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ABA-GrowthBalance SIGNED

Growth balance regulation by SnRK1 under ABA-stress conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ABA-GrowthBalance project word cloud

Explore the words cloud of the ABA-GrowthBalance project. It provides you a very rough idea of what is the project "ABA-GrowthBalance" about.

metabolism    regulation    player    offs    snrk    stresses    mechanisms    snrk1    regulators    deficient    trade    expression    rapamycin    vast    genomics    kinase    tackle    combination    crop    trigger    activated    promotes    sensing    protein    tor    partial    physical    mutant    tolerance    functional    expense    suggesting    productivity    unbiased    snrk2    revealed    altogether    relevance    aba    molecular    gene    preliminary    unknown    plants    substrates    assays    axis    largely    scarcity    host    downstream    adaptive    hormone    successful    survival    extreme    salinity    microscopy    temperatures    central    negative    cellular    despite    plant    mechanism    signalling    yield    devastating    interaction    stress    genetics    implicated    kinases    interactors    triggers    improvement    elucidate    connection    water    biochemical    modified    potentially    adverse    employed    repression    environmental    cell    readouts    chemical    regulator    energy    lab    function    activation    modulate   

Project "ABA-GrowthBalance" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 159˙815 €
 EC max contribution 159˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 159˙815.00

Map

 Project objective

In response to adverse environmental conditions, such as water scarcity, extreme temperatures or salinity plants trigger responses that promote stress tolerance and survival at the expense of growth. Despite the negative impact of stress on crop productivity how growth is modified by stress signalling pathways is largely unknown. One major component of the response to the most devastating stresses is ABA, a hormone that triggers cellular and whole-plant adaptive mechanisms via the activation of SnRK2 protein kinases. Another major player is the energy sensing SnRK1 protein kinase, which promotes plant stress tolerance and survival through the vast regulation of metabolism and gene expression. Preliminary results in the host lab have revealed deficient ABA responses in a partial SnRK1 loss-of-function mutant as well as the physical interaction between SnRK1 and the ABA-activated SnRK2 kinases, suggesting a functional connection between these two pathways. Furthermore, SnRK1 and SnRK2 have recently been implicated in the repression of a central growth regulator, the TOR (Target of Rapamycin) protein kinase. The aim of this proposal is to investigate the interaction between these two major stress-related kinases (SnRK1 and SnRK2) and to elucidate the mechanism(s) by which they modulate growth-promoting signalling pathways in response to ABA. To tackle the functional relevance of the SnRK1-SnRK2 connection, a combination of biochemical approaches, genetics, microscopy, cell-based assays and chemical genomics will be used. To identify growth regulators downstream of the SnRK axis, targeted analyses of TOR readouts will be employed in combination with unbiased analyses of SnRK1 interactors and substrates in ABA. Altogether this project will provide novel molecular insight on the trade-offs between stress tolerance and growth/yield that may potentially contribute to more successful crop improvement.

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