Opendata, web and dolomites


Nichoid: nanoengineered three-dimensional substrate for stem cell expansion

Total Cost €


EC-Contrib. €






 NICHOIDS project word cloud

Explore the words cloud of the NICHOIDS project. It provides you a very rough idea of what is the project "NICHOIDS" about.

cell    nichoids    polymerized    vitro    plastic    market    surface    nichoid    commercial    additives    autoimmune    animal    resin    surgery    organ    expansion    dangerous    culture    mscs    fabrication    extended    guarantee    polymerization    orthopaedic    manufacturing    feeder    repeatable    cells    invention    ipr    therapeutic    safe    reduce    valorising    licensing    few    immune    medicine    implies    injected    scaling    least    poc    speed    explore    safety    regenerative    drastically    squared    stem    sufficient    hours    consolidator    submitted    move    obtaining    substrate    agents    italian    patient    therapy    pct    reconstructive    laboratory    feasibility    2pp    avoiding    mesenchymal    ground    covered    mainly    biocompatible    photon    clinical    suitable    perform    extensive    context    laser    patent    disease    pi    treatment    individual    sources    frontier    manipulation    suppressive    identification    economic    hampering    strategy    cog    setting    effect    cm    actionable    september    cover    transplantation    2015    grant    breaking    degenerative    time    plan    erc    maturity    possibility    nano   

Project "NICHOIDS" data sheet

The following table provides information about the project.


Organization address
city: MILANO
postcode: 20133

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 110˙000.00


 Project objective

'Mesenchymal stem cells (MSCs) raise a great interest for regenerative medicine for many clinical applications such as orthopaedic, plastic and reconstructive surgery, within autoimmune or degenerative disease treatment and as immune-suppressive agents in organ transplantation. In stem cell therapy, cells are injected in the patient after an extensive in vitro manipulation aimed at obtaining a sufficient cell number able to guarantee the therapeutic effect. Currently, stem cell 'manufacturing' implies the use of “feeder” cells and additives from animal sources, hampering the clinical use mainly for safety reasons. In the context of an ERC Consolidator grant (ERC-CoG) that I currently lead, I introduced a novel ground-breaking concept for an easy to use, repeatable, cost-effective, and safe substrate for stem cell expansion, called the “nichoid” substrate, capable of avoiding feeder cells and dangerous additives. The substrate is polymerized with a laser in a biocompatible resin using a frontier nano-fabrication technology called “two-photon laser polymerization” (2PP). To explore the possibility of an economic exploitation of this invention covered by an Italian Patent submitted in September 2015 and already extended as PCT, the goal of this PoC is to perform a technical and commercial feasibility to move the method developed in the PI’s laboratory during the ERC grant to the market. In particular, I plan to speed up the maturity level of the technology further developing the production process of individual nichoids (fabrication up-scaling by at least a factor of 10, allowing to cover a culture surface of 5 squared cm in five hours), setting of an actionable IPR strategy (including a market assessment), identification of the suitable exploitation strategy for valorising the patent/know how (licensing). The nichoid could drastically reduce down to few years the time to market of stem cell products that is currently 20 years.'


year authors and title journal last update
List of publications.
2019 Tommaso Zandrini, Oumin Shan, Valentina Parodi, Giulio Cerullo, Manuela T. Raimondi, Roberto Osellame
Multi-foci laser microfabrication of 3D polymeric scaffolds for stem cell expansion in regenerative medicine
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-48080-w
Scientific Reports 9/1 2019-08-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NICHOIDS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NICHOIDS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  


The Mass Politics of Disintegration

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More