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Chromosomal domain formation, compartmentalization and architecture

Total Cost €


EC-Contrib. €






 CHROMDOM project word cloud

Explore the words cloud of the CHROMDOM project. It provides you a very rough idea of what is the project "CHROMDOM" about.

scarce    complexity    reconstituted    nested    expand    insulator    confined    clusters    platform    proteins    tads    regulatory    form    dynamics    hierarchical    crosslinking    establishment    accessible    constricting    dimensional    maintenance    chromosomes    assay    domains    scaffold    bulk    demonstrated    otherwise    chromosomal    bound    molecule    structures    gene    hereditary    configuration    conformation    action    chromosome    smc    cohesin    inaccessible    previously    genetic    genomic    3c    reveal    basis    topologically    revealed    genes    resolve    distant    interphase    coining    organization    structural    fidelity    chiefly    molecular    throughput    experiments    curtains    details    loci    ctcf    interactions    mechanism    found    contact    technique    underlying    drive    dna    regulation    chromatin    capture    folding    eukaryotic    mutual    structure    complexes    insulators    compartments    single    hierarchically    biochemical    organizing    experimental    folded    techniques    compartment    scaffolding    loops   

Project "CHROMDOM" data sheet

The following table provides information about the project.


Organization address
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙350 €
 EC max contribution 1˙499˙350 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation. Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range of action. The folded structure of chromosomes through long-range loops enables mutual interactions of distant genomic loci that otherwise would not be in contact. While crosslinking-based chromosome conformation capture (3C) techniques have revealed the underlying structure of interphase chromosomes, the molecular mechanism of how chromosome-organizing proteins, such as the insulator CTCF or the structural maintenance of chromosomes (SMC) complex cohesin build the chromosomal scaffold and contribute to genomic organization, is not understood. Due to the complexity of the processes involved, biochemical information on how chromosomal proteins contribute to the establishment of TADs is scarce. I have previously demonstrated that single molecule techniques can be used to study the interactions of single cohesin complexes with DNA, chromatin and DNA-bound proteins and to resolve processes that are inaccessible in bulk biochemical experiments. In this project, I will use and expand the high-throughput single molecule technique of DNA curtains to study the molecular details of how chromosomal scaffolding proteins and genetic insulators form the basis for the three-dimensional folding of chromosomes. My experiments will build a novel experimental platform to study the dynamics of chromosomal configuration and maintenance in a reconstituted single molecule assay and will reveal the molecular details that drive the organization of chromosomes into hierarchically organized structures.


year authors and title journal last update
List of publications.
2019 Pilar Gutierrez-Escribano, Matthew D. Newton, Aida Llauró, Jonas Huber, Loredana Tanasie, Joseph Davy, Isabel Aly, Ricardo Aramayo, Alex Montoya, Holger Kramer, Johannes Stigler, David S. Rueda, Luis Aragon
A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules
published pages: eaay6804, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay6804
Science Advances 5/11 2020-03-05

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The information about "CHROMDOM" are provided by the European Opendata Portal: CORDIS opendata.

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