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FocAd SIGNED

Structural Studies on Focal Adhesions

Total Cost €

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EC-Contrib. €

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Partnership

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 FocAd project word cloud

Explore the words cloud of the FocAd project. It provides you a very rough idea of what is the project "FocAd" about.

ultrastructural    complexes    tension    learned    structural    tested    microscopy    players    mass    integrin    force    clarified    aggressive    cryo    ray    regulation    hence    cell    light    governing    unclear    fundamental    combination    ligand    mechanisms    triggered    fa    hybrid    observe    cutting    hierarchical    biology    spectrometry    tackle    implicated    transduce    stepwise    membranes    developmental    actin    leads    basis    regarding    focal    living    sensing    cancers    signaling    transferred    polarization    environment    sophisticated    molecular    expertise    employ    techniques    cells    lessons    platform    assembly    crystallography    components    machinery    counteracting    protein    survival    emerged    outside    purified    sensitive    questions    fas    gigantic    macromolecular    em    defects    points    assemblies    core    recombinant    fashion    systematic    innovative    behavior    anchoring    migration    contributes    biochemical    biophysical    cytoskeletons    cytoskeleton    super    adhesions    reconstitutions    edge    medically    activation    initiating    networks    function    detrimental   

Project "FocAd" data sheet

The following table provides information about the project.

Coordinator		 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 1˙999˙998 €
 EC max contribution 1˙999˙998 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙999˙998.00

Map

 Project objective

Focal adhesions (FA) are gigantic protein complexes whose formation is triggered by integrin ligand activation. FAs represent (1) a sensing platform and anchoring points to the outside environment and, (2) a machinery to transduce this information by initiating signaling pathways for cell growth, survival, migration and polarization. Failure in the regulation of FA leads to developmental defects and contributes to the formation of aggressive cancers. Hence, understanding FA formation is the basis for counteracting these detrimental effects. Recently, mass spectrometry and advanced light microscopy clarified players involved in the FA assembly and implicated sophisticated regulation networks of membranes and actin cytoskeletons in the growth of FAs. However, the molecular mechanisms of FA formation and signaling still remain unclear. We propose to study the molecular mechanisms governing the growth of FA by bottom-up reconstitutions using purified recombinant protein components. We will employ a systematic and hierarchical assembly of the FA machinery on an integrin platform as well as on an actin cytoskeleton in a stepwise fashion. We will use a combination of cutting-edge techniques of hybrid structural biology (cryo-EM and X-ray crystallography), light microscopy and biochemical/biophysical approaches. Our core expertise is cryo-EM, which has emerged as the method of choice to study the molecular mechanisms of (super-)macromolecular assemblies. Furthermore, we will set up a system to observe the behavior of tension-sensitive FA components in the presence of force under cryo-EM. Finally, lessons learned from our biochemical and ultrastructural analysis will be directly transferred and tested in living cells. Using these innovative methods, we will tackle fundamental and medically relevant questions regarding the assembly and function of FAs.

 Publications

year authors and title journal last update
List of publications.
2019 Dirk Dedden, Stephanie Schumacher, Charlotte F. Kelley, Martin Zacharias, Christian Biertümpfel, Reinhard Fässler, Naoko Mizuno
The Architecture of Talin1 Reveals an Autoinhibition Mechanism
published pages: 120-131.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.08.034 		Cell 179/1 2019-12-17

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