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MOODSTRATIFICATION SIGNED

Immune Signatures for Therapy Stratification in Major Mood Disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 MOODSTRATIFICATION project word cloud

Explore the words cloud of the MOODSTRATIFICATION project. It provides you a very rough idea of what is the project "MOODSTRATIFICATION" about.

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Project "MOODSTRATIFICATION" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.moodstratification.eu
 Total cost 5˙963˙750 €
 EC max contribution 5˙963˙750 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2017-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 1˙066˙250.00
2    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 688˙125.00
3    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 623˙500.00
4    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 486˙562.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 480˙500.00
6    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 471˙750.00
7    PRONTO DIAGNOSTICS LTD IL (TEL AVIV) participant 460˙000.00
8    ADVANCED PRACTICAL DIAGNOSTICS BE (TURNHOUT) participant 446˙500.00
9    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 428˙750.00
10    UNIVERSITAET ULM DE (ULM) participant 411˙500.00
11    ILTOO PHARMA FR (PARIS) participant 299˙062.00
12    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 101˙250.00

Map

 Project objective

Objective: MOODSTRATIFICATION brings together 11 partners (psychiatrists, immunologists, epidemiologists, industry) from 7 countries stratifying patients with a major depressive episode on the basis of leukocyte immune profiles. The immune profiles were found in two previous EU projects, which also delivered the novel concept, that T cell defects with episodes of chronic mild inflammation are a causal factor for a large part of mood disorders. The immune profiles determine therapy choice with (combinations of) conventional and novel therapies with immune modulators (e.g. anti-inflammatory and T cell enforcement therapies). On the basis of recent data we expect that the present poor response rates of about 50% to anti-depressant therapy will improve considerably to 80-90%. Mood disorders are complex diseases with a high prevalence (12-20%) and are the second highest contributor to the number of years lived with disability worldwide. Work plan: MOODSTRATIFICATION firstly uses the large data sets and biobank of the two previous EU projects to further refine the already found immune profiles. Therefore the proposal further integrates existing and newly collected multidimensional, longitudinal clinical and laboratory data (-omics, FACS and serum multi-analytes) from these projects for further immune network analysis and computational modelling also taking female-male differences into account. Technologies to easily determine the immune profiles (a relatively small multi-analyte panel, Q-PCR kits on PAXGENE material) will together with industries be developed. Thereafter the efficacy of two novel T cell enforcing therapeutic approaches and the new concept of depression stratification on the basis of the immune profiles will be validated in three clinical proof-of-principle studies. Various national and international patient associations will be actively involved. Novelty: This is the first lab-based therapy stratification in psychiatry made ready for the clinic.

 Deliverables

List of deliverables.
Website update M18 Websites, patent fillings, videos etc. 2020-02-18 10:25:18
Website update M12 Websites, patent fillings, videos etc. 2020-02-18 10:25:18
Data management plan Documents, reports 2020-02-18 10:25:18
Website update M1 Websites, patent fillings, videos etc. 2020-02-18 10:25:18
Website update M6 Websites, patent fillings, videos etc. 2020-02-18 10:25:18
Kick off report Documents, reports 2020-02-18 10:25:18

Take a look to the deliverables list in detail:  detailed list of MOODSTRATIFICATION deliverables.

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The information about "MOODSTRATIFICATION" are provided by the European Opendata Portal: CORDIS opendata.

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