Explore the words cloud of the BIONICS project. It provides you a very rough idea of what is the project "BIONICS" about.
The following table provides information about the project.
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
|Coordinator Country||Italy [IT]|
|Total cost||168˙277 €|
|EC max contribution||168˙277 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-05-01 to 2020-04-30|
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|1||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||coordinator||168˙277.00|
Ischemic stroke occurs due to reduced perfusion to a brain region, because of the blockage of a blood vessel, resulting in death or permanent neurological deficits. It presents high percentages of mortality and morbidity worldwide and market analysis in five major EU countries showed that the total number of first-ever incidents of stroke cases will rise to 1.63 million (43.7% growth) by 2034. Although, many treatments that make use of therapeutic nanoparticles have been presented, unfortunately to date, no effective treatment has been found to prevent damage to the ischemic brain after stroke. Oxidative stress is related to the pathogenesis of stroke and overproduction of ROS and RNS are thought to be the main cause of this. In addition, the overproduction of MMP-9 has been related to many post-stroke side effects. Thus, I propose the development of a biomimetic and neuroprotective lipid nanocapsule (BIONICS) for the targeted treatment of post-stroke side effects. BIONICS will safely deliver anti-oxidant nanoparticles (CeO2) and iNOS inhibitors (L-NIL) across the BBB aiming at reducing the overproduced ROS, RNS and MMP-9, resulting in to the amelioration of the neurological deficits caused by oxidative stress. Through this project, the new skills in the synthesis of antioxidant nanocapsules, the use of molecular biology techniques, design and fabrication of microfluidic models, project management, grant writing, and other transferable skills that I will acquire in IIT, will help my future career plans providing knowledge and expertise in a field where my knowledge is limited. This action will also give me the opportunity to transfer my pre-gained knowledge through seminars/workshops to the institution where my research will be carried out. Overall, I believe that BIONICS will have a significant impact on my short and long-term career goals and will bring me one step closer to my impending goal of the independent researcher.
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The information about "BIONICS" are provided by the European Opendata Portal: CORDIS opendata.
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