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ImPRESS SIGNED

Imaging Perfusion Restrictions from Extracellular Solid Stress

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EC-Contrib. €

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Project "ImPRESS" data sheet

The following table provides information about the project.

Coordinator
OSLO UNIVERSITETSSYKEHUS HF 

Organization address
address: KIRKEVEIEN 166 TARNBYGGET
city: OSLO
postcode: 450
website: http://www.oslo-universitetssykehus.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website https://www.ous-research.no/emblem/
 Total cost 1˙499˙638 €
 EC max contribution 1˙499˙638 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) coordinator 1˙499˙638.00

Map

 Project objective

Even the perfect cancer drug must reach its target to have an effect. The ImPRESS project main objective is to develop a novel imaging paradigm coined Restricted Perfusion Imaging (RPI) to reveal - for the first time in humans - vascular restrictions in solid cancers caused by mechanical solid stress, and use RPI to demonstrate that alleviating this force will repair the cancerous microenvironment and improve therapeutic response. Delivery of anti-cancer drugs to the tumor is critically dependent on a functional vascular bed. Developing biomarkers that can measure how mechanical forces in a solid tumor impair perfusion and promotes therapy resistance is essential for treatment of disease.

The ImPRESS project is based on the following observations; (I) pre-clinical work suggests that therapies targeting the tumor microenvironment and extracellular matrix may enhance drug delivery by decompressing tumor vessels; (II) results from animal models may not be transferable because compressive forces in human tumors in vivo can be many times higher; and (III) there are no available imaging technologies for medical diagnostics of solid stress in human cancers. Using RPI, ImPRESS will conduct a comprehensive series of innovative studies in brain cancer patients to answer three key questions: (Q1) Can we image vascular restrictions in human cancers and map how the vasculature changes with tumor growth or treatment? (Q2) Can we use medical engineering to image solid stress in vivo? (Q3) Can RPI show that matrix-depleting drugs improve patient response to conventional chemo- and radiation therapy as well as new targeted therapies?

The ImPRESS project holds a unique position to answer these questions by our unrivaled experience with advanced imaging of cancer patients. With successful delivery, ImPRESS will have a direct impact on patient treatment and establish an imaging paradigm that will pave the way for new scientific knowledge on how to revitalize cancer therapies.

 Publications

year authors and title journal last update
List of publications.
2018 Stelios Angeli, Kyrre E. Emblem, Paulina Due-Tonnessen, Triantafyllos Stylianopoulos
Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI
published pages: 664-673, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2018.08.032
NeuroImage: Clinical 20 2020-01-21
2018 Ingrid Digernes, Endre Grøvik, Line B. Nilsen, Cathrine Saxhaug, Oliver Geier, Edmund Reitan, Dag Ottar Sætre, Birger Breivik, Timothy Reese, Kari Dolven Jacobsen, Åslaug Helland, Kyrre Eeg Emblem
Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery
published pages: 559-567, ISSN: 2452-1094, DOI: 10.1016/j.adro.2018.05.005
Advances in Radiation Oncology 3/4 2020-01-21

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The information about "IMPRESS" are provided by the European Opendata Portal: CORDIS opendata.

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