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Precision4Life

Precision mass spectrometry to leverage applications in life and environmental sciences

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Precision4Life" data sheet

The following table provides information about the project.

Coordinator
SPECTROSWISS SARL 

Organization address
address: EPFL INNOVATION PARK BUILDING I
city: LAUSANNE
postcode: 1015
website: www.spectroswiss.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SPECTROSWISS SARL CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

The unbeatable performance leaders in molecular analysis of biological and environmental samples are the Fourier transform mass spectrometers (FTMS): Orbitrap FTMS and ion cyclotron resonance (FT-ICR MS). However, even FTMS approaches suffer from performance limitations when facing the molecular complexity of samples in modern applications. The primary reasons for these limitations are the space charge effects – strong Coulombic interactions of many ions oscillating in the trapping devices. Applications suffering from space charge affects include those with (i) significant fluctuation of incoming ion currents; (ii) close spacing of molecular mass/charge ratios to be resolved; and (iii) high spectral dynamic range of ion intensities. To address these performance challenges and as a result of the completed ERC Starting Grant, we propose to increase precision of mass measurements in FT-ICR MS by using the direct cyclotron frequency measurements instead of the space charge-sensitive reduced cyclotron frequency measurements employed currently. We have confirmed the principal feasibility of FT-ICR MS at the cyclotron frequency on both types of commercial FT-ICR MS instruments on the lab level. The aim of our PoC grant application is to realize the benefits of FT-ICR MS at the cyclotron frequency by developing and seamlessly integrating the laboratory-level innovation into commercial instruments at an industry-grade level to leverage life and environmental sciences applications. The action plan includes: (i) enabling integration of prototype ICR mass analyzers into commercial FT-ICR MS instruments via feasibility studies and pilot projects; (ii) analyzing competitive advantages of the project’s outcomes over existing products and workflows, with a focus on frequency (mass) precision increase; (iii) clarifying IPR position, strategy; and (iv) performing market analysis.

 Publications

year authors and title journal last update
List of publications.
2018 Konstantin O. Nagornov, Anton N. Kozhinov, Yury O. Tsybin
Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency
published pages: 63-77, ISSN: 1044-0305, DOI: 10.1007/s13361-017-1821-x
Journal of The American Society for Mass Spectrometry 29/1 2019-05-28
2019 Sunitha Narasimha, Konstantin O. Nagornov, Laure Menin, Antonio Mucciolo, Astrid Rohwedder, Bruno M. Humbel, Martin Stevens, Andreas S. Thum, Yury O. Tsybin, Roshan K. Vijendravarma
Drosophila melanogaster cloak their eggs with pheromones, which prevents cannibalism
published pages: e2006012, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.2006012
PLOS Biology 17/1 2019-05-28
2018 Joshua A. Driver, Konstantin O. Nagornov, Anton N. Kozhinov, Yury O. Tsybin, Andriy Kharchenko, I. Jonathan Amster
Multiparticle Simulations of Quadrupolar Ion Detection in an Ion Cyclotron Resonance Cell with Four Narrow Aperture Detection Electrodes
published pages: 51-62, ISSN: 1044-0305, DOI: 10.1007/s13361-017-1817-6
Journal of The American Society for Mass Spectrometry 29/1 2019-05-28

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