Opendata, web and dolomites

CFZEBRA

Balancing the immune response in cystic fibrosis: using zebrafish models of infection and inflammation to uncover new therapeutic approaches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CFZEBRA project word cloud

Explore the words cloud of the CFZEBRA project. It provides you a very rough idea of what is the project "CFZEBRA" about.

disease    cell    human    elucidate    pathophysiology    conductance    genetic    suggest    functions    severe    active    mucociliary    infective    infection    disorder    persistent    combined    context    lack    expression    immune    fellowship    found    imaging    mutations    limiting    larvae    expectancy    microenvironment    consequent    alterations    tractable    data    transmembrane    innate    lung    correcting    models    accompanied    dynamic    pulmonary    mortality    caused    cftr    lines    cf    inflammation    patients    pathology    susceptibility    therapies    quality    model    chronic    defects    confirm    innovative    primary    physiological    gives    life    zebrafish    dominated    abnormalities    suitable    benefit    morbidity    gene    cystic    molecules    balance    progressive    infections    macrophages    guide    techniques    neutrophil    pathogens    improvement    preliminary    therapeutic    injury    unmet    limited    deficient    causes    deficiency    regulating    fibrosis    inflammatory    regulator    animal    larval    function    recapitulate   

Project "CFZEBRA" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 195˙454.00

Map

 Project objective

Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Chronic pulmonary infections accompanied by persistent neutrophil-dominated inflammation result in severe progressive lung injury and are the leading causes of morbidity and mortality of CF patients. In addition to known mucociliary defects, several lines of evidence suggest primary alterations in innate immune responses contribute to CF pathology. Currently, our understanding is limited by the lack of suitable animal models that recapitulate immune abnormalities found in CF patients. To address these unmet needs, I propose to develop zebrafish larvae as a tractable animal model to investigate the role of CFTR in regulating inflammation and infection. In preliminary data, reduced zebrafish cftr expression is characterized by more inflammation and increased susceptibility to infection with CF pathogens. In this fellowship, I will use this innovative model to recapitulate aspects of the CF microenvironment. Using innovative genetic techniques combined with dynamic imaging, I will elucidate physiological functions of CFTR in innate immune pathophysiology in CF and identify new therapeutic molecules active in a CFTR-deficient context to balance infection and inflammation to benefit patients with CF. Finally, I will confirm my findings in human CF macrophages. Using larval zebrafish gives a unique insight into immune cell function in CFTR deficiency. This will help guide future therapies aimed at correcting the innate susceptibility of CF patients to infective and inflammatory lung disease, with consequent improvement of their life quality and expectancy.

 Publications

year authors and title journal last update
List of publications.
2018 A. Bernut, A. Floto, S. Renshaw
WS04.6 Balancing the immune response in cystic fibrosis: using zebrafish models of inflammation to uncover new therapeutic approaches
published pages: S8-S9, ISSN: 1569-1993, DOI: 10.1016/s1569-1993(18)30142-5
Journal of Cystic Fibrosis 17 2019-11-08
2019 Audrey Bernut, Christian Dupont, Nikolay V. Ogryzko, Aymeric Neyret, Jean-Louis Herrmann, R. Andres Floto, Stephen A. Renshaw, Laurent Kremer
CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses
published pages: 1828-1840.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.01.071
Cell Reports 26/7 2019-11-08

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CFZEBRA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CFZEBRA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

MEM-ENTO (2020)

Tracing memory formation in a behaving animal: analysis of learning-induced morpho-functional plasticity along the bee’s olfactory system

Read More