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ABIOS SIGNED

ABIOtic Synthesis of RNA: an investigation on how life started before biology existed

Total Cost €

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EC-Contrib. €

0

Partnership

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 ABIOS project word cloud

Explore the words cloud of the ABIOS project. It provides you a very rough idea of what is the project "ABIOS" about.

scientists    linking    poorly    monomers    quantum    biological    backbone    model    rna    acid    techniques    forms    largely    enhanced    questions    dilute    bonds    orthogonal    catalysts    bio    thermophoresis    understand    cutting    progress    calculations    life    sampling    molecular    despite    phosphoester    significantly    outcomes    linkages    catalysis    abiotic    atom    suggest    chemical    original    emergence    algorithms    simulations    technological    probably    improvements    ranging    edge    employed    rationalize    machineries    storage    reveal    efficient    setup    ribonucleic    tolerance    comprehension    obstacles    fascinating    combining    alternative    improvement    origin    genetic    silico    mechanism    polymers    computational    synthesis    critical    sciences    accumulation    incorporated    sugars    unsolved    laboratory    difficult    thermally    natural    stability    self    disciplines    biopolymers    bond    synthesize    basis    forcefield    overcoming    precursors   

Project "ABIOS" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙497˙031 €
 EC max contribution 1˙497˙031 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙031.00

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 Project objective

The emergence of life is one of the most fascinating and yet largely unsolved questions in the natural sciences, and thus a significant challenge for scientists from many disciplines. There is growing evidence that ribonucleic acid (RNA) polymers, which are capable of genetic information storage and self-catalysis, were involved in the early forms of life. But despite recent progress, RNA synthesis without biological machineries is very challenging. The current project aims at understanding how to synthesize RNA in abiotic conditions. I will solve problems associated with three critical aspects of RNA formation that I will rationalize at a molecular level: (i) accumulation of precursors, (ii) formation of a chemical bond between RNA monomers, and (iii) tolerance for alternative backbone sugars or linkages. Because I will study problems ranging from the formation of chemical bonds up to the stability of large biopolymers, I propose an original computational multi-scale approach combining techniques that range from quantum calculations to large-scale all-atom simulations, employed together with efficient enhanced-sampling algorithms, forcefield improvement, cutting-edge analysis methods and model development. My objectives are the following: 1 • To explain why the poorly-understood thermally-driven process of thermophoresis can contribute to the accumulation of dilute precursors. 2 • To understand why linking RNA monomers with phosphoester bonds is so difficult, to understand the molecular mechanism of possible catalysts and to suggest key improvements. 3 • To rationalize the molecular basis for RNA tolerance for alternative backbone sugars or linkages that have probably been incorporated in abiotic conditions. This unique in-silico laboratory setup should significantly impact our comprehension of life’s origin by overcoming major obstacles to RNA abiotic formation, and in addition will reveal significant orthogonal outcomes for (bio)technological applications.

 Publications

year authors and title journal last update
List of publications.
2019 Damien Laage, Guillaume Stirnemann
Effect of Ions on Water Dynamics in Dilute and Concentrated Aqueous Salt Solutions
published pages: 3312-3324, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.9b01053
The Journal of Physical Chemistry B 123/15 2019-09-26

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