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Mitogression SIGNED

Generating yeast biodiversity by mitochondrial introgression for wine innovation

Total Cost €


EC-Contrib. €






 Mitogression project word cloud

Explore the words cloud of the Mitogression project. It provides you a very rough idea of what is the project "Mitogression" about.

genome    play    fermentation    genetic    beneficial    supervisor    cerevisiae    molded    bioinformatics    flavors    entity    evolution    career    acceptance    shift    yeasts    demands    wine    mitochondrial    alcohol    modified    isolates    industry    microbiology    commercial    diversity    decrease    strains    foreign    wants    generation    facilities    gmos    researcher    wild    synthetic    expose    organisms    traits    companies    match    limited    saccharomyces    supporting    species    public    decreasing    cultural    genomes    ethanol    speciation    deal    transfer    position    background    global    gained    independent    engineering    form    select    gmo    answer    consolidate    scientific    obtain    evolutionary    cybrids    expectations    leader    experiments    organoleptic    hybrids    generating    community    genetically    starting    collaborations    questions    material    yeast    experimental    demand    ancestors    biodiversity    content    perfect    mainly    preferences    biology    industrial    societies    company    host    mitogression    genotype    basic   

Project "Mitogression" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Wine global demand is decreasing due to a shift in consumer preferences and cultural changes. The EU is a GLOBAL LEADER in WINE production, whose wine companies wants to decrease ethanol content, while improving organoleptic properties to deal with these new demands. YEASTS, mainly Saccharomyces cerevisiae, play a KEY ROLE during wine fermentation, when alcohol and the main flavors are produced. Application of new yeasts, produced by genetic engineering, is limited due to the non-acceptance of Genetically Modified Organisms (GMOs). We PROPOSE to apply non-GMO methodologies, to obtain IMPROVED YEASTS by the generation of yeast strains (cybrids), with mitochondrial genomes (mitogression) from non-cerevisiae species, or hybrids, increasing yeast DIVERSITY, to select strains whose fermentation products match wine company expectations. We will ANSWER some BASIC research QUESTIONS: how is genotype molded by the presence of a foreign mitochondrial genome? Are these changes common between independent experiments and wild isolates? And, are evolved strains starting to show evidence of speciation from their ancestors? The results of this project will IMPACT the WINE INDUSTRY by generating new potential commercial strains, and future collaborations. The knowledge gained through this proposal will demonstrate to the scientific community the use of novel methodologies as well as expose the general public to the importance of biodiversity for industrial processes and how the transfer of genetic material and experimental evolution can produce beneficial traits for our societies. The researcher (evolutionary biology and bioinformatics background), supervisor (microbiology, systems biology, and synthetic biology background), and host institution (facilities, knowledge, experience, and supporting elements) will form a perfect entity for the development of MITOGRESSION proposal, and to CONSOLIDATE the scientific career of the researcher for his future INDEPENDENT position.


year authors and title journal last update
List of publications.
2019 Xueying C. Li, David Peris, Chris Todd Hittinger, Elaine A. Sia, Justin C. Fay
Mitochondria-encoded genes contribute to evolution of heat and cold tolerance in yeast
published pages: eaav1848, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav1848
Science Advances 5/1 2020-04-08
2019 Ramírez-Aroca L, Peris D
Influencia del genoma mitocondrial en el fenotipo de híbridos interespecíficos durante condiciones industrialesInfluence of mitochondrial genome in the phenotype of interspecific hybrids during industrial conditions
published pages: , ISSN: , DOI:
Master Thesis 2020-04-08
2019 Quinn K. Langdon, David Peris, EmilyClare P. Baker, Dana A. Opulente, Huu-Vang Nguyen, Ursula Bond, Paula Gonçalves, José Paulo Sampaio, Diego Libkind, Chris Todd Hittinger
Fermentation innovation through complex hybridization of wild and domesticated yeasts
published pages: , ISSN: 2397-334X, DOI: 10.1038/s41559-019-0998-8
Nature Ecology & Evolution 21/10/2019 2020-04-08
2019 EmilyClare P. Baker, David Peris, Ryan V. Moriarty, Xueying C. Li, Justin C. Fay, Chris Todd Hittinger
Mitochondrial DNA and temperature tolerance in lager yeasts
published pages: eaav1869, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav1869
Science Advances 5/1 2020-04-08
2018 Quinn K Langdon, David Peris, Brian Kyle, Chris Todd Hittinger
sppIDer: A Species Identification Tool to Investigate Hybrid Genomes with High-Throughput Sequencing
published pages: , ISSN: 0737-4038, DOI: 10.1093/molbev/msy166
Molecular Biology and Evolution 01/09/2018 2020-04-08
2017 David Peris, Roberto Pérez-Torrado, Chris Todd Hittinger, Eladio Barrio, Amparo Querol
On the origins and industrial applications of Saccharomyces cerevisiae x Saccharomyces kudriavzevii hybrids
published pages: , ISSN: 0749-503X, DOI: 10.1002/yea.3283
Yeast 12/10/2017 2020-04-08

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The information about "MITOGRESSION" are provided by the European Opendata Portal: CORDIS opendata.

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