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RSCHD

Functional dissection of the head-direction circuit in mouse retrosplenial cortex.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RSCHD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.vervaeke-lab.org
 Total cost 196˙400 €
 EC max contribution 196˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 196˙400.00

Map

 Project objective

Head direction (HD) cells provide directional information during spatial navigation and thus act as an internal compass. The goal of this study is to understand how the HD circuit creates a lasting neural trace of transient directional changes. Cells selective for HD have been identified in several brain regions, including the retrosplenial cortex (RSC), and display persistent activity in response to transient vestibular turning cues. Although a well-established theoretical framework proposes an elegant circuitry for achieving this self-sustaining activity, biological evidence for such a circuit is lacking. Studies of HD circuitry have faced significant challenges due to the necessity of functional monitoring at large and small scales in vivo, and precise stimulus control. This study will take advantage of recent advances allowing the targeting of specific cells and their inputs for chronic two-photon imaging in the awake, head-fixed, and passively rotated mouse. Experiments will aim to (1) determine the spatial and temporal organization of HD-tuned responses in RSC, and (2) functionally characterize the presynaptic inputs of HD cells. This information will validate or reject a prominent theory of neural network organization, and provide unprecedented insight into a poorly understood but critical brain function.

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The information about "RSCHD" are provided by the European Opendata Portal: CORDIS opendata.

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