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NeMatrix

Nematode-based screening technology for next-generation drug discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeMatrix project word cloud

Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.

feed    desired    actual    roundworm    creation    proving    technological    nematrix    mammals    suitable    replacing    drug    gently    population    rely    data    industrial    device    screening    prototype    operations    biomedical    size    context    time    model    caenorhabditis    store    generation    multiple    platform    techniques    roundworms    replacement    big    fill    automated    tests    worm    concentrations    definitely    named    clinical    alternative    microscopic    separate    animal    expose    paving    concentration    starting    worms    organism    completely    phenotypes    nematodes    handling    examples    employ    rate    microfluidic    technologies    first    throughput    manual    pharmaceutical    monitor    gap    protocols    startup    species    framework    industries    culture    maintenance    suspension    lacking    distribute    discovery    organisms    hinders    models    refinement    company    proposes    elegans    envisioned    observation    close    food    microcompartments    flies    popular    interesting    standards    reproducibility   

Project "NeMatrix" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.

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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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