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PRIMASKOTI

PReparing Introduction to MArket of SKOTI (PRIMASKOTI) - a breakthrough solution for real-time studies of cytoskeletal motors at single-molecule resolution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PRIMASKOTI project word cloud

Explore the words cloud of the PRIMASKOTI project. It provides you a very rough idea of what is the project "PRIMASKOTI" about.

idea    stability    resolution    flexibility    knife    surface    biomolecules    machines    strengths    solution    unprecedented    lower    cutting    instruments    throughput    commercialization    simplify    edge    microscopy    complete    specialized    difficult    broaden    life    modular    operate    times    techniques    hardly    cell    prepare    sciences    transport    operation    commercialize    force    medical    isolation    displacement    combines    instrument    skoti    ultra    glass    software    swiss    barriers    microscope    designed    commercializing    manipulation    imaging    division    solid    scope    commercially    supplemented    diseases    minimize    protein    cellular    molecular    single    automatization    environment    platform    experiments    motor    engage    ease    requirement    preparation    service    optical    contracts    mechanical    molecule    pave    contact    requiring    tool    interactions    scientific    primaskoti    cytoskeletal    kits    cancer    motorization    tweezers    probes    neurodegeneration   

Project "PRIMASKOTI" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙238 €
 EC max contribution 149˙238 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 149˙238.00

Map

 Project objective

The PRIMASKOTI project will prepare the commercialization of SKOTI—the Swiss Knife for Optical Tweezers and Imaging. The scientific instrument SKOTI is designed to measure interactions between single biomolecules with a focus on cytoskeletal molecular machines. SKOTI combines several state-of-the-art microscopy techniques with contact-less mechanical manipulation, so-called optical tweezers. Because of its ultra high stability, SKOTI has its particular strengths in experiments requiring a solid support such as a glass surface. This requirement is often the case for cytoskeletal motor protein studies. Since these molecular machines are key to many essential cellular processes such as transport or cell division, being able to study their interactions is an important step towards understanding diseases such as cancer or neurodegeneration. However, due to the highly specialized knowledge necessary to build and operate such instruments, hardly commercially available, single-molecule experiments are difficult. By commercializing SKOTI, we aim to provide a simple-to-access tool which will broaden the scope of applications and users. SKOTI will provide a modular microscope and optical manipulation platform with unprecedented force- and displacement-resolution, ease of operation through motorization and automatization, flexibility, and overall stability of the system. The key idea is to commercialize a complete solution, where the instrument is supplemented with an isolation from the environment, operation and analysis software, specialized probes, service contracts, and kits for experiments that help to minimize preparation times. This approach will simplify single-molecule experiments, increase throughput, and lower barriers to engage in such studies. In the long term, our novel, cutting-edge research tool for life sciences will provide insight to essential cellular processes and pave the way for new medical approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Gero L. Hermsdorf, Sven A. Szilagyi, Sebastian Rösch, Erik Schäffer
High performance passive vibration isolation system for optical tables using six-degree-of-freedom viscous damping combined with steel springs
published pages: 15113, ISSN: 0034-6748, DOI: 10.1063/1.5060707
Review of Scientific Instruments 90/1 2020-01-27

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The information about "PRIMASKOTI" are provided by the European Opendata Portal: CORDIS opendata.

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