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PeptIn

employing protein aggregation as an antibacterial design strategy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PeptIn project word cloud

Explore the words cloud of the PeptIn project. It provides you a very rough idea of what is the project "PeptIn" about.

vitro    exploited    protein    globally    global    novelty    viability    cytosol    events    strains    therapeutics    infectious    drug    fight    raised    questions    pathogenic    cured    industry    cell    era    erc    designed    tap    experiments    diseases    unbiased    bactericidal    unexplored    dawn    segments    antimicrobial    elucidated    initiating    apparent    inclusion    interactions    aggregates    hypothesis    encoding    toxic    resistance    sequences    chemical    coli    space    sequence    healthcare    search    enter    precise    investors    leads    cells    generate    threatening    sepsis    fail    accumulate    identification    whom    mice    hits    mined    presented    series    therapeutic    consolidate    pace    urgent    prone    gram    mammalian    data    proteins    chain    display    peptides    mango    proteomes    post    polypeptides    antibiotic    bacterial    meet    examined    screening    bodies    resistant    outline    experts    aggregation    bacteria    death    aureus    elicit    strategies    pharmaceutical    fear    aggregating   

Project "PeptIn" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 150˙000.00

Map

 Project objective

Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence segments of bacterial proteins can display antimicrobial activity by initiating aggregation in bacteria but not in mammalian cells. Unbiased in vitro screening of aggregating peptides lead to the identification of several hits that are strongly bactericidal against drug resistant gram S aureus strains, and others against pathogenic gram- E coli strains. The peptides cured mice from bacterial sepsis without apparent toxic side effects. The peptides enter and accumulate in the bacterial cytosol where they cause aggregation of bacterial polypeptides and the formation of inclusion bodies. Although the precise chain of events that leads to cell death remains to be elucidated, the ability to tap into aggregation-prone sequences of bacterial proteomes to elicit antimicrobial activity represents a rich and unexplored chemical space to be mined in search of novel therapeutic strategies to fight infectious diseases that are increasingly threatening global healthcare. However, given the novelty of this concept, the viability of aggregating peptides as antimicrobial therapeutics needs to be further advanced in order to consolidate the already significant interest from the pharmaceutical industry. In the current proposal we outline a series of experiments designed to address some of the key questions that were raised by potential investors and experts from the pharmaceutical sector to whom we presented the current data package.

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The information about "PEPTIN" are provided by the European Opendata Portal: CORDIS opendata.

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