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PeptIn

employing protein aggregation as an antibacterial design strategy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PeptIn project word cloud

Explore the words cloud of the PeptIn project. It provides you a very rough idea of what is the project "PeptIn" about.

aggregating    sepsis    investors    cell    leads    therapeutic    segments    events    therapeutics    fail    novelty    fight    precise    tap    industry    viability    aggregation    designed    presented    bodies    pace    dawn    mango    cured    vitro    series    strains    healthcare    aureus    resistance    hypothesis    era    generate    coli    antibiotic    interactions    prone    pharmaceutical    peptides    outline    bacteria    meet    elucidated    cells    diseases    consolidate    post    raised    search    experiments    protein    identification    chain    exploited    cytosol    urgent    bactericidal    space    pathogenic    resistant    enter    mined    screening    experts    accumulate    strategies    antimicrobial    toxic    encoding    whom    proteins    bacterial    erc    drug    global    sequence    elicit    proteomes    polypeptides    display    sequences    chemical    fear    globally    data    hits    aggregates    mice    gram    infectious    questions    initiating    unbiased    apparent    examined    threatening    mammalian    death    unexplored    inclusion   

Project "PeptIn" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 150˙000.00

Map

 Project objective

Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence segments of bacterial proteins can display antimicrobial activity by initiating aggregation in bacteria but not in mammalian cells. Unbiased in vitro screening of aggregating peptides lead to the identification of several hits that are strongly bactericidal against drug resistant gram S aureus strains, and others against pathogenic gram- E coli strains. The peptides cured mice from bacterial sepsis without apparent toxic side effects. The peptides enter and accumulate in the bacterial cytosol where they cause aggregation of bacterial polypeptides and the formation of inclusion bodies. Although the precise chain of events that leads to cell death remains to be elucidated, the ability to tap into aggregation-prone sequences of bacterial proteomes to elicit antimicrobial activity represents a rich and unexplored chemical space to be mined in search of novel therapeutic strategies to fight infectious diseases that are increasingly threatening global healthcare. However, given the novelty of this concept, the viability of aggregating peptides as antimicrobial therapeutics needs to be further advanced in order to consolidate the already significant interest from the pharmaceutical industry. In the current proposal we outline a series of experiments designed to address some of the key questions that were raised by potential investors and experts from the pharmaceutical sector to whom we presented the current data package.

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The information about "PEPTIN" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-16 22:58:52) correctly updated