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PRIMASKOTI

PReparing Introduction to MArket of SKOTI (PRIMASKOTI) - a breakthrough solution for real-time studies of cytoskeletal motors at single-molecule resolution

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PRIMASKOTI project word cloud

Explore the words cloud of the PRIMASKOTI project. It provides you a very rough idea of what is the project "PRIMASKOTI" about.

motorization    operate    primaskoti    software    simplify    single    preparation    instruments    glass    machines    flexibility    commercially    throughput    protein    scientific    barriers    broaden    cytoskeletal    cancer    platform    combines    environment    operation    knife    cell    idea    cutting    service    medical    times    division    displacement    mechanical    complete    prepare    optical    ease    resolution    edge    biomolecules    instrument    requirement    experiments    cellular    specialized    contact    force    commercialize    requiring    isolation    imaging    interactions    modular    unprecedented    microscope    designed    molecular    diseases    scope    neurodegeneration    supplemented    probes    hardly    pave    minimize    difficult    commercializing    tool    lower    manipulation    microscopy    solid    engage    automatization    stability    motor    kits    surface    strengths    transport    solution    tweezers    molecule    life    swiss    techniques    ultra    commercialization    sciences    contracts    skoti   

Project "PRIMASKOTI" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙238 €
 EC max contribution 149˙238 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 149˙238.00

Map

 Project objective

The PRIMASKOTI project will prepare the commercialization of SKOTI—the Swiss Knife for Optical Tweezers and Imaging. The scientific instrument SKOTI is designed to measure interactions between single biomolecules with a focus on cytoskeletal molecular machines. SKOTI combines several state-of-the-art microscopy techniques with contact-less mechanical manipulation, so-called optical tweezers. Because of its ultra high stability, SKOTI has its particular strengths in experiments requiring a solid support such as a glass surface. This requirement is often the case for cytoskeletal motor protein studies. Since these molecular machines are key to many essential cellular processes such as transport or cell division, being able to study their interactions is an important step towards understanding diseases such as cancer or neurodegeneration. However, due to the highly specialized knowledge necessary to build and operate such instruments, hardly commercially available, single-molecule experiments are difficult. By commercializing SKOTI, we aim to provide a simple-to-access tool which will broaden the scope of applications and users. SKOTI will provide a modular microscope and optical manipulation platform with unprecedented force- and displacement-resolution, ease of operation through motorization and automatization, flexibility, and overall stability of the system. The key idea is to commercialize a complete solution, where the instrument is supplemented with an isolation from the environment, operation and analysis software, specialized probes, service contracts, and kits for experiments that help to minimize preparation times. This approach will simplify single-molecule experiments, increase throughput, and lower barriers to engage in such studies. In the long term, our novel, cutting-edge research tool for life sciences will provide insight to essential cellular processes and pave the way for new medical approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Gero L. Hermsdorf, Sven A. Szilagyi, Sebastian Rösch, Erik Schäffer
High performance passive vibration isolation system for optical tables using six-degree-of-freedom viscous damping combined with steel springs
published pages: 15113, ISSN: 0034-6748, DOI: 10.1063/1.5060707
Review of Scientific Instruments 90/1 2020-01-27

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The information about "PRIMASKOTI" are provided by the European Opendata Portal: CORDIS opendata.

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