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DNA Damage and Repair and its Impact on Healthy Ageing

Total Cost €


EC-Contrib. €






 Dam2Age project word cloud

Explore the words cloud of the Dam2Age project. It provides you a very rough idea of what is the project "Dam2Age" about.

life    conditional    variety    diseases    generalizing    progeroid    dietary    pharmacological    influence    assays    food    et    fold    largely    severity    transcription    2016    mouse    benefit    serves    powerful    al    mutants    models    determines    reached    untapped    200    reserves    delta    relevance    deficient    organ    pioneered    elucidate    controversial    counteracts    superior    dementia    retarded    genomic    normal    found    vermeij    stage    rate    declines    fig    accumulating    potent    delay    nature    unleashed    blocking    initially    parkinson    erc    sustained    remaining    organs    prevention    therapy    accelerated    cross    syndromes    neurodegeneration    enormous    stone    expression    extends    dysfunction    age    lesions    ercc1    see    dr    search    mimetics    fast    health    nutritional    connection    damage    underlying    urgently    repair    restriction    30    universal    segmental    dam2age    grant    xpg    mechanisms    emphasis    discovered    dna    aging    prominent    stochastic    disclosing    clinical    alzheimer    intervention    talk    gene    defect    mice    healthspan    stepping   

Project "Dam2Age" data sheet

The following table provides information about the project.


Organization address
postcode: 3015 GD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙251˙719 €
 EC max contribution 2˙251˙719 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

We pioneered an initially highly controversial connection between DNA damage and (accelerated) aging. In the previous ERC grant ‘DamAge’ we reached the stage that (segmental) aging in DNA repair-deficient mice can be largely controlled. The severity of the repair defect determines the rate of segmental aging; the repair pathways affected influence which organs age fast; conditional repair mutants allow targeting accelerated aging to any organ. Importantly, we found that dietary restriction (DR), the only universal intervention known to delay aging, extends remaining life- and healthspan in progeroid Ercc1Δ/- mutants by 200% (see Vermeij et al., Nature 2016 and fig.2). Also Xpg-/- progeroid repair mice strongly benefit from DR, generalizing this finding. The prominent Alzheimer- and Parkinson-like neurodegeneration is even retarded up to 30-fold(!) disclosing powerful untapped reserves unleashed by 30% less food, with enormous clinical potential. Also we discovered that in accelerated and normal aging gene expression declines due to accumulating stochastic transcription-blocking lesions and that DR counteracts genomic dysfunction. In Dam2Age we will focus on the cross-talk between DNA damage, aging and DR with emphasis on the relevance for normal aging, elucidate underlying mechanisms and use our unique -for DR research superior- mouse models and a variety of novel assays to search for effective nutritional-pharmacological DR mimetics. This serves as a stepping stone towards potent universal therapy for a range of repair-deficient progeroid syndromes and prevention of many aging-related diseases, most urgently dementia’s, to promote sustained health.


year authors and title journal last update
List of publications.
2019 Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling
published pages: , ISSN: 2190-5991, DOI: 10.1002/jcsm.12404
Journal of Cachexia, Sarcopenia and Muscle 2019-06-06

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The information about "DAM2AGE" are provided by the European Opendata Portal: CORDIS opendata.

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