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CHROMDOM SIGNED

Chromosomal domain formation, compartmentalization and architecture

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CHROMDOM project word cloud

Explore the words cloud of the CHROMDOM project. It provides you a very rough idea of what is the project "CHROMDOM" about.

expand    complexes    topologically    experimental    inaccessible    domains    form    previously    proteins    insulators    otherwise    folding    insulator    chromosomal    assay    genetic    genomic    establishment    accessible    contact    maintenance    constricting    revealed    crosslinking    compartment    demonstrated    scaffold    drive    details    molecular    chiefly    throughput    chromosome    curtains    technique    molecule    chromosomes    clusters    interphase    loops    hereditary    structure    resolve    genes    compartments    hierarchically    dimensional    scaffolding    reveal    single    cohesin    biochemical    regulatory    capture    bound    eukaryotic    mutual    complexity    bulk    distant    smc    tads    structures    experiments    fidelity    interactions    conformation    platform    structural    dynamics    mechanism    techniques    folded    3c    basis    gene    ctcf    action    loci    underlying    chromatin    regulation    organization    scarce    nested    dna    organizing    coining    configuration    found    reconstituted    hierarchical    confined   

Project "CHROMDOM" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙350 €
 EC max contribution 1˙499˙350 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙499˙350.00

Map

 Project objective

The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation. Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range of action. The folded structure of chromosomes through long-range loops enables mutual interactions of distant genomic loci that otherwise would not be in contact. While crosslinking-based chromosome conformation capture (3C) techniques have revealed the underlying structure of interphase chromosomes, the molecular mechanism of how chromosome-organizing proteins, such as the insulator CTCF or the structural maintenance of chromosomes (SMC) complex cohesin build the chromosomal scaffold and contribute to genomic organization, is not understood. Due to the complexity of the processes involved, biochemical information on how chromosomal proteins contribute to the establishment of TADs is scarce. I have previously demonstrated that single molecule techniques can be used to study the interactions of single cohesin complexes with DNA, chromatin and DNA-bound proteins and to resolve processes that are inaccessible in bulk biochemical experiments. In this project, I will use and expand the high-throughput single molecule technique of DNA curtains to study the molecular details of how chromosomal scaffolding proteins and genetic insulators form the basis for the three-dimensional folding of chromosomes. My experiments will build a novel experimental platform to study the dynamics of chromosomal configuration and maintenance in a reconstituted single molecule assay and will reveal the molecular details that drive the organization of chromosomes into hierarchically organized structures.

 Publications

year authors and title journal last update
List of publications.
2019 Pilar Gutierrez-Escribano, Matthew D. Newton, Aida Llauró, Jonas Huber, Loredana Tanasie, Joseph Davy, Isabel Aly, Ricardo Aramayo, Alex Montoya, Holger Kramer, Johannes Stigler, David S. Rueda, Luis Aragon
A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules
published pages: eaay6804, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay6804
Science Advances 5/11 2020-03-05

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