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CODE4Vision SIGNED

Computational Dissection of Effective Circuitry and Encoding in the Retina for Normal and Restored Vision

Total Cost €

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EC-Contrib. €

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Partnership

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 CODE4Vision project word cloud

Explore the words cloud of the CODE4Vision project. It provides you a very rough idea of what is the project "CODE4Vision" about.

reconstructing    code    connectivity    closed    artificial    presynaptic    nonlinear    degeneration    adjust    supplemented    output    brain    restoration    optogenetic    patients    dynamical    signalling    simultaneous    designing    layout    neurons    proteins    ganglion    deciphering    understanding    derive    loop    computational    code4vision    excitatory    encode    vision    cell    mouse    recreating    thorough    inputs    parallel    stimulus    lies    optogenetics    statistics    network    implants    operations    sensitive    neuronal    direct    represented    encodes    therapies    experiments    neuroscience    encoding    dynamics    streams    electronic    cells    stimulation    circuits    recordings    pave    emulate    tackle    neural    models    populations    emerge    stimuli    light    bipolar    diverse    learning    visual    retina    schemes    transmission    types    retinal    suffering    automatically    photoreceptors    fundamental    machine    layers    connections    natural    inserted   

Project "CODE4Vision" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS 

Organization address
address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙991˙445 €
 EC max contribution 1˙991˙445 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS DE (GOETTINGEN) coordinator 1˙991˙445.00

Map

 Project objective

Understanding how neural circuits process and encode information is a fundamental goal in neuroscience. For the neural network of the retina, such knowledge is also of concrete importance for the development of vision restoration therapies for patients suffering from degeneration of photoreceptors. Artificial stimulation of retinal neurons through electronic implants or inserted light-sensitive proteins (“optogenetics”) aims at reconstructing natural transmission of visual information to the brain. Recreating natural retinal activity, however, will require a thorough understanding of the complex and diverse neural code of the retina. The challenge lies in deciphering the various nonlinear operations and dynamics in the around 30 parallel signalling streams that emerge from the retina, represented by as many types of ganglion cells, the retina’s output neurons.

The CODE4Vision project will tackle this challenge by identifying the effective connectivity between the different types of retinal ganglion cells and their excitatory presynaptic partners, bipolar cells, and by determining the features of information processing between these neuronal layers. We will characterize the layout of bipolar cell inputs to large populations of ganglion cells with novel analyses that we derive from computational statistics and machine learning. We will then study the nonlinear and dynamical features of these connections by designing closed-loop experiments that automatically adjust visual stimuli to the identified layout of bipolar cells. These analyses will be supplemented by direct measurements of connections through simultaneous bipolar and ganglion cell recordings. The results will pave the way towards new models of how the retina encodes natural visual stimuli. Finally, we will apply this knowledge to mouse models of optogenetic vision restoration in order to develop stimulation schemes that emulate natural retinal stimulus encoding.

 Publications

year authors and title journal last update
List of publications.
2019 Norma Krystyna Kühn, Tim Gollisch
Activity Correlations between Direction-Selective Retinal Ganglion Cells Synergistically Enhance Motion Decoding from Complex Visual Scenes
published pages: 963-976.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.003
Neuron 101/5 2019-06-11
2017 Jian K. Liu, Helene M. Schreyer, Arno Onken, Fernando Rozenblit, Mohammad H. Khani, Vidhyasankar Krishnamoorthy, Stefano Panzeri, Tim Gollisch
Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization
published pages: 149/1-149/14, ISSN: 2041-1723, DOI: 10.1038/s41467-017-00156-9
Nature Communications 8/1 2019-06-12
2017 Mohammad Hossein Khani, Tim Gollisch
Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells
published pages: 3024-3043, ISSN: 0022-3077, DOI: 10.1152/jn.00529.2017
Journal of Neurophysiology 118/6 2019-05-15
2017 Sebastian Bemme, Michael Weick, Tim Gollisch
Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception
published pages: 4754, ISSN: 0146-0404, DOI: 10.1167/iovs.17-21572
Investigative Opthalmology & Visual Science 58/11 2019-05-15

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The information about "CODE4VISION" are provided by the European Opendata Portal: CORDIS opendata.

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