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CoSpaDD SIGNED

Competition for Space in Development and Diseases

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CoSpaDD" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/en/project/erc-2017-stg_cospadd/
 Total cost 1˙489˙147 €
 EC max contribution 1˙489˙147 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙489˙147.00

Map

 Project objective

Developing tissues have a remarkable plasticity illustrated by their capacity to regenerate and form normal organs despite strong perturbations. This requires the adjustment of single cell behaviour to their neighbours and to tissue scale parameters. The modulation of cell growth and proliferation was suggested to be driven by mechanical inputs, however the mechanisms adjusting cell death are not well known. Recently it was shown that epithelial cells could be eliminated by spontaneous live-cell delamination following an increase of cell density. Studying cell delamination in the midline region of the Drosophila pupal notum, we confirmed that local tissue crowding is necessary and sufficient to drive cell elimination and found that Caspase 3 activation precedes and is required for cell delamination. This suggested that a yet unknown pathway is responsible for crowding sensing and activation of caspase, which does not involve already known mechanical sensing pathways. Moreover, we showed that fast growing clones in the notum could induce neighbouring cell elimination through crowding-induced death. This suggested that crowding-induced death could promote tissue invasion by pretumoural cells. Here we will combine genetics, quantitative live imaging, statistics, laser perturbations and modelling to study crowding-induced death in Drosophila in order to: 1) find single cell deformations responsible for caspase activation; 2) find new pathways responsible for density sensing and apoptosis induction; 3) test their contribution to adult tissue homeostasis, morphogenesis and cell elimination coordination; 4) study the role of crowding induced death during competition between different cell types and tissue invasion 5) Explore theoretically the conditions required for efficient space competition between two cell populations. This project will provide essential information for the understanding of epithelial homeostasis, mechanotransduction and tissue invasion by tumoural cells

 Publications

year authors and title journal last update
List of publications.
2019 Alexis Matamoro-Vidal, Romain Levayer
Multiple Influences of Mechanical Forces on Cell Competition
published pages: R762-R774, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.06.030
Current Biology 29/15 2019-08-29
2019 Eduardo Moreno, Léo Valon, Florence Levillayer, Romain Levayer
Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation
published pages: 23-34.e8, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.11.007
Current Biology 29/1 2019-08-29
2019 Romain Levayer
Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth
published pages: , ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2019.05.004
Seminars in Cancer Biology 2019-08-29
2019 Léo Valon, Romain Levayer
Dying under pressure: cellular characterisation and in vivo functions of cell death induced by compaction
published pages: 51-66, ISSN: 0248-4900, DOI: 10.1111/boc.201800075
Biology of the Cell 111/3 2019-08-29

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The information about "COSPADD" are provided by the European Opendata Portal: CORDIS opendata.

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