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NeMatrix

Nematode-based screening technology for next-generation drug discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeMatrix project word cloud

Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.

paving    elegans    lacking    framework    first    hinders    named    pharmaceutical    context    concentrations    fill    protocols    replacing    examples    time    worm    manual    model    separate    population    popular    organisms    techniques    phenotypes    suspension    rely    discovery    operations    completely    organism    microscopic    tests    data    food    refinement    species    gently    employ    size    envisioned    models    rate    culture    maintenance    desired    expose    microcompartments    roundworms    animal    worms    alternative    industries    biomedical    big    device    creation    automated    industrial    multiple    suitable    feed    generation    screening    drug    gap    distribute    definitely    startup    monitor    flies    handling    prototype    company    concentration    starting    standards    throughput    nematodes    technological    clinical    mammals    nematrix    caenorhabditis    reproducibility    proving    close    microfluidic    roundworm    replacement    technologies    interesting    store    observation    actual    proposes    platform   

Project "NeMatrix" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.

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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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