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ABIOS SIGNED

ABIOtic Synthesis of RNA: an investigation on how life started before biology existed

Total Cost €

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EC-Contrib. €

0

Partnership

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 ABIOS project word cloud

Explore the words cloud of the ABIOS project. It provides you a very rough idea of what is the project "ABIOS" about.

simulations    synthesize    improvements    poorly    atom    backbone    disciplines    difficult    synthesis    linkages    sugars    questions    bond    rna    bio    technological    chemical    accumulation    computational    ribonucleic    laboratory    scientists    progress    original    largely    improvement    reveal    forcefield    tolerance    polymers    mechanism    overcoming    ranging    bonds    combining    rationalize    emergence    unsolved    techniques    obstacles    comprehension    despite    sciences    thermally    abiotic    forms    model    machineries    linking    efficient    silico    suggest    fascinating    stability    quantum    monomers    orthogonal    basis    natural    cutting    edge    origin    understand    life    setup    catalysts    molecular    enhanced    acid    probably    storage    dilute    self    critical    phosphoester    incorporated    outcomes    calculations    catalysis    employed    genetic    precursors    significantly    alternative    sampling    biological    biopolymers    algorithms    thermophoresis   

Project "ABIOS" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙497˙031 €
 EC max contribution 1˙497˙031 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙031.00

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 Project objective

The emergence of life is one of the most fascinating and yet largely unsolved questions in the natural sciences, and thus a significant challenge for scientists from many disciplines. There is growing evidence that ribonucleic acid (RNA) polymers, which are capable of genetic information storage and self-catalysis, were involved in the early forms of life. But despite recent progress, RNA synthesis without biological machineries is very challenging. The current project aims at understanding how to synthesize RNA in abiotic conditions. I will solve problems associated with three critical aspects of RNA formation that I will rationalize at a molecular level: (i) accumulation of precursors, (ii) formation of a chemical bond between RNA monomers, and (iii) tolerance for alternative backbone sugars or linkages. Because I will study problems ranging from the formation of chemical bonds up to the stability of large biopolymers, I propose an original computational multi-scale approach combining techniques that range from quantum calculations to large-scale all-atom simulations, employed together with efficient enhanced-sampling algorithms, forcefield improvement, cutting-edge analysis methods and model development. My objectives are the following: 1 • To explain why the poorly-understood thermally-driven process of thermophoresis can contribute to the accumulation of dilute precursors. 2 • To understand why linking RNA monomers with phosphoester bonds is so difficult, to understand the molecular mechanism of possible catalysts and to suggest key improvements. 3 • To rationalize the molecular basis for RNA tolerance for alternative backbone sugars or linkages that have probably been incorporated in abiotic conditions. This unique in-silico laboratory setup should significantly impact our comprehension of life’s origin by overcoming major obstacles to RNA abiotic formation, and in addition will reveal significant orthogonal outcomes for (bio)technological applications.

 Publications

year authors and title journal last update
List of publications.
2019 Damien Laage, Guillaume Stirnemann
Effect of Ions on Water Dynamics in Dilute and Concentrated Aqueous Salt Solutions
published pages: 3312-3324, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.9b01053
The Journal of Physical Chemistry B 123/15 2019-09-26

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The information about "ABIOS" are provided by the European Opendata Portal: CORDIS opendata.

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