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EU-TRAIN SIGNED

The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EU-TRAIN" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 6˙641˙546 €
 EC max contribution 6˙641˙546 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2017-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙025˙447.00
2    CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES FR (NANTES) participant 1˙207˙741.00
3    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 1˙154˙520.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 898˙236.00
5    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 750˙597.00
6    UNIVERSITE DE GENEVE CH (GENEVE) participant 444˙413.00
7    INSERM TRANSFERT SA FR (PARIS) participant 391˙875.00
8    OXFORD IMMUNOTEC LIMITED UK (ABINGDON) participant 303˙841.00
9    CELLTREND GESELLSCHAFT MIT BESCHRANKTER HAFTUNG DE (LUCKENWALDE) participant 208˙313.00
10    EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION NL (AMSTERDAM) participant 120˙000.00
11    CERNER FRANCE FR (PUTEAUX) participant 96˙563.00
12    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 40˙000.00

Map

 Project objective

Rejection is the major cause of allograft failure with dramatic consequences in terms of mortality, morbidity and increased cost for the society. The field of transplantation lacks a robust assessment of risk stratification. Thus, it impairs the development of relevant clinical trials to address graft and patient outcomes. We formed the EU-TRAIN project by gathering reference kidney transplant centres in a fully operating European network including 12 partners. Our ambitious but realistic goals are: to provide clinicians with innovative and accessible tools for early prediction of individual risk of allograft rejection and transplant loss; to personalise clinical management and treatment and; to improve allograft outcomes. This project will engineer a risk stratification system applied to kidney transplant patients by analysing the integration of several layers of data (clinical, histological, immunological data as well as gene expression and novel biomarkers) - the TRAnsplant Comprehensive Evaluator of Risk (EU-TRACER). EU-TRACER will be generated and validated in 2 dedicated studies including a randomised control trial. Translation to patients will be achieved by delivering: 1) A multiplex non-invasive biomarker system for the stratification and immune monitoring of low and high risk kidney recipients; 2) A prognostic system for individual risk stratification for allograft rejection and failure that will assist decision making via an interactive web interface. The EU-TRACER, developed with our 3 industrial partners, will define a new standard of care in transplantation. The EU-TRACER will have the potential for a large implementation and diffusion in other centres in Europe and will be suitable for industrial collaboration.

 Deliverables

List of deliverables.
Communication and Dissemination tools Websites, patent fillings, videos etc. 2020-04-07 22:49:49

Take a look to the deliverables list in detail:  detailed list of EU-TRAIN deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Nuria Montero, Samira Farouk, Ilaria Gandolfini, Elena Crespo, Marta Jarque, Maria Meneghini, Alba Torija, Umberto Maggiore, Paolo Cravedi, Oriol Bestard
Pretransplant Donor-specific IFNγ ELISPOT as a Predictor of Graft Rejection
published pages: e451, ISSN: 2373-8731, DOI: 10.1097/txd.0000000000000886
Transplantation Direct 5/5 2020-04-07

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The information about "EU-TRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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