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M-DrivE TERMINATED

Metabolic Drivers of Epigenetic Modifications: metabolic inducers of histone post-translational modifications in a biological setting

Total Cost €

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EC-Contrib. €

0

Partnership

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 M-DrivE project word cloud

Explore the words cloud of the M-DrivE project. It provides you a very rough idea of what is the project "M-DrivE" about.

doses    modifications    characterised    disorder    intracellular    shown    demonstrating    native    acies    progress    function    modification    expertise    electrostatically    vehicle    lack    efficient    metabolic    highlighting    serum    natural    recognise    combining    dr    inducing    synthesising    exploited    tools    cellular    coa    synthesis    histone    biochemical    epigenetics    upregulate    precursor    metabolomics    cell    international    metabolism    organism    enzyme    proteins    acylations    form    interplay    places    dna    appropriate    bio    backgrounds    probe    position    translational    enrichment    advantage    induction    donor    sole    remove    demonstration    post    epigenetic    rare    chemical    add    substrate    therapeutic    interactions    metabolically    storage    previously    subsequent    expression    derivatives    diverse    acetylation    first    bypassing    gene    coenzyme    sekirnik    route    implication    illuminate    influence    enzymes    protein    complementarity    permeable    phosphopantetheine    units    model    partnership    prolific    acetyl    stable    substrates    acyl    genetic    unexplored    realise    tolerated    affording    rapid    species    endogenous    ppt    faulty   

Project "M-DrivE" data sheet

The following table provides information about the project.

Coordinator
ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO 

Organization address
address: TEHNOLOSKI PARK 21
city: LJUBLJANA
postcode: 1000
website: www.aciesbio.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Slovenia [SI]
 Total cost 157˙287 €
 EC max contribution 157˙287 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO SI (LJUBLJANA) coordinator 157˙287.00

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 Project objective

Post-translational chemical modifications to histone proteins – the storage units of DNA – influence gene expression electrostatically and through specific protein-protein interactions, the study of which is known as epigenetics. Although many enzymes have been identified which add, remove or recognise these modifications, the implication of metabolism in the induction of epigenetic states is a recent development – particularly highlighting acetyl coenzyme A (CoA) as the sole donor for acetylation. Due to the lack of appropriate biochemical tools, this emerging field has not yet been exploited, however Acies Bio’s leading work on the efficient synthesis of 4’ phosphopantetheine (4-PPT), a natural precursor of the prolific substrate CoA, places us in a unique position to realise the novel approach of metabolically inducing epigenetic modifications. In progress towards therapeutic use bypassing faulty metabolism in a rare genetic disorder, we have shown that 4-PPT is cell permeable, serum-stable, tolerated at high doses without side-effects, and can also upregulate histone acetylation. This presents a previously unexplored route to develop 4-PPT as a novel vehicle for the delivery of diverse intracellular acyl-CoA species, and subsequent histone modification. Taking advantage of the interplay between metabolic and epigenetic states, and the complementarity of backgrounds that Acies Bio and Dr Sekirnik can provide through an international partnership combining expertise in both fields, our proposed work would illuminate recently characterised histone acylations. By synthesising novel 4-PPT derivatives, and demonstrating their activity on a cellular and model organism level, we will develop new tools to enable rapid enrichment of rare endogenous modifications to probe their function. This would form the first demonstration of use of native enzyme substrates to affect epigenetic states, affording new European research opportunities in both metabolomics and epigenetics.

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The information about "M-DRIVE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2025-07-17 8:14:08) correctly updated