Opendata, web and dolomites

WallWatchers SIGNED

Plant cell wall communication and remodelling: the wall watchers.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 WallWatchers project word cloud

Explore the words cloud of the WallWatchers project. It provides you a very rough idea of what is the project "WallWatchers" about.

combining    activation    plant    sensed    ray    components    reverse    uniformly    crops    arabidopsis    powerful    clear    agonists    ultimate    tissue    uncover    genetically    interactions    provides    function    arranged    phenotypes    vivo    receptors    ligands    environment    distributed    force    dynamic    organisms    sensosomes    quantitative    families    signal    multicellular    modified    coordinated    act    atomic    downstream    potentially    pairs    mechanic    status    perceive    relevance    biochemistry    cells    wall    homoeostasis    membrane    plants    animals    expansion    extracellular    metabolic    crystallography    interaction    antagonists    planta    validate    layer    structure    alter    mechanosensors    mechanism    mode    contrast    models    signalling    animal    protein    validated    cell    surrounded    biology    genetics    carbohydrate    binding    rigid    chemical    constantly    poorly    microscopy    biological    tools    sensing    receptor    division    interfere    ligand   

Project "WallWatchers" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙966 €
 EC max contribution 1˙499˙966 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙966.00

Map

 Project objective

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agonists and antagonists, which will represent powerful tools to alter cell wall homoeostasis in Arabidopsis, and potentially in crops.

 Publications

year authors and title journal last update
List of publications.
2019 Steven Moussu, Julia Santiago
Structural biology of cell surface receptor–ligand interactions
published pages: 38-45, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2019.07.001
Current Opinion in Plant Biology 52 2020-03-05
2020 Pedro Jimenez-Sandoval, Julia Santiago
In vitro analytical approaches to study plant ligand-receptor interactions
published pages: pp.01396.2019, ISSN: 0032-0889, DOI: 10.1104/pp.19.01396
Plant Physiology 2020-03-05
2018 Moussu, S.; Augustin, S.; Roman, A.O.; Broyart, C.; Santiago, J.
Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction.
published pages: 671-680, ISSN: 2059-7983, DOI: 10.1101/251959
Acta Crystallographica. Section D, Structural Biology 1 2019-03-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "WALLWATCHERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "WALLWATCHERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

CURVE-X (2019)

Industrialisation of curved sensors and related imagers

Read More  

TRUST (2018)

Truth and Semantics

Read More