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HHMM-Neonates SIGNED

DEVELOPMENT OF HEALTHY HOST-MICROBIAL MUTUALISM IN EARLY LIFE

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HHMM-Neonates project word cloud

Explore the words cloud of the HHMM-Neonates project. It provides you a very rough idea of what is the project "HHMM-Neonates" about.

appreciated    prepares    metabolic    shaping    mammalian    free    profound    dissected    harbour    signatures    extinctions    develops    identity    signalling    microbiota    blooms    clear    significance    inflammatory    independent    disease    enormous    microbial    gnotobiotic    pervasive    resolution    resistance    shapes    influences    immunopathology    epigenetic    protection    host    molecular    dynamics    mechanisms    innate    precisely    reveal    repertoire    life    newborn    strain    vivo    intestine    conversely    earliest    hypothesis    suckling    combinations    group    lymphocyte    marks    offspring    axenic    metabolism    nutrition    critical    earlier    ing    portfolio    metabolomics    fetal    immunity    gestation    germ    shown    transitions    driving    colonisation    starting    phases    humans    background    generally    reversible    interdependence    lactation    infectious    metabolites    later    interactions    determined    exposure    autoimmune    birth    animals    window    maternal    incoming    core    flow    lower    previously   

Project "HHMM-Neonates" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 2˙500˙000.00

Map

 Project objective

Background Humans and other animals harbour enormous microbial consortia, especially in the lower intestine. My group has now shown that effects of the microbiota on host are far earlier and more pervasive than previously appreciated, starting even before birth from exposure to defined maternal microbial metabolites. Concept There is a critical window for development of immunity and metabolism in early life. This shapes infectious resistance, lymphocyte repertoire development and the likelihood of later autoimmune or inflammatory disease. We will determine the molecular mechanisms of how the maternal microbiota prepares the newborn for the critical fetal/suckling/early-independent-nutrition transitions. The core hypothesis is that generally pervasive effects of maternal microbial influences, so-far investigated only for innate immunity and metabolism of germ-free offspring, can be defined in terms of a clear portfolio of maternal microbial molecular signatures and epigenetic marks as the newborn develops with its own microbiota. Approach Interdependence of microbial ⇄ host interactions during gestation and lactation will be dissected using reversible colonisation systems under axenic and precisely controlled gnotobiotic conditions. The flow and identity of maternal microbial metabolites driving development and shaping incoming colonisation shall be determined from high-resolution metabolomics and host strain combinations that reveal in vivo signalling and epigenetic marks. Significance The project will reveal mechanisms of the earliest phases of mammalian adaptation to a microbiota, the epigenetic effects of maternal microbial metabolites and the resulting potential protection from metabolic disease or immunopathology. Conversely, there are profound effects of early life adaptation on the dynamics of microbial colonisation and the potential blooms and extinctions for the incoming microbiota: the project will define the different mechanisms involved.

 Publications

year authors and title journal last update
List of publications.
2019 Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Cheng Yuan, Kai W. Wucherpfennig, Stephan R. Targan, Philip Rosenstiel, Richard A. Flavell, Kathy D. McCoy, Andrew J. Macpherson, Arthur Kaser, Richard S. Blumberg
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
published pages: 993-998, ISSN: 0036-8075, DOI: 10.1126/science.aat7186
Science 363/6430 2019-05-23
2018 Andrew J. Macpherson, Bahtiyar Yilmaz, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg
IgA Function in Relation to the Intestinal Microbiota
published pages: 359-381, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042617-053238
Annual Review of Immunology 36/1 2019-05-23
2018 Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg
Checkpoint for gut microbes after birth
published pages: 436-438, ISSN: 0028-0836, DOI: 10.1038/d41586-018-05861-z
Nature 560/7719 2019-05-23
2018 Yasuhiro Uchimura, Tobias Fuhrer, Hai Li, Melissa A. Lawson, Michael Zimmermann, Bahtiyar Yilmaz, Joel Zindel, Francesca Ronchi, Marcel Sorribas, Siegfried Hapfelmeier, Stephanie C. Ganal-Vonarburg, Mercedes Gomez de Agüero, Kathy D. McCoy, Uwe Sauer, Andrew J. Macpherson
Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response
published pages: 545-559.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.08.004
Immunity 49/3 2019-05-23
2018 Mathilde J.H. Girard-Madoux, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Catherine Mooser, Gabrielle T. Belz, Andrew J. Macpherson, Eric Vivier
The immunological functions of the Appendix: An example of redundancy?
published pages: 31-44, ISSN: 1044-5323, DOI: 10.1016/j.smim.2018.02.005
Seminars in Immunology 36 2019-05-23
2019 Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Reiner Wiest, Jörg Stelling, Andrew J. Macpherson
Microbial network disturbances in relapsing refractory Crohn’s disease
published pages: 323-336, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0308-z
Nature Medicine 25/2 2019-05-27
2018 Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg
IgA—about the unexpected
published pages: 1965-1966, ISSN: 0022-1007, DOI: 10.1084/jem.20181153
The Journal of Experimental Medicine 215/8 2019-05-27
2017 Andrew J. Macpherson, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg
How nutrition and the maternal microbiota shape the neonatal immune system
published pages: 508-517, ISSN: 1474-1733, DOI: 10.1038/nri.2017.58
Nature Reviews Immunology 17/8 2019-05-27
2017 Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria
A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis
published pages: 655-667.e17, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.09.022
Cell 171/3 2019-05-23

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