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New and mature neurons in adult circuits: telling memories apart

Total Cost €


EC-Contrib. €






 NEWRON project word cloud

Explore the words cloud of the NEWRON project. It provides you a very rough idea of what is the project "NEWRON" about.

optical    neuronal    mechanisms    tools    spike    involvement    completion    constantly    interfere    circuit    other    life    representations    trigger    gyrus    inputs    decorrelated    ca2    combines    recordings    manipulate    optogenetic    cell    distinguish    storage    action    encoded    closely    population    pattern    spiking    subthreshold    hippocampal    drive    photon    patterns    generating    potentials    convert    incorporate    memories    overlapping    behaviour    questions    virtual    brain    resemble    behaviours    molecular    representing    born    serve    mature    termed    granule    adult    separation    cellular    function    purpose    animal    newborn    insights    intracellular    supplied    monitor    fundamental    intriguingly    physiological    input    dentate    memory    output    differentially    experiments    how    mouse    combine    synaptic    frontier    selectively    environment    network    suprathreshold    types    small    transform    imaging    causally    suggested    tasks    cells    neurons    navigation   

Project "NEWRON" data sheet

The following table provides information about the project.


Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 1˙498˙955 €
 EC max contribution 1˙498˙955 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙498˙955.00


 Project objective

How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. Intriguingly, during adult life, the dentate gyrus is constantly supplied with new neurons, providing new circuit elements that can incorporate into the neuronal network. How the activity of new adult-born neurons and mature granule cells combines to drive the production and storage of distinct memories represents a new frontier in understanding brain function. However, to determine how these neurons transform similar synaptic input patterns into decorrelated spike output patterns representing distinct memories, we need to monitor and manipulate their subthreshold and suprathreshold activity during behaviour. To address these challenges, we will combine molecular, physiological and optical approaches in the mouse dentate gyrus during navigation in a virtual reality environment. We will use intracellular recordings to assess how hippocampal neurons convert synaptic inputs into spike output, 2-photon Ca2 imaging to monitor population activity in the hippocampal circuit, and optogenetic tools to causally test the involvement of specific cell types. These experiments will allow us to address the following key questions: 1. Which behaviours trigger action potentials in identified newborn and mature dentate gyrus neurons? 2. How do synaptic inputs drive spiking in newborn and mature neurons during behaviour? 3. How are small changes in an environment encoded by synaptic inputs to newborn and mature neurons? 4. Can we differentially manipulate the activity of new and mature cells to selectively interfere with animal behaviour during pattern separation and completion tasks? Understanding the role of new and mature neurons in hippocampal function will provide fundamental insights into the cellular mechanisms of memory formation.


year authors and title journal last update
List of publications.
2019 Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan, Elizabeth Forsythe, Michael C. Wu, Gert Lubec, P. Salinas, Michael Häusser, Philip L. Beales, Sofia Christou-Savina
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
published pages: e3000414, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000414
PLOS Biology 17/9 2019-12-16
2017 Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco, Michael Häusser
Active dendritic integration as a mechanism for robust and precise grid cell firing
published pages: 1114-1121, ISSN: 1097-6256, DOI: 10.1038/nn.4582
Nature Neuroscience 20/8 2019-06-19
2018 Christoph Schmidt-Hieber
How Does a Memory Find Its Neurons?
published pages: 1800189, ISSN: 0265-9247, DOI: 10.1002/bies.201800189
BioEssays 40/11 2019-04-18

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