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HHMM-Neonates SIGNED

DEVELOPMENT OF HEALTHY HOST-MICROBIAL MUTUALISM IN EARLY LIFE

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HHMM-Neonates project word cloud

Explore the words cloud of the HHMM-Neonates project. It provides you a very rough idea of what is the project "HHMM-Neonates" about.

gnotobiotic    influences    epigenetic    phases    significance    driving    earlier    enormous    shaping    newborn    shapes    signatures    interactions    disease    metabolites    hypothesis    intestine    birth    harbour    blooms    colonisation    determined    window    offspring    microbial    host    reversible    molecular    inflammatory    incoming    mammalian    lymphocyte    lower    conversely    suckling    maternal    infectious    prepares    metabolism    pervasive    autoimmune    free    later    axenic    immunopathology    generally    gestation    dissected    shown    group    interdependence    profound    repertoire    starting    clear    marks    previously    critical    combinations    precisely    metabolic    appreciated    flow    fetal    earliest    humans    portfolio    exposure    independent    germ    lactation    protection    reveal    background    identity    resolution    resistance    develops    mechanisms    life    metabolomics    extinctions    microbiota    animals    ing    core    innate    transitions    nutrition    vivo    immunity    dynamics    strain    signalling   

Project "HHMM-Neonates" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 2˙500˙000.00

Map

 Project objective

Background Humans and other animals harbour enormous microbial consortia, especially in the lower intestine. My group has now shown that effects of the microbiota on host are far earlier and more pervasive than previously appreciated, starting even before birth from exposure to defined maternal microbial metabolites. Concept There is a critical window for development of immunity and metabolism in early life. This shapes infectious resistance, lymphocyte repertoire development and the likelihood of later autoimmune or inflammatory disease. We will determine the molecular mechanisms of how the maternal microbiota prepares the newborn for the critical fetal/suckling/early-independent-nutrition transitions. The core hypothesis is that generally pervasive effects of maternal microbial influences, so-far investigated only for innate immunity and metabolism of germ-free offspring, can be defined in terms of a clear portfolio of maternal microbial molecular signatures and epigenetic marks as the newborn develops with its own microbiota. Approach Interdependence of microbial ⇄ host interactions during gestation and lactation will be dissected using reversible colonisation systems under axenic and precisely controlled gnotobiotic conditions. The flow and identity of maternal microbial metabolites driving development and shaping incoming colonisation shall be determined from high-resolution metabolomics and host strain combinations that reveal in vivo signalling and epigenetic marks. Significance The project will reveal mechanisms of the earliest phases of mammalian adaptation to a microbiota, the epigenetic effects of maternal microbial metabolites and the resulting potential protection from metabolic disease or immunopathology. Conversely, there are profound effects of early life adaptation on the dynamics of microbial colonisation and the potential blooms and extinctions for the incoming microbiota: the project will define the different mechanisms involved.

 Publications

year authors and title journal last update
List of publications.
2019 Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Cheng Yuan, Kai W. Wucherpfennig, Stephan R. Targan, Philip Rosenstiel, Richard A. Flavell, Kathy D. McCoy, Andrew J. Macpherson, Arthur Kaser, Richard S. Blumberg
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
published pages: 993-998, ISSN: 0036-8075, DOI: 10.1126/science.aat7186
Science 363/6430 2019-05-23
2018 Andrew J. Macpherson, Bahtiyar Yilmaz, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg
IgA Function in Relation to the Intestinal Microbiota
published pages: 359-381, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042617-053238
Annual Review of Immunology 36/1 2019-05-23
2018 Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg
Checkpoint for gut microbes after birth
published pages: 436-438, ISSN: 0028-0836, DOI: 10.1038/d41586-018-05861-z
Nature 560/7719 2019-05-23
2018 Yasuhiro Uchimura, Tobias Fuhrer, Hai Li, Melissa A. Lawson, Michael Zimmermann, Bahtiyar Yilmaz, Joel Zindel, Francesca Ronchi, Marcel Sorribas, Siegfried Hapfelmeier, Stephanie C. Ganal-Vonarburg, Mercedes Gomez de Agüero, Kathy D. McCoy, Uwe Sauer, Andrew J. Macpherson
Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response
published pages: 545-559.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.08.004
Immunity 49/3 2019-05-23
2018 Mathilde J.H. Girard-Madoux, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Catherine Mooser, Gabrielle T. Belz, Andrew J. Macpherson, Eric Vivier
The immunological functions of the Appendix: An example of redundancy?
published pages: 31-44, ISSN: 1044-5323, DOI: 10.1016/j.smim.2018.02.005
Seminars in Immunology 36 2019-05-23
2019 Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Reiner Wiest, Jörg Stelling, Andrew J. Macpherson
Microbial network disturbances in relapsing refractory Crohn’s disease
published pages: 323-336, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0308-z
Nature Medicine 25/2 2019-05-27
2018 Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg
IgA—about the unexpected
published pages: 1965-1966, ISSN: 0022-1007, DOI: 10.1084/jem.20181153
The Journal of Experimental Medicine 215/8 2019-05-27
2017 Andrew J. Macpherson, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg
How nutrition and the maternal microbiota shape the neonatal immune system
published pages: 508-517, ISSN: 1474-1733, DOI: 10.1038/nri.2017.58
Nature Reviews Immunology 17/8 2019-05-27
2017 Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria
A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis
published pages: 655-667.e17, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.09.022
Cell 171/3 2019-05-23

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