Opendata, web and dolomites

PeptIn

employing protein aggregation as an antibacterial design strategy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PeptIn project word cloud

Explore the words cloud of the PeptIn project. It provides you a very rough idea of what is the project "PeptIn" about.

infectious    exploited    tap    therapeutics    aggregating    resistance    erc    aureus    gram    viability    examined    sequence    chemical    consolidate    sequences    healthcare    series    mammalian    outline    antibiotic    enter    data    bacterial    mango    interactions    initiating    dawn    coli    experiments    mice    questions    resistant    therapeutic    precise    global    era    space    fail    chain    identification    peptides    globally    whom    urgent    leads    bacteria    proteins    vitro    presented    post    toxic    pathogenic    screening    sepsis    novelty    experts    cell    cells    meet    investors    designed    prone    pace    cytosol    search    diseases    events    protein    proteomes    strains    elucidated    mined    accumulate    antimicrobial    pharmaceutical    aggregates    polypeptides    inclusion    death    unexplored    encoding    segments    raised    threatening    industry    bodies    hits    elicit    display    fight    apparent    drug    generate    aggregation    bactericidal    unbiased    fear    hypothesis    strategies    cured   

Project "PeptIn" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 150˙000.00

Map

 Project objective

Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence segments of bacterial proteins can display antimicrobial activity by initiating aggregation in bacteria but not in mammalian cells. Unbiased in vitro screening of aggregating peptides lead to the identification of several hits that are strongly bactericidal against drug resistant gram S aureus strains, and others against pathogenic gram- E coli strains. The peptides cured mice from bacterial sepsis without apparent toxic side effects. The peptides enter and accumulate in the bacterial cytosol where they cause aggregation of bacterial polypeptides and the formation of inclusion bodies. Although the precise chain of events that leads to cell death remains to be elucidated, the ability to tap into aggregation-prone sequences of bacterial proteomes to elicit antimicrobial activity represents a rich and unexplored chemical space to be mined in search of novel therapeutic strategies to fight infectious diseases that are increasingly threatening global healthcare. However, given the novelty of this concept, the viability of aggregating peptides as antimicrobial therapeutics needs to be further advanced in order to consolidate the already significant interest from the pharmaceutical industry. In the current proposal we outline a series of experiments designed to address some of the key questions that were raised by potential investors and experts from the pharmaceutical sector to whom we presented the current data package.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PEPTIN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PEPTIN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOCELFATE (2019)

Evolution of cell fate specification modes in spiral cleavage

Read More  

SLAMseq (2019)

SLAMseq: Temporal resolution in gene expression profiling across multiple platforms

Read More  

SmartForests (2020)

Smart Forests: Transforming Environments into Social-Political Technologies

Read More