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BICEPSvsHIV

Novel strategies for anti-HIV-1 therapy: Small molecules targeting RNA partners of the nucleocapsid protein

Total Cost €

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EC-Contrib. €

0

Partnership

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 BICEPSvsHIV project word cloud

Explore the words cloud of the BICEPSvsHIV project. It provides you a very rough idea of what is the project "BICEPSvsHIV" about.

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Project "BICEPSvsHIV" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
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email: n.a.
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 Coordinator Country Italy [IT]
 Project website https://www.unipd.it/en/success-stories-msca-research-fellowships
 Total cost 164˙203 €
 EC max contribution 164˙203 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 164˙203.00
2    THE STATE UNIVERSITY OF NEW YORK US (ALBANY NY) partner 0.00

Map

 Project objective

European Commission considers HIV/AIDS as a top priority and significantly invests in research devoted to the development of alternative therapeutic strategies leading to new antiretrovirals, which are urgently needed to overcome the emergence of resistance to existing drugs.

The “BICEPSvsHIV” project proposes a novel and innovative strategy that draws the spotlight on RNA. Specific RNA sequences of the viral genome are substrates of the HIV-1 nucleocapsid (NC), a highly conserved protein known for promoting remodeling of nucleic acid structures in essential steps of the virus replication cycle. The proposed strategy consists in the employment of bis-3-chloropiperidines (BICEPS) as RNA cross-linking agents able to freeze selectively the tridimensional conformations of the RNA partners of NC, thus impairing its activities.

RNA is a challenging molecule from the medicinal chemistry perspective, but the rewards it can yield are invaluable. The Experienced Researcher (ER) will work at The RNA Institute (SUNY Albany) during the outgoing phase, aimed at 1) the elucidation of BICEPS detailed molecular mechanism of reaction towards RNA and 2) the identification of BICEPS targeting selectively the RNA substrates of NC. During the incoming phase at the University of Padova (UNIPD), the achievements will be translated into 3) the thorough biological evaluation of the in vitro NC inhibition by BICEPS, leading to 4) the identification of anti-NC lead compounds.

The project provides the ER with an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific profile with new excellent skills. The training includes both scientific and transferable skills, aimed at the reinforcement of the ER professional maturity and independence and at the establishment of long-term international collaborations.

 Publications

year authors and title journal last update
List of publications.
2019 Caterina Carraro, Alexander Francke, Alice Sosic, Franziska Kohl, Tim Helbing, Michele De Franco, Daniele Fabris, Richard Göttlich, Barbara Gatto
Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents
published pages: 552-557, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00580
ACS Medicinal Chemistry Letters 10/4 2020-01-21
2018 Alice Sosic, Irene Saccone, Caterina Carraro, Thomas Kenderdine, Elia Gamba, Giuseppe Caliendo, Angela Corvino, Paola Di Vaio, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Valentina Spada, Dan Fabris, Francesco Frecentese, Barbara Gatto
Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins
published pages: 2195-2207, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00104
Bioconjugate Chemistry 29/7 2020-01-21
2018 Alice Sosic, Botros Toro, Richard Goettlich, Pan T.X. Li, Barbara Gatto, Dan Fabris
A New Beautiful Friendship: Solution Thermal Melting and Nanospray-MS for the Characterization of Intermolecular Conjugates Produced by Bifunctional Crosslinking
published pages: , ISSN: , DOI:
66th ASMS Conference on Mass Spectrometry and Allied Topics 2020-01-21

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