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BIONICS SIGNED

A biomimetic and neuroprotective delivery nanocapsule for the targeted treatment of post-ischemic stroke effects

Total Cost €

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EC-Contrib. €

0

Partnership

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 BIONICS project word cloud

Explore the words cloud of the BIONICS project. It provides you a very rough idea of what is the project "BIONICS" about.

nil    independent    worldwide    me    transfer    transferable       death    plans    biomimetic    vessel    limited    career    give    microfluidic    brain    lipid    presented    mmp    bbb    damage    unfortunately    date    perfusion    43    impending    antioxidant    ischemic    models    treatment    action    fabrication    thought    showed    researcher    inos    believe    bionics    oxidant    mortality    incidents    countries    molecular    neuroprotective    caused    pathogenesis    nanoparticles    blood    region    million    techniques    safely    grant    reducing    post    neurological    opportunity    oxidative    ing    workshops    seminars    blockage    deficits    acquire    occurs    63    overproduced    amelioration    therapeutic    writing    expertise    first    iit    2034    closer    prevent    total    gained    ros    skills    overproduction    market    ceo2    goals    synthesis    permanent    nanocapsule    rns    percentages    stress    morbidity    treatments    found    stroke    nanocapsules    biology    inhibitors    anti   

Project "BIONICS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 168˙277.00

Map

 Project objective

Ischemic stroke occurs due to reduced perfusion to a brain region, because of the blockage of a blood vessel, resulting in death or permanent neurological deficits. It presents high percentages of mortality and morbidity worldwide and market analysis in five major EU countries showed that the total number of first-ever incidents of stroke cases will rise to 1.63 million (43.7% growth) by 2034. Although, many treatments that make use of therapeutic nanoparticles have been presented, unfortunately to date, no effective treatment has been found to prevent damage to the ischemic brain after stroke. Oxidative stress is related to the pathogenesis of stroke and overproduction of ROS and RNS are thought to be the main cause of this. In addition, the overproduction of MMP-9 has been related to many post-stroke side effects. Thus, I propose the development of a biomimetic and neuroprotective lipid nanocapsule (BIONICS) for the targeted treatment of post-stroke side effects. BIONICS will safely deliver anti-oxidant nanoparticles (CeO2) and iNOS inhibitors (L-NIL) across the BBB aiming at reducing the overproduced ROS, RNS and MMP-9, resulting in to the amelioration of the neurological deficits caused by oxidative stress. Through this project, the new skills in the synthesis of antioxidant nanocapsules, the use of molecular biology techniques, design and fabrication of microfluidic models, project management, grant writing, and other transferable skills that I will acquire in IIT, will help my future career plans providing knowledge and expertise in a field where my knowledge is limited. This action will also give me the opportunity to transfer my pre-gained knowledge through seminars/workshops to the institution where my research will be carried out. Overall, I believe that BIONICS will have a significant impact on my short and long-term career goals and will bring me one step closer to my impending goal of the independent researcher.

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The information about "BIONICS" are provided by the European Opendata Portal: CORDIS opendata.

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