Explore the words cloud of the DiPipe project. It provides you a very rough idea of what is the project "DiPipe" about.
The following table provides information about the project.
Coordinator |
UNIVERSITEIT ANTWERPEN
Organization address contact info |
Coordinator Country | Belgium [BE] |
Total cost | 178˙320 € |
EC max contribution | 178˙320 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2018 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2019 |
Duration (year-month-day) | from 2019-04-01 to 2021-03-31 |
Take a look of project's partnership.
# | ||||
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1 | UNIVERSITEIT ANTWERPEN | BE (ANTWERPEN) | coordinator | 178˙320.00 |
The transition metal-catalyzed direct functionalization of C-H bonds is a major research topic across the world. However selective (regio-, enantio-, diastereoselective) and efficient functionalization of C(sp3)-H bonds, remains a significant challenge: C(sp3)-H bonds are omnipresent in organic molecules and their dissociation energies are large. The use of directing groups (DGs) “guiding” the metal to specific C-H bonds and allowing intramolecular C-H bond activation, is a recognized general approach to address the selectivity challenge. However, their installation and removal add steps to the overall reaction sequence. This proposal aims to develop unprecedented regio- and diastereoselective transition metal-catalyzed functionalization of piperidine derivatives with haloalkenes making use of transient DGs, installed and removed in situ during catalysis. Access to a large number of substituted piperidines as well as known and new bicyclic scaffolds can be achieved via post-functionalization of the vinylpiperidine reaction products, making the aimed synthetic methodology potentially suitable for molecular library synthesis in drug discovery. A particularly challenging objective of the proposal is the remote (meta) functionalization with respect to the DG at C3 of the piperidine ring. Piperidine is chosen as a central heterocycle core in this application based on its importance in drug design and wide occurrence in commercial drugs (privileged scaffold).
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Sovan Biswas, Narendraprasad Reddy Bheemireddy, Mathias Bal, Ben F. Van Steijvoort, Bert U. W. Maes Directed C–H Functionalization Reactions with a Picolinamide Directing Group: Ni-Catalyzed Cleavage and Byproduct Recycling published pages: 13112-13123, ISSN: 0022-3263, DOI: 10.1021/ACS.JOC.9B02299 |
The Journal of Organic Chemistry 84/20 | 2020-02-10 |
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The information about "DIPIPE" are provided by the European Opendata Portal: CORDIS opendata.
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