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CHROMDOM SIGNED

Chromosomal domain formation, compartmentalization and architecture

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CHROMDOM project word cloud

Explore the words cloud of the CHROMDOM project. It provides you a very rough idea of what is the project "CHROMDOM" about.

compartments    action    structural    found    domains    folded    nested    3c    smc    genomic    curtains    reconstituted    hereditary    dynamics    gene    proteins    regulation    reveal    ctcf    underlying    interactions    insulators    organizing    dna    scarce    complexes    conformation    chromatin    distant    experiments    regulatory    otherwise    maintenance    techniques    folding    contact    hierarchically    platform    details    biochemical    chromosomal    topologically    confined    interphase    throughput    scaffold    coining    basis    inaccessible    revealed    previously    tads    molecular    compartment    fidelity    clusters    mutual    organization    crosslinking    structure    scaffolding    genes    insulator    loops    cohesin    dimensional    eukaryotic    expand    assay    experimental    single    technique    chiefly    complexity    establishment    bulk    constricting    chromosome    molecule    chromosomes    resolve    bound    genetic    capture    configuration    accessible    structures    demonstrated    drive    loci    mechanism    hierarchical    form   

Project "CHROMDOM" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙350 €
 EC max contribution 1˙499˙350 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙499˙350.00

Map

 Project objective

The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation. Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range of action. The folded structure of chromosomes through long-range loops enables mutual interactions of distant genomic loci that otherwise would not be in contact. While crosslinking-based chromosome conformation capture (3C) techniques have revealed the underlying structure of interphase chromosomes, the molecular mechanism of how chromosome-organizing proteins, such as the insulator CTCF or the structural maintenance of chromosomes (SMC) complex cohesin build the chromosomal scaffold and contribute to genomic organization, is not understood. Due to the complexity of the processes involved, biochemical information on how chromosomal proteins contribute to the establishment of TADs is scarce. I have previously demonstrated that single molecule techniques can be used to study the interactions of single cohesin complexes with DNA, chromatin and DNA-bound proteins and to resolve processes that are inaccessible in bulk biochemical experiments. In this project, I will use and expand the high-throughput single molecule technique of DNA curtains to study the molecular details of how chromosomal scaffolding proteins and genetic insulators form the basis for the three-dimensional folding of chromosomes. My experiments will build a novel experimental platform to study the dynamics of chromosomal configuration and maintenance in a reconstituted single molecule assay and will reveal the molecular details that drive the organization of chromosomes into hierarchically organized structures.

 Publications

year authors and title journal last update
List of publications.
2019 Pilar Gutierrez-Escribano, Matthew D. Newton, Aida Llauró, Jonas Huber, Loredana Tanasie, Joseph Davy, Isabel Aly, Ricardo Aramayo, Alex Montoya, Holger Kramer, Johannes Stigler, David S. Rueda, Luis Aragon
A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules
published pages: eaay6804, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay6804
Science Advances 5/11 2020-03-05

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