diabetes. This would not only make treatment available to a wider population of patients, suffering from currently untreatable conditions, but also open new opportunities for Acies Bio. Despite being world leaders in the field of CoA metabolism, as evidenced by our contribution to the TIRCON consortium, prior recruitment of relevant expertise has been hindered by obstacles within the national labour market. Hence, this call affords a valuable opportunity to recruit an Innovation Associate, to evaluate existing models in fruit flies, develop new disease models, implement novel phenotypic assays, and lead a dedicated facility. Acies Bio will provide outstanding coordination and support facilities, state-of-the-art chemical synthesis and analytics laboratory and a research-driven, commercial environment. Successful completion of this crucial step for proof-of-concept in alternative metabolic diseases, will accelerate patent protection and market approval of these ground-breaking therapeutics.

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The information about "COALIVE" are provided by the European Opendata Portal: CORDIS opendata.

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