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Hepatocarcinoma IVM

Spatiotemporal dynamics of CD8+ T cell responses to hepatocellular carcinoma

Total Cost €


EC-Contrib. €






Project "Hepatocarcinoma IVM" data sheet

The following table provides information about the project.


Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 168˙277.00


 Project objective

CD8 T cells have a key role in eliminating tumors that affect the liver. The protective capacity of these cells relies on their ability to migrate to the liver, recognize antigens and deploy effector functions. While some of the rules that characterize CD8 T cell behavior in the cancerous liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8 T cell conduct at the single-cell level. In preliminary data for this project we have developed advanced imaging techniques that allow us to dissect the interactive behavior of CD8 T cells within the mouse liver at an unprecedented level of spatial and temporal resolution. We predict that this approach, combined with a new model of hepatocellular carcinoma created ad hoc, will generate novel mechanistic insights into the spatiotemporal determinants that govern the capacity of CD8 T cells to home and function in the tumor-bearing liver.

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The information about "HEPATOCARCINOMA IVM" are provided by the European Opendata Portal: CORDIS opendata.

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