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INTERSPINE

From Neurons to Robots: Non-Invasive, General-Purpose Interfacing With Human Spinal Motor Neurons

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EC-Contrib. €

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Project "INTERSPINE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 150˙000.00

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 Project objective

INTERSPINE (“From Neurons to Robots: Non-Invasive, General-Purpose Interfacing With Human Spinal Motor Neurons”) aims at exploiting the methodologies developed during the ERC Advanced grant DEMOVE (“Decoding the Neural Code of Human Movements for a New Generation of Man-machine Interfaces”). During DEMOVE, novel bioelectrodes and computational methods have been developed to enrich our fundamental understanding of the mechanisms underlying the generation of human movements, from the cellular level to the function. These methods also contributed to the development of new schemes for controlling bionic limbs to substitute missing ones in amputees. INTERSPINE will translate these methods, and specifically those based on non-implanted electrodes, to develop a more robust general system that extracts neural information (at the individual cell level) from the human spinal cord and transforms it into extremely accurate commands to external devices, such as prosthesis, general purpose and teleoperated robots, and computer interfaces. This will be the only non-invasive man-machine interface based on direct neural activity (spiking of neural cells). The ERC Grant DEMOVE demonstrated in laboratory conditions that this approach is feasible and allows the identification of the exact timing of each activation of neural cells in the spinal cord, known as motor neurons. INTERSPINE will extend this approach through wearable devices and real-time processing, as well as with a robust association between the identified neural activity and external commands to devices, with the aim of revolutionizing everyday man-machine interfacing. The direct decoding of neural activity will provide unprecedented accuracy and robustness with respect to other non-invasive approaches.

Keywords: man-machine interfacing; motor neurons; electromyography (EMG); prosthesis; movement; spinal cord; muscles; motor control.

 Publications

year authors and title journal last update
List of publications.
2018 A. Del Vecchio, F. Negro, D. Falla, I. Bazzucchi, D. Farina, F. Felici
Higher muscle fiber conduction velocity and early rate of torque development in chronically strength-trained individuals
published pages: 1218-1226, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.00025.2018
Journal of Applied Physiology 125/4 2019-10-08
2018 A. Del Vecchio, A. Úbeda, M. Sartori, J. M. Azorín, F. Felici, D. Farina
Central nervous system modulates the neuromechanical delay in a broad range for the control of muscle force
published pages: 1404-1410, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.00135.2018
Journal of Applied Physiology 125/5 2019-10-08
2018 EDUARDO MARTINEZ-VALDES, DARIO FARINA, FRANCESCO NEGRO, ALESSANDRO DEL VECCHIO, DEBORAH FALLA
Early Motor Unit Conduction Velocity Changes to High-Intensity Interval Training versus Continuous Training
published pages: 2339-2350, ISSN: 0195-9131, DOI: 10.1249/mss.0000000000001705
Medicine & Science in Sports & Exercise 50/11 2019-10-08
2019 Silvia Muceli, Konstantin D Bergmeister, Klaus-Peter Hoffmann, Martin Aman, Ivan Vukajlija, Oskar C Aszmann, Dario Farina
Decoding motor neuron activity from epimysial thin-film electrode recordings following targeted muscle reinnervation
published pages: 16010, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aaed85
Journal of Neural Engineering 16/1 2019-10-08
2017 Dario Farina, Anna Margherita Castronovo, Ivan Vujaklija, Agnes Sturma, Stefan Salminger, Christian Hofer, Oskar Aszmann
Common Synaptic Input to Motor Neurons and Neural Drive to Targeted Reinnervated Muscles
published pages: 11285-11292, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1179-17.2017
The Journal of Neuroscience 37/46 2019-10-08
2019 Alessandro Del Vecchio, Francesco Negro, Ales Holobar, Andrea Casolo, Jonathan P. Folland, Francesco Felici, Dario Farina
You are as fast as your motor neurons: speed of recruitment and maximal discharge of motor neurons determine the maximal rate of force development in humans
published pages: 2445-2456, ISSN: 0022-3751, DOI: 10.1113/jp277396
The Journal of Physiology 597/9 2019-06-06

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