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PolControl SIGNED

Engineering translation machinery to produce light-responsive protein-polymers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PolControl project word cloud

Explore the words cloud of the PolControl project. It provides you a very rough idea of what is the project "PolControl" about.

apparatus    cells    chemical    groups    proteins    discovered    incorporated    temporal    constitute    platform    limitation    incorporation    natural    macromolecular    site    spatio    co    create    translation    azobenzenes    cellular    elongation    functional    identical    azobenzene    protein    saas    containing    generating    efforts    generate    acids    substituted    universal    biomaterials    agents    synthetase    amino    overcome    self    visible    formulations    precise    hinders    biology    versatile    synthetic    classes    manipulation    utilize    methodology    demand    engineer    biophysical    biologically    marrying    extra    sequence    biological    chemistry    function    aminoacyl    genomic    evolution    materials    biomaterial    structures    responsive    physical    elucidate    machinery    engineering    assembly    limits    precludes    excludes    photochemical    multiple    select    light    complexity    smart    direct    synthesis    interrogation    libraries    technologies    deepen    trna    directing    polypeptide    components    inadequate   

Project "PolControl" data sheet

The following table provides information about the project.

Coordinator
BEN-GURION UNIVERSITY OF THE NEGEV 

Organization address
address: .
city: BEER SHEVA
postcode: 84105
website: www.bgu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙328˙712 €
 EC max contribution 1˙328˙712 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 1˙328˙712.00

Map

 Project objective

A general and versatile technology to engineer visible light-responsive biological agents will enable spatio-temporal manipulation and interrogation of proteins, pathways, and cells, and the design of “smart” biomaterials that can direct and respond to biological processes on-demand. Site specific incorporation of multiple visible-light-responsive chemical groups at the polypeptide level will constitute a universal methodology for precise production of light-responsive proteins and protein-based materials. However, inadequate engineering of the protein translation apparatus limits the number and complexity of chemical groups that can be incorporated into proteins as synthetic amino acids (sAAs). This limitation precludes the incorporation of recently discovered visible-light-responsive chemical groups, hinders protein engineering efforts, and excludes production of biomaterials in which multiple identical sAAs provide new physical or biophysical properties. We propose to overcome this challenge by generating a genomic-engineering based platform for co-evolution of multiple components of the translation machinery (the aminoacyl tRNA synthetase, tRNA, and elongation factor) to select for cellular machinery capable of multi-site incorporation of highly substituted azobenzenes with a range of biologically relevant photochemical properties. We will then utilize these translation systems to produce libraries of azobenzene-containing protein-based materials to elucidate the sequence-function requirements for directing light-responsive self-assembly of macromolecular structures, and to generate biomaterial formulations for control of various intra- and extra-cellular processes. By developing and marrying technologies in synthetic biology, chemistry, and biomaterials, this study will enable the synthesis of light-responsive proteins, deepen our understanding of natural and evolved translation systems, and create new classes of functional light-responsive biomaterials.

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The information about "POLCONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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