Opendata, web and dolomites

ABIOS SIGNED

ABIOtic Synthesis of RNA: an investigation on how life started before biology existed

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ABIOS project word cloud

Explore the words cloud of the ABIOS project. It provides you a very rough idea of what is the project "ABIOS" about.

progress    model    storage    laboratory    calculations    enhanced    chemical    technological    ribonucleic    life    synthesize    thermally    abiotic    catalysts    incorporated    improvements    rationalize    mechanism    algorithms    machineries    bio    outcomes    basis    techniques    improvement    synthesis    monomers    alternative    stability    reveal    sugars    molecular    silico    ranging    forcefield    computational    questions    difficult    acid    setup    biological    employed    despite    cutting    sampling    disciplines    forms    original    scientists    comprehension    efficient    natural    edge    sciences    atom    poorly    orthogonal    understand    combining    thermophoresis    unsolved    critical    bond    backbone    significantly    polymers    precursors    overcoming    tolerance    rna    linkages    biopolymers    self    genetic    emergence    suggest    probably    quantum    phosphoester    obstacles    bonds    fascinating    linking    largely    dilute    origin    simulations    accumulation    catalysis   

Project "ABIOS" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙497˙031 €
 EC max contribution 1˙497˙031 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙031.00

Map

 Project objective

The emergence of life is one of the most fascinating and yet largely unsolved questions in the natural sciences, and thus a significant challenge for scientists from many disciplines. There is growing evidence that ribonucleic acid (RNA) polymers, which are capable of genetic information storage and self-catalysis, were involved in the early forms of life. But despite recent progress, RNA synthesis without biological machineries is very challenging. The current project aims at understanding how to synthesize RNA in abiotic conditions. I will solve problems associated with three critical aspects of RNA formation that I will rationalize at a molecular level: (i) accumulation of precursors, (ii) formation of a chemical bond between RNA monomers, and (iii) tolerance for alternative backbone sugars or linkages. Because I will study problems ranging from the formation of chemical bonds up to the stability of large biopolymers, I propose an original computational multi-scale approach combining techniques that range from quantum calculations to large-scale all-atom simulations, employed together with efficient enhanced-sampling algorithms, forcefield improvement, cutting-edge analysis methods and model development. My objectives are the following: 1 • To explain why the poorly-understood thermally-driven process of thermophoresis can contribute to the accumulation of dilute precursors. 2 • To understand why linking RNA monomers with phosphoester bonds is so difficult, to understand the molecular mechanism of possible catalysts and to suggest key improvements. 3 • To rationalize the molecular basis for RNA tolerance for alternative backbone sugars or linkages that have probably been incorporated in abiotic conditions. This unique in-silico laboratory setup should significantly impact our comprehension of life’s origin by overcoming major obstacles to RNA abiotic formation, and in addition will reveal significant orthogonal outcomes for (bio)technological applications.

 Publications

year authors and title journal last update
List of publications.
2019 Damien Laage, Guillaume Stirnemann
Effect of Ions on Water Dynamics in Dilute and Concentrated Aqueous Salt Solutions
published pages: 3312-3324, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.9b01053
The Journal of Physical Chemistry B 123/15 2019-09-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ABIOS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ABIOS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More