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VASCFORM SIGNED

Deformable vascular registration for co-mapping altered hemodynamics with vascular responses,and for introducing a new measure for aneurysm rupture risk assessment: the local surfacegrowth

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VASCFORM project word cloud

Explore the words cloud of the VASCFORM project. It provides you a very rough idea of what is the project "VASCFORM" about.

quantify    deformable    maximum    marker    patients    vascular    media    metric    microenvironment    relationship    risk    sacrifice    localized    mice    co    lesion    associate    animal    introduce    obtain    model    size    rupture    fast    groundwork    3d    aneurysm    measured    regions    angiotensin    responsible    aortic    infused    performed    tear    exact    indirectly    difficult    disturbed    data    direct    sensitive    answer    degree    microscopic    uniform    consecutive    justification    asaa    remodeling    corresponding    identification    points    fluid    expansion    ascending    outcome    quantification    effect    images    tools    time    growth    correspondence    wall    hemodynamic    computational    initiation    registration    hemodynamics    baseline    clinical    meshes    surface    geometry    stage    leads    correlate    pathology    local    map    apoe    suspected    methodology    questions    reflects    rate    mechanics    potentially    regional    initiating    lastly    debated    histological    diameter   

Project "VASCFORM" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.

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The information about "VASCFORM" are provided by the European Opendata Portal: CORDIS opendata.

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