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Precision4Life

Precision mass spectrometry to leverage applications in life and environmental sciences

Total Cost €

EC-Contrib. €

Partnership

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Precision4Life project word cloud

Explore the words cloud of the Precision4Life project. It provides you a very rough idea of what is the project "Precision4Life" about.

resolved environmental transform incoming spacing clarifying feasibility close resonance performing lab molecular fluctuation outcomes benefits industry seamlessly types confirmed laboratory commercial suffer competitive complexity ion samples workflows poc ms instead icr sensitive performance mass analyzing strategy intensities market integration spectrometers spectral position pilot starting leaders currents leverage ftms modern grant unbeatable ft trapping grade dynamic biological prototype erc principal ions primary frequency precision life ratios analyzers integrating cyclotron fourier suffering instruments ipr direct innovation oscillating employed limitations charge plan realize orbitrap interactions coulombic sciences advantages space action

Project "Precision4Life" data sheet

The following table provides information about the project.

Coordinator	SPECTROSWISS SARL Organization address address: EPFL INNOVATION PARK BUILDING I city: LAUSANNE postcode: 1015 website: www.spectroswiss.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SPECTROSWISS SARL SPECTROSWISS SARL Organization address address: EPFL INNOVATION PARK BUILDING I city: LAUSANNE postcode: 1015 website: www.spectroswiss.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	coordinator	150˙000.00

Map

Project objective

The unbeatable performance leaders in molecular analysis of biological and environmental samples are the Fourier transform mass spectrometers (FTMS): Orbitrap FTMS and ion cyclotron resonance (FT-ICR MS). However, even FTMS approaches suffer from performance limitations when facing the molecular complexity of samples in modern applications. The primary reasons for these limitations are the space charge effects – strong Coulombic interactions of many ions oscillating in the trapping devices. Applications suffering from space charge affects include those with (i) significant fluctuation of incoming ion currents; (ii) close spacing of molecular mass/charge ratios to be resolved; and (iii) high spectral dynamic range of ion intensities. To address these performance challenges and as a result of the completed ERC Starting Grant, we propose to increase precision of mass measurements in FT-ICR MS by using the direct cyclotron frequency measurements instead of the space charge-sensitive reduced cyclotron frequency measurements employed currently. We have confirmed the principal feasibility of FT-ICR MS at the cyclotron frequency on both types of commercial FT-ICR MS instruments on the lab level. The aim of our PoC grant application is to realize the benefits of FT-ICR MS at the cyclotron frequency by developing and seamlessly integrating the laboratory-level innovation into commercial instruments at an industry-grade level to leverage life and environmental sciences applications. The action plan includes: (i) enabling integration of prototype ICR mass analyzers into commercial FT-ICR MS instruments via feasibility studies and pilot projects; (ii) analyzing competitive advantages of the project’s outcomes over existing products and workflows, with a focus on frequency (mass) precision increase; (iii) clarifying IPR position, strategy; and (iv) performing market analysis.

Publications

List of publications.
year	authors and title	journal	last update
2018	Konstantin O. Nagornov, Anton N. Kozhinov, Yury O. Tsybin Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency published pages: 63-77, ISSN: 1044-0305, DOI: 10.1007/s13361-017-1821-x	Journal of The American Society for Mass Spectrometry 29/1	2019-05-28
2019	Sunitha Narasimha, Konstantin O. Nagornov, Laure Menin, Antonio Mucciolo, Astrid Rohwedder, Bruno M. Humbel, Martin Stevens, Andreas S. Thum, Yury O. Tsybin, Roshan K. Vijendravarma Drosophila melanogaster cloak their eggs with pheromones, which prevents cannibalism published pages: e2006012, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.2006012	PLOS Biology 17/1	2019-05-28
2018	Joshua A. Driver, Konstantin O. Nagornov, Anton N. Kozhinov, Yury O. Tsybin, Andriy Kharchenko, I. Jonathan Amster Multiparticle Simulations of Quadrupolar Ion Detection in an Ion Cyclotron Resonance Cell with Four Narrow Aperture Detection Electrodes published pages: 51-62, ISSN: 1044-0305, DOI: 10.1007/s13361-017-1817-6	Journal of The American Society for Mass Spectrometry 29/1	2019-05-28

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