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PolControl SIGNED

Engineering translation machinery to produce light-responsive protein-polymers

Total Cost €


EC-Contrib. €






 PolControl project word cloud

Explore the words cloud of the PolControl project. It provides you a very rough idea of what is the project "PolControl" about.

utilize    interrogation    multiple    natural    materials    structures    manipulation    cells    visible    azobenzene    azobenzenes    containing    classes    platform    limitation    amino    overcome    direct    responsive    groups    biophysical    marrying    incorporated    libraries    polypeptide    cellular    create    discovered    precise    select    proteins    temporal    generate    hinders    assembly    photochemical    deepen    efforts    biomaterials    aminoacyl    constitute    identical    technologies    spatio    synthetase    formulations    extra    engineer    smart    biologically    translation    directing    biological    elongation    versatile    inadequate    incorporation    trna    generating    elucidate    evolution    protein    site    limits    co    saas    methodology    machinery    demand    apparatus    self    components    synthetic    complexity    excludes    functional    genomic    synthesis    substituted    universal    function    agents    biomaterial    engineering    biology    sequence    chemistry    chemical    physical    precludes    macromolecular    light    acids   

Project "PolControl" data sheet

The following table provides information about the project.


Organization address
address: .
postcode: 84105

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙328˙712 €
 EC max contribution 1˙328˙712 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 1˙328˙712.00


 Project objective

A general and versatile technology to engineer visible light-responsive biological agents will enable spatio-temporal manipulation and interrogation of proteins, pathways, and cells, and the design of “smart” biomaterials that can direct and respond to biological processes on-demand. Site specific incorporation of multiple visible-light-responsive chemical groups at the polypeptide level will constitute a universal methodology for precise production of light-responsive proteins and protein-based materials. However, inadequate engineering of the protein translation apparatus limits the number and complexity of chemical groups that can be incorporated into proteins as synthetic amino acids (sAAs). This limitation precludes the incorporation of recently discovered visible-light-responsive chemical groups, hinders protein engineering efforts, and excludes production of biomaterials in which multiple identical sAAs provide new physical or biophysical properties. We propose to overcome this challenge by generating a genomic-engineering based platform for co-evolution of multiple components of the translation machinery (the aminoacyl tRNA synthetase, tRNA, and elongation factor) to select for cellular machinery capable of multi-site incorporation of highly substituted azobenzenes with a range of biologically relevant photochemical properties. We will then utilize these translation systems to produce libraries of azobenzene-containing protein-based materials to elucidate the sequence-function requirements for directing light-responsive self-assembly of macromolecular structures, and to generate biomaterial formulations for control of various intra- and extra-cellular processes. By developing and marrying technologies in synthetic biology, chemistry, and biomaterials, this study will enable the synthesis of light-responsive proteins, deepen our understanding of natural and evolved translation systems, and create new classes of functional light-responsive biomaterials.

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The information about "POLCONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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