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Malaria Parasite Networking: Discovering Modes of Cell-Cell Communication

Total Cost €


EC-Contrib. €






 MalPar.NET project word cloud

Explore the words cloud of the MalPar.NET project. It provides you a very rough idea of what is the project "MalPar.NET" about.

sense    millions    holistic    membranes    traits    human    people    look    roles    host    morphological    fact    episomal    hosts    transformations    unravelling    communication    therapeutics    malaria    greatest    barriers    density    genes    communicate    biology    enclosed    vesicles    exploring    parasitic    initial    data    complementary    humans    devastating    falciparum    small    immune    parasite    networks    cargo    inside    modes    plasmodium    area    secretion    layers    cells    sexual    signalling    thought    remarkable    series    networking    components    potentially    biological    discovered    clear    view    blood    possess    mosquitoes    red    rbc    opening    secure    effecting    innovative    worldwide    mutual    actions    caused    sensing    journey    exosome    cycle    decipher    overarching    releasing    tool    serve    multiple    despite    mode    explored    individual    coordinate    disease    cell    exchange    simultaneously    hundreds    mysteries    transmission    molecules    parasites    thereby   

Project "MalPar.NET" data sheet

The following table provides information about the project.


Organization address
address: HERZL STREET 234
postcode: 7610001

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00


 Project objective

Malaria, caused by Plasmodium falciparum, is a devastating parasitic disease effecting hundreds of millions of people worldwide. The parasite’s transmission cycle between humans and mosquitoes involves a remarkable series of morphological transformations. While it is clear that, for such a complex journey, the parasites must develop means to sense their host and coordinate their actions; these modes of communication remain one of the greatest mysteries in malaria biology. In fact, since an individual parasite is enclosed by three membranes inside its human host, the red blood cell (RBC), they were not thought to possess any communication ability. However, we discovered that these parasites, despite the multiple barriers, are able to communicate and exchange episomal genes by releasing exosome-like vesicles, thereby opening the exciting new field of malaria parasite communication. Our initial data demonstrate that these vesicles serve as a secure tool for the delivery of remarkable components. The overarching goal of this proposal is to take an innovative look at this under-investigated area of parasite sensing and signalling pathways and to decipher the multiple layers of parasite and host signalling networks. Specifically, we will determine the biological roles of Plasmodium exosome cargo components in: parasite-parasite communication - exploring parasite coordination traits in cell-density growth and sexual development (Objective 1); and parasite-host communication - unravelling the mutual communication of the parasite and its hosts, the red blood and immune cells (Objective 2). Simultaneously, we will exploit our experience in cell communication research to investigate the complementary, yet-to-be-explored mode of parasite communication via the secretion of small molecules (Objective 3). Our project will provide a holistic view of parasite communication networking while potentially providing, in the long term, novel targets for malaria therapeutics.


year authors and title journal last update
List of publications.
2018 Yifat Ofir-Birin, Paula Abou karam, Ariel Rudik, Tal Giladi, Ziv Porat, Neta Regev-Rudzki
Monitoring Extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01011
Frontiers in Immunology 9 2019-06-05

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