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CHEMREACTIONSCAN SIGNED

Scanner for novel chemical reactions

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "CHEMREACTIONSCAN" data sheet

The following table provides information about the project.

Coordinator
KARLSRUHER INSTITUT FUER TECHNOLOGIE 

Organization address
address: KAISERSTRASSE 12
city: KARLSRUHE
postcode: 76131
website: www.kit.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙875 €
 EC max contribution 149˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) coordinator 149˙875.00

Map

 Project objective

Funded by the ERC-Starting Grant COMBIPATTERNING, we have developed a novel nanolayer-based synthesis based on patterning different materials with laser radiation in form of a pan-cake spots in array format. Our synthesis robot can do it for many different materials, for >40.000 spots per glass slide, in exactly defined stoichiometries, and for <200 € costs. The robot uses short laser pulses to transfer <1ng “punched-out” material per spot from a donor foil to a synthesis slide. Then, the reactants embedded in the nano thin polymer pan-cake spots can mix with each other and thus undergo chemical reactions by heating the synthesis slide. Due to the large progress in MALDI imaging and the fluorescent scanners, the results of the reactions can be analyzed in the same array format. The masses found by MALDI imaging in some spots might help us to identify unknown chemical reactions. We believe that the nanolayer-based synthesis developed by us might be a basis for future chemistry stations linking scientists and accelerating their studies to screen for novel chemical reactions in a high throughput manner. Instead of studying the interaction between reactants in a single test glass, the chemists will just spin-coat their educts on microscope slides and supply them together with a file for desired reactant combinations to the server - chemical reaction scanner. Therefore, we want to verify the innovation potential of the nanolayer-based synthesis that should find a market where a novel synthesis strategy on combining novel building blocks should be developed, especially, in the field of novel bioactive chemicals and fluorophores.

 Publications

year authors and title journal last update
List of publications.
2019 Andrea Palermo, Richard Thelen, Laura Weber, Tobias Foertsch, Simone Rentschler, Verena Hackert, Julia Syurik, Alexander Nesterov-Mueller
Vertical Scanning Interferometry for Label-Free Detection of Peptide-Antibody Interactions
published pages: 7, ISSN: 2571-5135, DOI: 10.3390/ht8020007
High-Throughput 8/2 2019-06-06
2019 Tobias C. Foertsch, Alex T. Davis, Roman Popov, Clemens von Bojničić-Kninski, Felix E. Held, Svetlana B. Tsogoeva, Felix F. Loeffler, Alexander Nesterov-Mueller
Spatial Modes of Laser-Induced Mass Transfer in Micro-Gaps
published pages: 1303, ISSN: 2076-3417, DOI: 10.3390/app9071303
Applied Sciences 9/7 2019-06-06
2019 Daniela. S. Mattes, Bettina Streit, Dhaka R. Bhandari, Juliane Greifenstein, Tobias C. Foertsch, Stephan W. Münch, Barbara Ridder, Clemens v. Bojničić‐Kninski, Alexander Nesterov‐Mueller, Bernhard Spengler, Ute Schepers, Stefan Bräse, Felix F. Loeffler, Frank Breitling
Combinatorial Synthesis of Peptoid Arrays via Laser‐Based Stacking of Multiple Polymer Nanolayers
published pages: 1800533, ISSN: 1022-1336, DOI: 10.1002/marc.201800533
Macromolecular Rapid Communications 40/6 2019-06-06

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