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A Nano-photoelectric Exosome Biosensor for Point-of-care Diagnosis of Early-stage Cancer

Total Cost €


EC-Contrib. €






 ExoSensor project word cloud

Explore the words cloud of the ExoSensor project. It provides you a very rough idea of what is the project "ExoSensor" about.

industrial    avoiding    unmet    signalling    secondment    round    therapeutics    imaging    clinical    appealing    tumour    molecular    positive    collaborators    diagnostics    novelty    false    cell    printing    prototype    confirm    synergetic    poct    fellowship    transfer    optical    stage    college    researcher    negative    kings    circulating    single    health    universal    thomas    feasibility    hospital    university    exosomes    integrating    mentoring    techniques    exosensor    handling    nanosensing    academic    london    sensitive    fabricate    detection    simultaneous    cardiff    quantitatively    chemistry    validation    biology    exosome    protein    engineering    analytical    quality    diagnosis    st    accurate    resides    reservoir    commercial    final    cancer    gpc1    electrochemical    biosensor    pinpointing    ideal    utmost    interdisplinary    tests    printed    toxicology    microscopy    reliability    accessible    biomarkers    markers    advise    king    portable    seek    disease    dual    easily    marker    training    astrazeneca    nanotechnology    cooperation    monitoring    3d    rapid    animal    platform    samples    creatively    guy    ltd    pancreatic    contributions    valuable    biomarker   

Project "ExoSensor" data sheet

The following table provides information about the project.


Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-11   to  2019-10-10


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Tumour-derived circulating exosomes are an ideal, easily accessible reservoir of cancer biomarkers to assess disease processes. Quantitatively pinpointing exosome tumour markers, a clinical field of an unmet need is appealing, yet challenging. The main objectives of the proposal are to develop an integrated dual-signalling exosome biosensor (ExoSensor) for rapid and specific detection of GPC1 exosomes and fabricate a 3D-printed portable prototype for POCT diagnosis of pancreatic cancer, offering an universal technology for clinical cancer diagnosis through quantitatively monitoring the protein marker of cancer-derived exosomes, in a simple way. The novelty resides in creatively achieving accurate, sensitive, and simultaneous detection of exosomes by integrating two synergetic methods (optical and electrochemical) on one single nanosensing platform, avoiding false positive/negative results to the utmost and ensuring the reliability of tests. This European Fellowship at Kings College London will provide the researcher with advanced technical training in molecular biology, exosome, cancer cell and animal handling, analytical chemistry and microscopy and imaging techniques, as well as academic mentoring in research management. A secondment to Cardiff University will seek and confirm the best possible biomarker(s). Another secondment to the industrial partner AstraZeneca Ltd will offer access to various exosomes research (diagnostics, toxicology and therapeutics) and evaluate the feasibility of commercial transfer if possible. Guy’s, St Thomas, and King’s College Hospital (part of King’s Health Partners) will provide valuable clinical samples for final validation stage. Other collaborators will advise on 3D-printing, pancreatic cancer and biomarkers. These interdisplinary contributions are essential and well-related to the proposal research, fostering high-quality cooperation from biology, chemistry, engineering, nanotechnology and clinical areas the other way round.


year authors and title journal last update
List of publications.
2019 Farid N. Faruqu, Julie Tzu-Wen Wang, Lizhou Xu, Luke McNickle, Eden Ming-Yiu Chong, Adam Walters, Mark Gurney, Aled Clayton, Lesley A. Smyth, Robert Hider, Jane Sosabowski, Khuloud T. Al-Jamal
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
published pages: 1666-1682, ISSN: 1838-7640, DOI: 10.7150/thno.27891
Theranostics 9/6 2020-02-27
2018 Farid N. Faruqu, Lizhou Xu, Khuloud T. Al-Jamal
Preparation of Exosomes for siRNA Delivery to Cancer Cells
published pages: , ISSN: 1940-087X, DOI: 10.3791/58814
Journal of Visualized Experiments 142 2020-02-27

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The information about "EXOSENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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