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NanoMOFdeli SIGNED

Design of NanoMOFs Capsules for Drug Delivery and Bioimaging.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoMOFdeli" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://aam.ceb.cam.ac.uk/
 Total cost 1˙903˙685 €
 EC max contribution 1˙903˙685 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙903˙685.00

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 Project objective

Cancer is a major health problem worldwide, being the most common cause of death after cardiovascular diseases. The major goal of new anticancer therapies is to specifically kill tumour cells while leaving healthy cells unharmed. A main challenge to achieve this aim is the development of better drugs, including novel treatments based on the use of siRNAs. These macromolecules are potentially the most powerful anti-cancer drugs that exist, but still there is no efficient way of getting them delivered specifically to the tumour. Indeed, lifetime of such molecules is generally too short and therefore need to be protected in a carrier until they are delivered into tumour target cells.

This project focuses in the development of nanocarriers based on metal-organic frameworks (MOFs), one of the most exciting developments in recent porous materials science. The study of the mechanisms that control drug delivery is of critical importance to nanomedicine applications, where nanotechnology has the potential to revolutionise cancer therapy. Given the challenging nature of the drug delivery problem for cancer therapy, this project builds on 4 interrelated main concepts: i) the design of bio-compatible MOFs for drug delivery applications; ii) the post-synthesis engineering of MOFs to enhance stability, controlled drug release, and targeting; iii) the identification of optimal textural properties (i.e. pore size distribution, surface area, pore volume) and surface chemistry of MOFs for siRNA delivery using experiments and molecular simulation techniques; iv) the assessment of their performance in vitro and in vivo, giving a translational dimension to the proposed research. The novelty of this work lies therefore in the synergistic combination of tools from different areas and disciplines (chemistry, biochemical engineering and medicine) to produce advances that are of both fundamental scientific interest and of bioengineering relevance in nanomedicine applications.

 Publications

year authors and title journal last update
List of publications.
2018 Peyman Z. Moghadam, Timur Islamoglu, Subhadip Goswami, Jason Exley, Marcus Fantham, Clemens F. Kaminski, Randall Q. Snurr, Omar K. Farha, David Fairen-Jimenez
Computer-aided discovery of a metal–organic framework with superior oxygen uptake
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03892-8
Nature Communications 9/1 2020-01-23
2017 Claudia Orellana-Tavra, Salame Haddad, Ross J. Marshall, Isabel Abánades Lázaro, Gerard Boix, Inhar Imaz, Daniel Maspoch, Ross S. Forgan, David Fairen-Jimenez
Tuning the Endocytosis Mechanism of Zr-Based Metal–Organic Frameworks through Linker Functionalization
published pages: 35516-35525, ISSN: 1944-8244, DOI: 10.1021/acsami.7b07342
ACS Applied Materials & Interfaces 9/41 2020-01-23
2019 Johannes W. M. Osterrieth, Demelza Wright, Hyunho Noh, Chung-Wei Kung, Diana Vulpe, Aurelia Li, Ji Eun Park, Richard P. Van Duyne, Peyman Z. Moghadam, Jeremy J. Baumberg, Omar K. Farha, David Fairen-Jimenez
Core–Shell Gold Nanorod@Zirconium-Based Metal–Organic Framework Composites as in Situ Size-Selective Raman Probes
published pages: 3893-3900, ISSN: 0002-7863, DOI: 10.1021/jacs.8b11300
Journal of the American Chemical Society 141/9 2020-01-23
2018 Tian Tian, Zhixin Zeng, Diana Vulpe, Mirian E. Casco, Giorgio Divitini, Paul A. Midgley, Joaquin Silvestre-Albero, Jin-Chong Tan, Peyman Z. Moghadam, David Fairen-Jimenez
A sol–gel monolithic metal–organic framework with enhanced methane uptake
published pages: 174-179, ISSN: 1476-1122, DOI: 10.1038/NMAT5050
Nature Materials 17/2 2020-01-23
2018 Ross J. Marshall, Ciaran T. Lennon, Andi Tao, Hans M. Senn, Claire Wilson, David Fairen-Jimenez, Ross S. Forgan
Controlling interpenetration through linker conformation in the modulated synthesis of Sc metal–organic frameworks
published pages: 1181-1187, ISSN: 2050-7488, DOI: 10.1039/C7TA09699B
Journal of Materials Chemistry A 6/3 2020-01-23
2018 Joshua P. Mehta, Benjamin R. Knappett, Giorgio Divitini, Emilie Ringe, Paul A. Midgley, David Fairen-Jimenez, Andrew E. H. Wheatley
Advances in the Synthesis and Long-Term Protection of Zero-Valent Iron Nanoparticles
published pages: 1800120, ISSN: 0934-0866, DOI: 10.1002/ppsc.201800120
Particle & Particle Systems Characterization 35/8 2020-01-23

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