Explore the words cloud of the SYMCELLS project. It provides you a very rough idea of what is the project "SYMCELLS" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||2˙272˙485 €|
|EC max contribution||2˙272˙485 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-06-01 to 2022-05-31|
Take a look of project's partnership.
|1||RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG||DE (HEIDELBERG)||coordinator||2˙272˙485.00|
Many cells stably integrate microbes to gain ecological advantages for the organism. A remarkable example is the symbiosis between corals and algae, whose provision of photosynthetically fixed nutrients enables coral survival in nutrient-poor habitats. To establish symbiosis, coral cells acquire symbionts via phagocytosis, a process often used for pathogen clearance in other animals. Symbionts reside in phagosomes, and the prevailing view is that, similar to some pathogens, symbionts avoid destruction via phagolysosomal manipulation. Yet, unlike pathogens, symbionts provide nutrients to their host, and this may be key for intracellular persistence. Most research on nutrient translocation has focused on sugars, but surprisingly, sterols may be significant because cnidarians cannot synthesize cholesterol. However, little is known about the underlying molecular mechanisms of symbiosis establishment. Because corals are intractable cell biological models, I will leverage our unique resources and expertise to uncover fundamental aspects of symbiont acquisition and metabolic dependence using the emerging model anemone Aiptasia. To investigate symbiont acquisition (Objective 1), I will distinguish symbiont-phagocytosing cells, test candidate symbiont receptors by gain- and loss-of-function, record symbiont/cell interactions by live-imaging, and generate a symbiosis cell culture system. To understand the significance of symbiont-derived sterols (Objective 2), I will map cellular sterol utilization and identify the sterol transport machinery, test whether symbiont sterols can functionally substitute cholesterol, identify novel sterol-interacting proteins by pull-down assays, and explore symbiont persistence mechanisms using comparative phagosome proteomics. This proposal will for the first time provide a mechanistic understanding of coral-algal symbiosis establishment, a crucial process underpinning coral reefs, economically and ecologically important ecosystems.
|year||authors and title||journal||last update|
Marie R. Jacobovitz, Sebastian Rupp, Philipp A. Voss, Sebastian G. Gornik, Annika Guse
Dinoflagellate symbionts escape vomocytosis by host cell immune suppression
published pages: , ISSN: , DOI: 10.1101/864579
Victor A. S. Jones, Madeline Bucher, Elizabeth A. Hambleton, Annika Guse
Microinjection to deliver protein, mRNA, and DNA into zygotes of the cnidarian endosymbiosis model Aiptasia sp.
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34773-1
|Scientific Reports 8/1||2019-05-27|
Elizabeth Hambleton, Arnold Shivas Jones, Ira Maegele, David Kvaskoff, Timo Sachsenheimer, Annika Guse
Enhanced Stability of Non-Canonical NPC2 in the symbiosome supports coral-algal symbiosis
published pages: , ISSN: , DOI: 10.1101/399766
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