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Post-translational modifications during floral initiation: molecular dissection of the UFO-dependent LFY activation

Total Cost €


EC-Contrib. €






 PFIMDULA project word cloud

Explore the words cloud of the PFIMDULA project. It provides you a very rough idea of what is the project "PFIMDULA" about.

fellow    poorly    expertise    lfy    modifications    network    re    sectors    functional    model    animal    activation    leafy    governing    e3    centers    ubiquitination    group    biochemistry    background    dependent    biology    enforce    grenoble    genetics    plants    notably    plant    technologies    successful    human    residues    flowers    structural    ligase    planta    orchestrated    industry    ptm    post    skills    combined    maturity    emphasis    environment    inflorescences    spectrometry    arabidopsis    food    french    modify    assayed    complementary    box    function    academia    cullin    ufo    employment    interacting    translational    gene    degradation    facilities    proteins    special    ubiquitin    interaction    master    builds    flowering    outstanding    organisms    professional    mechanism    principles    acquire    throughput    developmental    crystallography    mass    basis    elusive    architecture    skp1    transcription    multidisciplinary    regulatory    flower    understand    earth   

Project "PFIMDULA" data sheet

The following table provides information about the project.


Organization address
address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-08   to  2019-06-07


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Flowering plants are the most successful plant group on Earth and provide the basis for most human and animal food. The development of flowers is dependent on a gene regulatory network orchestrated by LEAFY (LFY), the master transcription factor. In Arabidopsis as in other flowering plants, LFY activity is dependent upon its interaction with UFO, a member of the Skp1–Cullin–F-box E3 ubiquitin ligase complex. The goal of this project is to understand why LFY requires interacting with UFO to build flowers. For this, we will apply state-of-the-art technologies including mass-spectrometry, crystallography, biochemistry and plant developmental genetics to identify and characterize the function of Post-Translational Modifications (PTM) on LFY or LFY interacting proteins, with special emphasis on ubiquitination. After identifying key residues involved in the LFY-UFO interaction or targeted by PTM, their functional importance will be assayed in planta. This project should facilitate better understanding of the mechanism of LFY activation. LEAFY and the development of flower will be used here as a model to understand the “activation by degradation” mechanism, still elusive in most organisms and poorly studied in plants. Moreover, understanding the principles governing LFY activation should provide means to modify at will the architecture of plant inflorescences. This project builds on the current background of the applicant in the field of Mass-Spectrometry combined with the outstanding expertise at Grenoble and high-throughput facilities in Structural biology and plant developmental genetics. Notably, the applicant will work within one of the top French Research Centers and in a multidisciplinary environment that will allow the fellow to acquire complementary ‘new knowledge and skills’ in structural biology and developmental genetics. This will re-enforce the fellow’s background and professional maturity for employment opportunities in both academia and industry sectors.


year authors and title journal last update
List of publications.
2018 Claudius Marondedze, Xinyun Liu, Shihui Huang, Cynthia Wong, Xuan Zhou, Xutong Pan, Huiting An, Nuo Xu, Xuechen Tian, Aloysius Wong
Towards a tailored indoor horticulture: a functional genomics guided phenotypic approach
published pages: , ISSN: 2052-7276, DOI: 10.1038/s41438-018-0065-7
Horticulture Research 5/1 2019-08-05

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