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CINK TERMINATED

Advancing cancer immunotherapy using natural killer cells for hematological and metastatic cancers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CINK project word cloud

Explore the words cloud of the CINK project. It provides you a very rough idea of what is the project "CINK" about.

transplantation    portion    explored    efficacy    cellular    evasion    express    dependent    stem    nca    translated    inhibitory    ab    binding    time    tumor    action    shown    signals    limited    rates    antibodies    benefit    hematological    suppression    multiple    expanded    stimulating    strategies    activation    combination    shp1    limiting    limits    nk    mab    potentially    blockade    relapse    function    consequently    cell    amount    coated    cd137    anti    versatility    costimulation    therapy    induction    cytotoxicty    improvement    cells    combining    ncf    explore    types    heterogeneity    tremendously    stronger    intrinsic    cancer    hypothesize    cancers    transfer    sustained    mechanisms    leukemias    aggressive    monoclonal    antibody    adcc    adoptive    immunregulatory    unstable    impacted    date    myeloma    negatively    fc    clinic    combine    immunotherapy    hsct    metastatic    therapies    cd16    treatment    il12    frame    lymphomas    molecule    expression    ing    hematopoietic    intensively   

Project "CINK" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

Organization address
address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008
website: www.cima.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-15   to  2020-02-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) coordinator 158˙121.00

Map

 Project objective

The development of monoclonal antibodies (mAb) to target tumor cells has tremendously improve cancer immunotherapy and benefit the treatment of aggressive cancer such as some types of lymphomas, leukemias, multiple myeloma and metastatic cancers. One of the mechanisms of action is the induction of antibody-dependent cellular cytotoxicty (ADCC) through the activation of CD16 on NK cells after binding to the Fc portion of Ab-coated tumor cells. Therefore, strategies that combine NK cell activation and mAb therapy has been intensively explored. However, tumor heterogeneity and unstable expression of the targeted molecule in the tumor cells limits ADCC for mAb therapy resulting in cancer relapse. Furthermore, intrinsic NK immunregulatory mechanisms as well as NK-specific tumor evasion mechanisms have also negatively impacted the use of NK cell-based therapies. In this proposal we will explore the mechanisms involved in the reduced NK cell function (NCF) observed after ADCC and/or NK cell activation (NCA) in order to develop novel strategies to achieve a sustained and stronger NCF by combining stimulating signals with suppression of inhibitory signals such as costimulation via CD137 and IL12, or SHP1/2 blockade. We hypothesize that the adoptive transfer (AT) of NK cells expanded by this novel method will result in better anti-tumor responses after mAb therapy even in tumor cells that express limited amount of the target molecule and limiting consequently cancer relapse rates. Furthermore, due to the overall improvement on NCF, we expect that the combination of AT NK cells with hematopoietic stem cell transplantation (HSCT) will also increase anti-tumor responses; which efficacy up to date has shown to be rather limited. Given the versatility of our approach, this therapy can be used for the treatment of many cancers, but particularly hematological and metastatic cancers and potentially can be translated into the clinic in a short time frame.

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The information about "CINK" are provided by the European Opendata Portal: CORDIS opendata.

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