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VASCFORM SIGNED

Deformable vascular registration for co-mapping altered hemodynamics with vascular responses,and for introducing a new measure for aneurysm rupture risk assessment: the local surfacegrowth

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VASCFORM project word cloud

Explore the words cloud of the VASCFORM project. It provides you a very rough idea of what is the project "VASCFORM" about.

relationship    stage    mice    size    points    tear    justification    consecutive    asaa    sensitive    measured    patients    surface    initiation    mechanics    identification    expansion    ascending    outcome    apoe    3d    introduce    vascular    wall    angiotensin    local    localized    aortic    computational    quantify    regional    histological    marker    answer    risk    metric    associate    suspected    meshes    performed    media    initiating    registration    direct    hemodynamic    debated    effect    rate    maximum    remodeling    uniform    quantification    diameter    sacrifice    difficult    hemodynamics    exact    microenvironment    pathology    fast    map    tools    co    geometry    rupture    methodology    groundwork    leads    aneurysm    reflects    time    correspondence    data    corresponding    indirectly    microscopic    clinical    responsible    animal    deformable    growth    disturbed    correlate    obtain    lesion    baseline    degree    potentially    images    lastly    questions    fluid    regions    model    infused   

Project "VASCFORM" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.

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The information about "VASCFORM" are provided by the European Opendata Portal: CORDIS opendata.

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