Explore the words cloud of the MOODSTRATIFICATION project. It provides you a very rough idea of what is the project "MOODSTRATIFICATION" about.
The following table provides information about the project.
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||5˙963˙750 €|
|EC max contribution||5˙963˙750 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2018-01-01 to 2022-06-30|
Take a look of project's partnership.
|1||ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM||NL (ROTTERDAM)||coordinator||1˙066˙250.00|
|2||ASSISTANCE PUBLIQUE HOPITAUX DE PARIS||FR (PARIS)||participant||688˙125.00|
|3||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||623˙500.00|
|4||OSPEDALE SAN RAFFAELE SRL||IT (MILANO)||participant||486˙562.00|
|5||AARHUS UNIVERSITET||DK (AARHUS C)||participant||480˙500.00|
|6||ACADEMISCH ZIEKENHUIS GRONINGEN||NL (GRONINGEN)||participant||471˙750.00|
|7||PRONTO DIAGNOSTICS LTD||IL (TEL AVIV)||participant||460˙000.00|
|8||ADVANCED PRACTICAL DIAGNOSTICS||BE (TURNHOUT)||participant||446˙500.00|
|9||WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER||DE (MUENSTER)||participant||428˙750.00|
|10||UNIVERSITAET ULM||DE (ULM)||participant||411˙500.00|
|11||ILTOO PHARMA||FR (PARIS)||participant||299˙062.00|
|12||LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN||DE (MUENCHEN)||participant||101˙250.00|
Objective: MOODSTRATIFICATION brings together 11 partners (psychiatrists, immunologists, epidemiologists, industry) from 7 countries stratifying patients with a major depressive episode on the basis of leukocyte immune profiles. The immune profiles were found in two previous EU projects, which also delivered the novel concept, that T cell defects with episodes of chronic mild inflammation are a causal factor for a large part of mood disorders. The immune profiles determine therapy choice with (combinations of) conventional and novel therapies with immune modulators (e.g. anti-inflammatory and T cell enforcement therapies). On the basis of recent data we expect that the present poor response rates of about 50% to anti-depressant therapy will improve considerably to 80-90%. Mood disorders are complex diseases with a high prevalence (12-20%) and are the second highest contributor to the number of years lived with disability worldwide. Work plan: MOODSTRATIFICATION firstly uses the large data sets and biobank of the two previous EU projects to further refine the already found immune profiles. Therefore the proposal further integrates existing and newly collected multidimensional, longitudinal clinical and laboratory data (-omics, FACS and serum multi-analytes) from these projects for further immune network analysis and computational modelling also taking female-male differences into account. Technologies to easily determine the immune profiles (a relatively small multi-analyte panel, Q-PCR kits on PAXGENE material) will together with industries be developed. Thereafter the efficacy of two novel T cell enforcing therapeutic approaches and the new concept of depression stratification on the basis of the immune profiles will be validated in three clinical proof-of-principle studies. Various national and international patient associations will be actively involved. Novelty: This is the first lab-based therapy stratification in psychiatry made ready for the clinic.
|Website update M18||Websites, patent fillings, videos etc.||2020-02-18 10:25:18|
|Website update M12||Websites, patent fillings, videos etc.||2020-02-18 10:25:18|
|Data management plan||Documents, reports||2020-02-18 10:25:18|
|Website update M1||Websites, patent fillings, videos etc.||2020-02-18 10:25:18|
|Website update M6||Websites, patent fillings, videos etc.||2020-02-18 10:25:18|
|Kick off report||Documents, reports||2020-02-18 10:25:18|
Take a look to the deliverables list in detail: detailed list of MOODSTRATIFICATION deliverables.
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The information about "MOODSTRATIFICATION" are provided by the European Opendata Portal: CORDIS opendata.
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