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AstroNeuroCrosstalk SIGNED

Astrocyte-Neuronal Crosstalk in Obesity and Diabetes

Total Cost €

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EC-Contrib. €

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Partnership

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 AstroNeuroCrosstalk project word cloud

Explore the words cloud of the AstroNeuroCrosstalk project. It provides you a very rough idea of what is the project "AstroNeuroCrosstalk" about.

genome    neurons    obesity    circuits    human    highsugar    astrocyte    gliotransmitters    strategies    circulating    dissecting    prevalence    diabetes    mouse    inputs    models    efficient    anti    considerable    fight    disease    astrogliosis    ignoring    inspire    understand    urgent    cooperate    crosstalk    balance    shown    hypothetical    intensify    therapeutic    pathogenesis    potentially    model    hfhs    central    body    energy    weight    regulate    exposure    controls    health    interrupts    first    nervous    brain    underpinnings    emerged    regulating    contributes    uncover    neuronal    decades    rate    worldwide    assessing    hypothalamic    despite    gain    scientific    communication    prior    diet    actively    mechanisms    triggers    safe    association    prevention    active    astrocytes    fat    systemic    drugs    alarming    cns    describe    community    indicating    functional    release    molecular    nutrients    metabolism    treatment    astroglia    efforts    suggest    mutagenesis    neuron   

Project "AstroNeuroCrosstalk" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙938 €
 EC max contribution 1˙499˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙499˙938.00

Map

 Project objective

Despite considerable efforts aimed at prevention and treatment, the prevalence of obesity and type 2 diabetes has increased at an alarming rate worldwide over recent decades. Given the urgent need to develop safe and efficient anti-obesity drugs, the scientific community has to intensify efforts to better understand the mechanisms involved in the pathogenesis of obesity. Based on human genome-wide association studies and targeted mouse mutagenesis models, it has recently emerged that the brain controls most aspects of systemic metabolism and that obesity may be a brain disease. I have recently shown that like neurons, astrocytes also respond to circulating nutrients, and they cooperate with neurons to efficiently regulate energy metabolism. So far, the study of brain circuits controlling energy balance has focused on neurons, ignoring the presence and role of astrocytes. Importantly, our studies were the first to describe that exposure to a high-fat, highsugar (HFHS) diet triggers hypothalamic astrogliosis prior to significant body weight gain, indicating a potentially important role in promoting obesity. Overall, my recent findings suggest a novel model in which astrocytes are actively involved in the central nervous system (CNS) control of metabolism, likely including active crosstalk between astrocytes and neurons. To test this hypothetical model, I propose to develop a functional understanding of astroglia-neuronal communication in the CNS control of metabolism focusing on: 1) dissecting the ability of astrocytes to release gliotransmitters to neurons, 2) assessing how astrocytes respond to neuronal activity, and 3) determining if HFHS-induced astrogliosis interrupts this crosstalk and contributes to the development of obesity and type 2 diabetes. These studies aim to uncover the molecular underpinnings of astrocyte-neuron inputs regulating metabolism in health and disease so as to inspire and enable novel therapeutic strategies to fight diabetes and obesity.

 Publications

year authors and title journal last update
List of publications.
2019 Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
published pages: 7-14, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0286-y
Nature Neuroscience 22/1 2019-08-29

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