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Role of individual retinal ganglion cell types in visual computation and behaviors

Total Cost €


EC-Contrib. €






 IndiVISUAL project word cloud

Explore the words cloud of the IndiVISUAL project. It provides you a very rough idea of what is the project "IndiVISUAL" about.

individual    physiological    activation    evoked    region    insights    mouse    superior    compensatory    time    labeled    bodies    photon    tools    eye    morphological    computation    cell    lateral    physiologically    inputs    geniculate    gain    retina    accessory    imaging    activate    convergence    silencing    brain    retinal    expressing    restricted    behaviors    channels    relevance    approximately    colliculus    synaptic    projections    first    transgenic    cortex    streamed    pharmacogenetic    nucleus    vivo    lines    recipient    cells    mosaic    release    circuits    contains    visually    ganglion    terminal    nervous    escape    optogenetic    movements    regions    axonal    head    processed    understand    innate    mechanistic    retino    silence    link    utilizing    neuronal    originating    mediated    functionally    thousands    divergence    terminals    pattern    optic    layers    types    function    selective    visual    cre    behavior    light    discrimination    morphologically   

Project "IndiVISUAL" data sheet

The following table provides information about the project.


Organization address
city: AARHUS C
postcode: 8000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 212˙194.00


 Project objective

The nervous system contains thousands of morphologically and physiologically different neuronal cell types, organized in distinct circuits. Information processed by the retina is streamed into more than 10 retino-recipient brain regions through approximately 20 distinct visual channels, originating in retinal ganglion cell types. One key feature of visual processing is significant convergence and divergence of retinal ganglion cell type inputs to different brain regions. The objective of this proposal is to understand the relevance of this convergence and divergence of visual pathways. Recently, we have identified several Cre transgenic mouse lines in which labeled ganglion cells show a mosaic-like distribution pattern of ganglion cell bodies in the retina and restricted axonal projections in the retino-recipient layers of the lateral geniculate nucleus, superior colliculus, and accessory optic system. Utilizing these new cell-type-labeled mouse lines, we will first characterize the morphological and physiological properties of Cre-expressing cell types. Next, we will silence or activate the synaptic release of individual cell types at a selective terminal region, such as the visual cortex and superior colliculus, using pharmacogenetic and optogenetic tools, and test their effects on light responses by in-vivo two-photon imaging. Finally, we will investigate the effects of silencing and activation of individual synaptic terminals on behaviors that it has been proposed are mediated by specific visual pathways: visual discrimination mediated by the retino-geniculate pathway; innate escape and approach behavior by the superior colliculus; and visually evoked compensatory head and eye movements by the accessory optic pathway. We aim to link, for the first time, individual pathways of ganglion cell type function with visual computation and behavior in order to gain mechanistic insights into how neuronal circuits are functionally organized in our brain.

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The information about "INDIVISUAL" are provided by the European Opendata Portal: CORDIS opendata.

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