Opendata, web and dolomites

WallWatchers SIGNED

Plant cell wall communication and remodelling: the wall watchers.

Total Cost €


EC-Contrib. €






 WallWatchers project word cloud

Explore the words cloud of the WallWatchers project. It provides you a very rough idea of what is the project "WallWatchers" about.

status    biological    validate    cell    homoeostasis    alter    downstream    antagonists    pairs    uncover    microscopy    extracellular    perceive    act    interaction    metabolic    sensed    chemical    dynamic    coordinated    animals    agonists    combining    force    plants    sensing    protein    clear    phenotypes    uniformly    wall    families    genetically    contrast    carbohydrate    expansion    relevance    interactions    tissue    ligands    ultimate    ray    mechanism    crops    mechanosensors    multicellular    crystallography    mode    vivo    arabidopsis    signal    signalling    constantly    rigid    interfere    reverse    sensosomes    powerful    membrane    biochemistry    arranged    tools    animal    ligand    division    atomic    mechanic    provides    planta    components    receptors    layer    surrounded    function    biology    structure    environment    potentially    quantitative    models    cells    modified    activation    validated    genetics    organisms    receptor    distributed    poorly    plant    binding   

Project "WallWatchers" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙966 €
 EC max contribution 1˙499˙966 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙966.00


 Project objective

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agonists and antagonists, which will represent powerful tools to alter cell wall homoeostasis in Arabidopsis, and potentially in crops.


year authors and title journal last update
List of publications.
2019 Steven Moussu, Julia Santiago
Structural biology of cell surface receptor–ligand interactions
published pages: 38-45, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2019.07.001
Current Opinion in Plant Biology 52 2020-03-05
2020 Pedro Jimenez-Sandoval, Julia Santiago
In vitro analytical approaches to study plant ligand-receptor interactions
published pages: pp.01396.2019, ISSN: 0032-0889, DOI: 10.1104/pp.19.01396
Plant Physiology 2020-03-05
2018 Moussu, S.; Augustin, S.; Roman, A.O.; Broyart, C.; Santiago, J.
Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction.
published pages: 671-680, ISSN: 2059-7983, DOI: 10.1101/251959
Acta Crystallographica. Section D, Structural Biology 1 2019-03-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "WALLWATCHERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "WALLWATCHERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DINAMIX (2019)

Real-time diffusion NMR analysis of mixtures

Read More  

SiMS (2019)

Simulated Majorana states

Read More  

EAST (2020)

Using Evolutionary Algorithms to Understand and Secure Web/Enterprise Systems

Read More