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HoliFAB SIGNED

Holistic digital-to-physical prototyping and production pilot for microfluidic MEMS

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HoliFAB" data sheet

The following table provides information about the project.

Coordinator
FLUIGENT SA 

Organization address
address: 57-77 AVENUE DE FONTAINEBLEAU
city: LE KREMLIN-BICETRE
postcode: 94270
website: www.fluigent.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://holifab.eu/
 Total cost 9˙304˙795 €
 EC max contribution 7˙152˙981 € (77%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-PILOTS-2017
 Funding Scheme IA
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FLUIGENT SA FR (LE KREMLIN-BICETRE) coordinator 1˙290˙601.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 1˙611˙616.00
3    EV GROUP E. THALLNER GMBH AT (ST FLORIAN AM INN) participant 888˙072.00
4    microLIQUID sl ES (Arrasate-Mondragon) participant 815˙500.00
5    SCULPTEO FR (VILLEJUIF) participant 606˙375.00
6    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 520˙467.00
7    MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH DE (BERLIN) participant 429˙142.00
8    T.E. LABORATORIES LIMITED IE (TULLOW) participant 332˙062.00
9    MYPA INYECCION SL ES (MARIA DE HUERVA) participant 296˙684.00
10    TECH2MARKET SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA PL (BUSKO-ZDROJ) participant 200˙830.00
11    MYPA MOLDES SOCIEDAD LIMITADA ES (ZARAGOZA) participant 161˙630.00

Map

 Project objective

The project aims at a holistic new design strategy, coordinated pilot lines and business model for the prototyping, fabrication and commercialization of polymer-based microfluidic systems. It stems from the recognition that a microfluidic chip is a key part of a microfluidic MEMS, but only a part. Many limitations to fast prototyping, industrialization and ultimate performances lie not in the chip itself, but in the world-to-chip connections and integration of multiple external components. We shall address in a single strategy the streamlined construction of whole microfluidic systems, starting from existing pilot lines in injection moulding, 3D printing and instrument construction. This will specific innovations. First, the resolution of 3D printing will be increased by a factor at least 10, down to 1~3µm, with a throughput 10 to 100x higher than that of current high resolution 3D printing machines, to support the flexible production of chips with complex 3D architectures. New soft, bio, environment-friendly and/or active materials will be integrated in the production chain using a technology patented by the partners. Large-scale markets requiring mass production at the lowest cost will be addressed by a fully integrated pilot line, streamlining injection moulding of raw chips, reagents and components integration, sealing and quality control. Inter-compatibility between 3D printing and injection moulding, regarding architectures and materials, will be developed to accelerate the prototype to product value chain. After development and upscaling, the technology will be demonstrated and qualified in operational environment by end-users with lab-on-chip applications in health (cancer diagnosis, organ-on chip) and environment (water control). Partners jointly have the production lines onto which the project’s innovation will be readily integrated, helping microfluidics to become a major component of the 4th industrial revolution.

 Publications

year authors and title journal last update
List of publications.
2018 Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin
Two-photon lithography and microscopy of 3D hydrogel scaffolds for neuronal cell growth
published pages: 27009, ISSN: 2057-1976, DOI: 10.1088/2057-1976/aaab93
Biomedical Physics & Engineering Express 4/2 2019-12-16
2019 Justine Creff, Rémi Courson, Thomas Mangeat, Julie Foncy, Sandrine Souleille, C. Thibault, Arnaud Besson, Laurent Malaquin
Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography
published pages: 119404, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119404
Biomaterials 221 2019-12-16
2018 Petra Juskova, Alexis Ollitrault, Marco Serra, Jean-Louis Viovy, Laurent Malaquin
Resolution improvement of 3D stereo-lithography through the direct laser trajectory programming: Application to microfluidic deterministic lateral displacement device
published pages: 239-247, ISSN: 0003-2670, DOI: 10.1016/j.aca.2017.11.062
Analytica Chimica Acta 1000 2019-12-16
2018 Andrew Donohoe, Gareth Lacour, Peter McCluskey, Dermot Diamond, Margaret McCaul
Development of a Cost-Effective Sensing Platform for Monitoring Phosphate in Natural Waters
published pages: 57, ISSN: 2227-9040, DOI: 10.3390/chemosensors6040057
Chemosensors 6/4 2019-10-30
2018 Angelo Accardo, Rémi Courson, Roberto Riesco, Vincent Raimbault, Laurent Malaquin
Direct laser fabrication of meso-scale 2D and 3D architectures with micrometric feature resolution
published pages: 440-446, ISSN: 2214-8604, DOI: 10.1016/j.addma.2018.04.027
Additive Manufacturing 22 2019-10-30
2018 Eoin Murray, Yan Li, Sinead A. Currivan, Breda Moore, Aoife Morrin, Dermot Diamond, Mirek Macka, Brett Paull
Miniaturized capillary ion chromatograph with UV light-emitting diode based indirect absorbance detection for anion analysis in potable and environmental waters
published pages: 3224-3231, ISSN: 1615-9306, DOI: 10.1002/jssc.201800495
Journal of Separation Science 41/16 2019-10-30
2019 Roberto Riesco, Louisa Boyer, Sarah Blosse, Pauline M. Lefebvre, Pauline Assemat, Thierry Leichlé, Angelo Accardo, Laurent Malaquin
Water-in-PDMS emulsion templating of highly interconnected porous architectures for 3D cell culture
published pages: , ISSN: 1944-8244, DOI: 10.1021/acsami.9b07564
ACS Applied Materials & Interfaces 2019-10-30
2018 Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin
Direct laser fabrication of free-standing PEGDA-hydrogel scaffolds for neuronal cell growth
published pages: 315-316, ISSN: 1369-7021, DOI: 10.1016/j.mattod.2018.02.004
Materials Today 21/3 2019-10-30

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The information about "HOLIFAB" are provided by the European Opendata Portal: CORDIS opendata.

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