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ABIOS SIGNED

ABIOtic Synthesis of RNA: an investigation on how life started before biology existed

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ABIOS project word cloud

Explore the words cloud of the ABIOS project. It provides you a very rough idea of what is the project "ABIOS" about.

emergence    improvement    catalysis    suggest    mechanism    ribonucleic    understand    setup    obstacles    unsolved    rationalize    computational    calculations    chemical    reveal    origin    catalysts    largely    overcoming    genetic    linking    thermophoresis    forms    alternative    incorporated    natural    atom    scientists    linkages    critical    technological    tolerance    efficient    simulations    techniques    ranging    life    enhanced    laboratory    backbone    precursors    progress    dilute    poorly    employed    disciplines    difficult    original    combining    basis    significantly    rna    improvements    storage    abiotic    synthesize    bond    synthesis    stability    silico    self    molecular    outcomes    biological    probably    cutting    edge    bio    biopolymers    quantum    polymers    fascinating    machineries    accumulation    sciences    monomers    model    despite    bonds    sugars    sampling    thermally    acid    questions    algorithms    forcefield    phosphoester    comprehension    orthogonal   

Project "ABIOS" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙497˙031 €
 EC max contribution 1˙497˙031 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙031.00

Map

 Project objective

The emergence of life is one of the most fascinating and yet largely unsolved questions in the natural sciences, and thus a significant challenge for scientists from many disciplines. There is growing evidence that ribonucleic acid (RNA) polymers, which are capable of genetic information storage and self-catalysis, were involved in the early forms of life. But despite recent progress, RNA synthesis without biological machineries is very challenging. The current project aims at understanding how to synthesize RNA in abiotic conditions. I will solve problems associated with three critical aspects of RNA formation that I will rationalize at a molecular level: (i) accumulation of precursors, (ii) formation of a chemical bond between RNA monomers, and (iii) tolerance for alternative backbone sugars or linkages. Because I will study problems ranging from the formation of chemical bonds up to the stability of large biopolymers, I propose an original computational multi-scale approach combining techniques that range from quantum calculations to large-scale all-atom simulations, employed together with efficient enhanced-sampling algorithms, forcefield improvement, cutting-edge analysis methods and model development. My objectives are the following: 1 • To explain why the poorly-understood thermally-driven process of thermophoresis can contribute to the accumulation of dilute precursors. 2 • To understand why linking RNA monomers with phosphoester bonds is so difficult, to understand the molecular mechanism of possible catalysts and to suggest key improvements. 3 • To rationalize the molecular basis for RNA tolerance for alternative backbone sugars or linkages that have probably been incorporated in abiotic conditions. This unique in-silico laboratory setup should significantly impact our comprehension of life’s origin by overcoming major obstacles to RNA abiotic formation, and in addition will reveal significant orthogonal outcomes for (bio)technological applications.

 Publications

year authors and title journal last update
List of publications.
2019 Damien Laage, Guillaume Stirnemann
Effect of Ions on Water Dynamics in Dilute and Concentrated Aqueous Salt Solutions
published pages: 3312-3324, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.9b01053
The Journal of Physical Chemistry B 123/15 2019-09-26

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The information about "ABIOS" are provided by the European Opendata Portal: CORDIS opendata.

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