Explore the words cloud of the InflammaTENSION project. It provides you a very rough idea of what is the project "InflammaTENSION" about.
The following table provides information about the project.
UNIVERSITY OF GLASGOW
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙957˙573 €|
|EC max contribution||1˙957˙573 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-05-01 to 2022-04-30|
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|1||UNIVERSITY OF GLASGOW||UK (GLASGOW)||coordinator||1˙957˙573.00|
Hypertension is a common disease impacting 1 billion people worldwide, which leads to catastrophic cardiovascular complications. The cause of primary hypertension is unknown and the disease remains uncontrolled in many patients. By interrogating the key hypothesis that inflammatory dysregulation fundamentally controls development of hypertension and vascular remodelling, InflammaTENSION provides a new paradigm for the management of the disease, with the potential to lead to identification of novel therapeutic targets to control hypertension. InflammaTENSION will result in the discovery of novel biomarkers, capable of identifying patients who could benefit from such immune targeted therapies. Importantly, we already made the seminal observation that the immune system not only mediates target organ damage, but is essential for the development of hypertension. This finding has initiated numerous studies, that defined the roles of pro-inflammatory T cells, monocytes and anti-inflammatory T regulatory cells. However, our current knowledge remains very fragmented and so far has not been applied to human pathology. InflammaTENSION will for the first time advance the knowledge procured in rodent models into human studies. By combining clinical translational and model mechanistic studies it will identify novel inflammatory factors that can control immune mechanisms of hypertension. We will: (1) characterize the immunophenotypic signature of human hypertension; (2) define key concepts in cytokine biology of hypertension with TNF-α and IL-6 as key exemplars; (3) understand how chronic cytokines regulate the T cell dependent mechanisms of hypertension. InflammaTENSION will go beyond current state-of-the-art through comprehensive combination of immunology and cardiovascular medicine to create a new understanding of how the immune system may lead to human hypertension and will have major impact on the field, enabling translation of these exciting findings to clinical practice.
|year||authors and title||journal||last update|
Tomasz J Guzik
Heterogenous treatment effects: secrets for a reliable treat-to-target trial?
published pages: e18-e20, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx081
|Cardiovascular Research 113/7||2019-05-15|
Pasquale Maffia, Tomasz J Guzik
When, where, and how to target vascular inflammation in the post-CANTOS era?
published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehz133
|European Heart Journal||2019-05-15|
Pawel Maga, Tomasz P. Mikolajczyk, Lukasz Partyka, Mateusz Siedlinski, Mikolaj Maga, Marek Krzanowski, Krzysztof Malinowski, Kevin Luc, Rafal Nizankowski, Deepak L. Bhatt, Tomasz J. Guzik
Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo
published pages: 26-33, ISSN: 1521-6616, DOI: 10.1016/j.clim.2018.06.006
|Clinical Immunology 194||2019-05-15|
Tomasz J. Guzik, Francesco Cosentino
Epigenetics and Immunometabolism in Diabetes and Aging
published pages: 257-274, ISSN: 1523-0864, DOI: 10.1089/ars.2017.7299
|Antioxidants & Redox Signaling 29/3||2019-05-15|
Marta Czesnikiewicz-Guzik, Ryszard Nosalski, Tomasz P Mikolajczyk, Francesca Vidler, Tomasz Dohnal, Elzbieta Dembowska, Delyth Graham, David G Harrison, Tomasz J Guzik
Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction
published pages: , ISSN: 0007-1188, DOI: 10.1111/bph.14536
|British Journal of Pharmacology||2019-05-15|
Tomasz P. Mikolajczyk, Ryszard Nosalski, Dominik S. Skiba, Joanna Koziol, Magdalena Mazur, Amauri S. Justoâ€Junior, Paulina Kowalczyk, Zofia Kusmierczyk, Agata Schrammâ€Luc, Kevin Luc, Pasquale Maffia, Delyth Graham, Anna K. Kiss, Marek Naruszewicz, Tomasz J. Guzik
1,2,3,4,6â€Pentaâ€ O â€galloylâ€Î²â€ d â€glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin IIâ€induced hypertension
published pages: , ISSN: 0007-1188, DOI: 10.1111/bph.14583
|British Journal of Pharmacology 2019 Jan 18||2019-05-15|
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