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PeptIn

employing protein aggregation as an antibacterial design strategy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 PeptIn project word cloud

Explore the words cloud of the PeptIn project. It provides you a very rough idea of what is the project "PeptIn" about.

peptides    protein    drug    whom    outline    apparent    pharmaceutical    globally    prone    antibiotic    fight    dawn    polypeptides    presented    space    viability    fear    urgent    raised    threatening    investors    healthcare    pace    coli    antimicrobial    hits    hypothesis    sequence    pathogenic    cytosol    accumulate    cured    bodies    death    data    experiments    mice    bactericidal    aureus    global    sequences    series    screening    cells    display    proteins    sepsis    identification    erc    examined    chemical    unbiased    designed    questions    proteomes    resistant    aggregates    search    toxic    generate    leads    meet    strategies    bacteria    events    chain    elucidated    interactions    gram    strains    exploited    bacterial    tap    encoding    elicit    mammalian    initiating    enter    industry    mined    diseases    vitro    fail    infectious    consolidate    mango    resistance    unexplored    therapeutics    therapeutic    segments    cell    experts    inclusion    aggregation    post    aggregating    era    precise    novelty   

Project "PeptIn" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 150˙000.00

Map

 Project objective

Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence segments of bacterial proteins can display antimicrobial activity by initiating aggregation in bacteria but not in mammalian cells. Unbiased in vitro screening of aggregating peptides lead to the identification of several hits that are strongly bactericidal against drug resistant gram S aureus strains, and others against pathogenic gram- E coli strains. The peptides cured mice from bacterial sepsis without apparent toxic side effects. The peptides enter and accumulate in the bacterial cytosol where they cause aggregation of bacterial polypeptides and the formation of inclusion bodies. Although the precise chain of events that leads to cell death remains to be elucidated, the ability to tap into aggregation-prone sequences of bacterial proteomes to elicit antimicrobial activity represents a rich and unexplored chemical space to be mined in search of novel therapeutic strategies to fight infectious diseases that are increasingly threatening global healthcare. However, given the novelty of this concept, the viability of aggregating peptides as antimicrobial therapeutics needs to be further advanced in order to consolidate the already significant interest from the pharmaceutical industry. In the current proposal we outline a series of experiments designed to address some of the key questions that were raised by potential investors and experts from the pharmaceutical sector to whom we presented the current data package.

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The information about "PEPTIN" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-10-01 3:07:46) correctly updated