Explore the words cloud of the DiPipe project. It provides you a very rough idea of what is the project "DiPipe" about.
The following table provides information about the project.
|Coordinator Country||Belgium [BE]|
|Total cost||178˙320 €|
|EC max contribution||178˙320 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-04-01 to 2021-03-31|
Take a look of project's partnership.
|1||UNIVERSITEIT ANTWERPEN||BE (ANTWERPEN)||coordinator||178˙320.00|
The transition metal-catalyzed direct functionalization of C-H bonds is a major research topic across the world. However selective (regio-, enantio-, diastereoselective) and efficient functionalization of C(sp3)-H bonds, remains a significant challenge: C(sp3)-H bonds are omnipresent in organic molecules and their dissociation energies are large. The use of directing groups (DGs) “guiding” the metal to specific C-H bonds and allowing intramolecular C-H bond activation, is a recognized general approach to address the selectivity challenge. However, their installation and removal add steps to the overall reaction sequence. This proposal aims to develop unprecedented regio- and diastereoselective transition metal-catalyzed functionalization of piperidine derivatives with haloalkenes making use of transient DGs, installed and removed in situ during catalysis. Access to a large number of substituted piperidines as well as known and new bicyclic scaffolds can be achieved via post-functionalization of the vinylpiperidine reaction products, making the aimed synthetic methodology potentially suitable for molecular library synthesis in drug discovery. A particularly challenging objective of the proposal is the remote (meta) functionalization with respect to the DG at C3 of the piperidine ring. Piperidine is chosen as a central heterocycle core in this application based on its importance in drug design and wide occurrence in commercial drugs (privileged scaffold).
|year||authors and title||journal||last update|
Sovan Biswas, Narendraprasad Reddy Bheemireddy, Mathias Bal, Ben F. Van Steijvoort, Bert U. W. Maes
Directed Câ€“H Functionalization Reactions with a Picolinamide Directing Group: Ni-Catalyzed Cleavage and Byproduct Recycling
published pages: 13112-13123, ISSN: 0022-3263, DOI: 10.1021/ACS.JOC.9B02299
|The Journal of Organic Chemistry 84/20||2020-02-10|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DIPIPE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "DIPIPE" are provided by the European Opendata Portal: CORDIS opendata.