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NeMatrix

Nematode-based screening technology for next-generation drug discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeMatrix project word cloud

Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.

culture    separate    rely    platform    named    species    observation    fill    definitely    model    manual    automated    feed    paving    protocols    standards    examples    mammals    worms    employ    alternative    organism    creation    company    close    throughput    population    microfluidic    actual    envisioned    gently    device    starting    maintenance    big    refinement    phenotypes    drug    proposes    techniques    elegans    concentrations    data    tests    completely    operations    monitor    distribute    generation    nematodes    industries    food    framework    lacking    size    flies    popular    time    gap    store    expose    roundworms    animal    reproducibility    models    organisms    industrial    worm    prototype    interesting    suitable    microcompartments    rate    startup    handling    caenorhabditis    replacing    desired    hinders    concentration    discovery    biomedical    context    microscopic    replacement    multiple    technological    technologies    clinical    pharmaceutical    screening    proving    suspension    roundworm    first    nematrix   

Project "NeMatrix" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.

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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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