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IndiVISUAL

Role of individual retinal ganglion cell types in visual computation and behaviors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IndiVISUAL project word cloud

Explore the words cloud of the IndiVISUAL project. It provides you a very rough idea of what is the project "IndiVISUAL" about.

computation    cells    silence    utilizing    pattern    neuronal    physiologically    mediated    pharmacogenetic    lines    compensatory    relevance    mosaic    originating    cortex    imaging    geniculate    cell    movements    accessory    behavior    eye    restricted    bodies    superior    types    activation    terminals    convergence    cre    insights    individual    morphologically    release    approximately    retino    morphological    streamed    optogenetic    lateral    escape    processed    head    mouse    first    mechanistic    visually    function    channels    brain    link    ganglion    regions    silencing    circuits    terminal    visual    projections    optic    divergence    retina    evoked    light    discrimination    understand    gain    functionally    expressing    transgenic    contains    retinal    photon    tools    thousands    labeled    time    nucleus    synaptic    colliculus    nervous    vivo    behaviors    axonal    inputs    activate    physiological    recipient    innate    selective    region    layers   

Project "IndiVISUAL" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.yoneharalab.com/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 212˙194.00

Map

 Project objective

The nervous system contains thousands of morphologically and physiologically different neuronal cell types, organized in distinct circuits. Information processed by the retina is streamed into more than 10 retino-recipient brain regions through approximately 20 distinct visual channels, originating in retinal ganglion cell types. One key feature of visual processing is significant convergence and divergence of retinal ganglion cell type inputs to different brain regions. The objective of this proposal is to understand the relevance of this convergence and divergence of visual pathways. Recently, we have identified several Cre transgenic mouse lines in which labeled ganglion cells show a mosaic-like distribution pattern of ganglion cell bodies in the retina and restricted axonal projections in the retino-recipient layers of the lateral geniculate nucleus, superior colliculus, and accessory optic system. Utilizing these new cell-type-labeled mouse lines, we will first characterize the morphological and physiological properties of Cre-expressing cell types. Next, we will silence or activate the synaptic release of individual cell types at a selective terminal region, such as the visual cortex and superior colliculus, using pharmacogenetic and optogenetic tools, and test their effects on light responses by in-vivo two-photon imaging. Finally, we will investigate the effects of silencing and activation of individual synaptic terminals on behaviors that it has been proposed are mediated by specific visual pathways: visual discrimination mediated by the retino-geniculate pathway; innate escape and approach behavior by the superior colliculus; and visually evoked compensatory head and eye movements by the accessory optic pathway. We aim to link, for the first time, individual pathways of ganglion cell type function with visual computation and behavior in order to gain mechanistic insights into how neuronal circuits are functionally organized in our brain.

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The information about "INDIVISUAL" are provided by the European Opendata Portal: CORDIS opendata.

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