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WallWatchers SIGNED

Plant cell wall communication and remodelling: the wall watchers.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 WallWatchers project word cloud

Explore the words cloud of the WallWatchers project. It provides you a very rough idea of what is the project "WallWatchers" about.

plants    animal    receptor    tissue    signal    function    sensing    mechanism    clear    ultimate    distributed    genetics    antagonists    constantly    validate    biochemistry    ligand    signalling    arabidopsis    modified    biological    mechanosensors    phenotypes    expansion    pairs    organisms    agonists    ray    status    families    layer    atomic    components    interactions    membrane    plant    biology    force    relevance    contrast    models    mechanic    interfere    surrounded    binding    cells    tools    metabolic    crops    uniformly    environment    combining    receptors    cell    animals    potentially    coordinated    vivo    multicellular    powerful    homoeostasis    sensosomes    uncover    planta    extracellular    poorly    chemical    perceive    dynamic    mode    wall    arranged    provides    downstream    carbohydrate    alter    genetically    act    rigid    interaction    reverse    structure    protein    quantitative    validated    ligands    crystallography    division    sensed    microscopy    activation   

Project "WallWatchers" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙966 €
 EC max contribution 1˙499˙966 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙966.00

Map

 Project objective

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agonists and antagonists, which will represent powerful tools to alter cell wall homoeostasis in Arabidopsis, and potentially in crops.

 Publications

year authors and title journal last update
List of publications.
2019 Steven Moussu, Julia Santiago
Structural biology of cell surface receptor–ligand interactions
published pages: 38-45, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2019.07.001
Current Opinion in Plant Biology 52 2020-03-05
2020 Pedro Jimenez-Sandoval, Julia Santiago
In vitro analytical approaches to study plant ligand-receptor interactions
published pages: pp.01396.2019, ISSN: 0032-0889, DOI: 10.1104/pp.19.01396
Plant Physiology 2020-03-05
2018 Moussu, S.; Augustin, S.; Roman, A.O.; Broyart, C.; Santiago, J.
Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction.
published pages: 671-680, ISSN: 2059-7983, DOI: 10.1101/251959
Acta Crystallographica. Section D, Structural Biology 1 2019-03-18

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The information about "WALLWATCHERS" are provided by the European Opendata Portal: CORDIS opendata.

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