BICEPSvsHIV
Novel strategies for anti-HIV-1 therapy: Small molecules targeting RNA partners of the nucleocapsid protein
Total Cost €
0EC-Contrib. €
0Partnership
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Project "BICEPSvsHIV" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI PADOVA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | https://www.unipd.it/en/success-stories-msca-research-fellowships |
| Total cost | 164˙203 € |
| EC max contribution | 164˙203 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-07-01 to 2019-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI PADOVA | IT (PADOVA) | coordinator | 164˙203.00 |
| 2 | THE STATE UNIVERSITY OF NEW YORK | US (ALBANY NY) | partner | 0.00 |
Map
Project objective
European Commission considers HIV/AIDS as a top priority and significantly invests in research devoted to the development of alternative therapeutic strategies leading to new antiretrovirals, which are urgently needed to overcome the emergence of resistance to existing drugs.
The “BICEPSvsHIV” project proposes a novel and innovative strategy that draws the spotlight on RNA. Specific RNA sequences of the viral genome are substrates of the HIV-1 nucleocapsid (NC), a highly conserved protein known for promoting remodeling of nucleic acid structures in essential steps of the virus replication cycle. The proposed strategy consists in the employment of bis-3-chloropiperidines (BICEPS) as RNA cross-linking agents able to freeze selectively the tridimensional conformations of the RNA partners of NC, thus impairing its activities.
RNA is a challenging molecule from the medicinal chemistry perspective, but the rewards it can yield are invaluable. The Experienced Researcher (ER) will work at The RNA Institute (SUNY Albany) during the outgoing phase, aimed at 1) the elucidation of BICEPS detailed molecular mechanism of reaction towards RNA and 2) the identification of BICEPS targeting selectively the RNA substrates of NC. During the incoming phase at the University of Padova (UNIPD), the achievements will be translated into 3) the thorough biological evaluation of the in vitro NC inhibition by BICEPS, leading to 4) the identification of anti-NC lead compounds.
The project provides the ER with an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific profile with new excellent skills. The training includes both scientific and transferable skills, aimed at the reinforcement of the ER professional maturity and independence and at the establishment of long-term international collaborations.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Caterina Carraro, Alexander Francke, Alice Sosic, Franziska Kohl, Tim Helbing, Michele De Franco, Daniele Fabris, Richard Göttlich, Barbara Gatto Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents published pages: 552-557, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00580 |
ACS Medicinal Chemistry Letters 10/4 | 2020-01-21 |
| 2018 |
Alice Sosic, Irene Saccone, Caterina Carraro, Thomas Kenderdine, Elia Gamba, Giuseppe Caliendo, Angela Corvino, Paola Di Vaio, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Valentina Spada, Dan Fabris, Francesco Frecentese, Barbara Gatto Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins published pages: 2195-2207, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00104 |
Bioconjugate Chemistry 29/7 | 2020-01-21 |
| 2018 |
Alice Sosic, Botros Toro, Richard Goettlich, Pan T.X. Li, Barbara Gatto, Dan Fabris A New Beautiful Friendship: Solution Thermal Melting and Nanospray-MS for the Characterization of Intermolecular Conjugates Produced by Bifunctional Crosslinking published pages: , ISSN: , DOI: |
66th ASMS Conference on Mass Spectrometry and Allied Topics | 2020-01-21 |
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