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META-DORM SIGNED

Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "META-DORM" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://stefaanverbruggen.com/
 Total cost 183˙792 €
 EC max contribution 183˙792 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-06-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙792.00
2    TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US (NEW YORK) partner 0.00

Map

 Project objective

While cancer survival rates have improved significantly in recent years, survival decreases dramatically after tumour metastasis. One of the most common sites for metastatic tumours to develop is bone. Intriguingly, evidence suggests that once they have invaded the bone marrow, individual metastatic cancer cells can persist for years in a quiescent or “dormant” state, and are resistant to both radiation and chemotherapy treatment. These dormant cells can reside for months or years while the cancer is in remission, and then “reactivate” without warning to form new, usually fatal, skeletal lesions. Tumour cells achieve this by “hijacking” the normal bone remodelling cycle, a homeostatic balance between bone formation and resorption, to form a metastatic niche within the marrow. However, the signalling mechanisms that cause metastasis and dormancy, particularly in such a mechanically active environment, are poorly understood. Therefore, the goal of this project is to investigate the chemical and physical interactions between bone and cancer cells, both during dormancy and mechanical stimulation, to provide new insight into bone metastatic lesions and explore novel therapeutic targets to prevent cancer metastasis. This will be achieved by culturing specific bone and cancer cell types together for the first time to observe changes in their signalling and behaviour. Dormancy will also be induced, to observe its effect on changes in signalling. Mechanical stimulation will be applied to investigate whether the complex mechanical environment of the bone marrow plays a role in cancer metastasis. Finally, a specific cellular mechanosensor, the primary cilium, which has been implicated in the development of cancer and is known to be involved in bone formation, will be investigated. This will shed new light on its chemosensing and mechanobiological roles in cancer metastasis, as well as explore its potential as a novel target for cancer treatment and prevention.

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The information about "META-DORM" are provided by the European Opendata Portal: CORDIS opendata.

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