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MIRACLE SIGNED

Mid-infrared arthroscopy innovative imaging system for real-time clinical in depth examination and diagnosis of degenerative joint diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 MIRACLE project word cloud

Explore the words cloud of the MIRACLE project. It provides you a very rough idea of what is the project "MIRACLE" about.

   surgeon    imaging    combining    trl4    market    19    industry    diagnostics    valued    subjective    quantitative    evaluation    pain    biodiagnostics    diagnosis    poor    diseases    visual    osteoarthritis    combiner    surgery    452    accurate    2015    elderly    disability    medical    probing    ultimately       untreated    population    feasibility    billion    oa    device    movement    add    biochemical    reaching    quantum    patient    radiation    mir    patients    prototyped    cartilage    demonstrated    wellbeing    mid    repeatability    tool    health    people    42    laser    efficient    strives    prevalent    orthopedic    ageing    articular    tissue    limitation    probe    minimally    infrared    trl    joint    progress    invasive    million    commercialization    miracle    replacement    inspection    components    cascade    care    decision    degenerative    intended    globally    diagnostic    arthroscopy    affordable    manual    injury    chip    sensing    precedes    placed    first    array    constitutes    coupling    photonics    242    beam    public    correctly   

Project "MIRACLE" data sheet

The following table provides information about the project.

Coordinator
OULUN YLIOPISTO 

Organization address
address: PENTTI KAITERAN KATU 1
city: OULU
postcode: 90014
website: www.oulu.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Project website http://miracleproject.eu/
 Total cost 6˙960˙845 €
 EC max contribution 6˙133˙635 € (88%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2017-1
 Funding Scheme IA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OULUN YLIOPISTO FI (OULU) coordinator 1˙146˙325.00
2    UNIVERSITAET ULM DE (ULM) participant 842˙500.00
3    NANOPLUS NANOSYSTEMS AND TECHNOLOGIES GMBH DE (GERBRUNN) participant 797˙204.00
4    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 585˙856.00
5    NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET NO (AS) participant 538˙431.00
6    OPTOPRECISION GMBH DE (BREMEN) participant 470˙312.00
7    INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA PT (PORTO) participant 361˙530.00
8    IRIS TECHNOLOGY SOLUTIONS, SOCIEDAD LIMITADA ES (MADRID) participant 352˙450.00
9    ART PHOTONICS DE (BERLIN) participant 310˙187.00
10    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 293˙376.00
11    POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA FI (KYS) participant 173˙750.00
12    PHOTONICS FINLAND FI (Joensuu) participant 106˙367.00
13    UNIVERSIDADE CATOLICA PORTUGUESA PT (LISBOA) participant 77˙845.00
14    ASOCIACION ESPANOLA DE NORMALIZACION ES (MADRID) participant 77˙500.00

Map

 Project objective

MIRACLE will take towards commercialization the first mid-infrared (MIR) arthroscopy probe for in-depth evaluation of articular cartilage enabling early diagnosis of degenerative joint diseases such as osteoarthritis (OA). The proposed device is intended for use during a minimally invasive surgery (arthroscopy). Currently, the surgeon’s decision-making is based on visual inspection and manual probing of the cartilage tissue which is highly subjective and of poor repeatability. Untreated or not-correctly treated joint injury will most likely progress towards OA, which will lead to joint pain, movement limitation, joint failure, and ultimately disability and joint replacement. OA constitutes a major challenge for the health systems and affects 242 million people globally. Moreover, OA is highly prevalent in Europe with an estimated 19.7-42.3% in the elderly population. MIRACLE concept is to access the biochemical on articular cartilage, which precedes OA. The feasibility of this approach as a diagnostic method has been demonstrated by MIRACLE consortium (TRL4). MIRACLE has also prototyped a MIR-probe with potential use for diagnostics (TRL4). By technology development reaching TRL 6-7, MIRACLE will bring to the arthroscopy market the first MIR-based probe providing an unique, accurate and quantitative diagnostic tool for the orthopedic surgeon. This will be achieved combining three novel photonics components: (i) a quantum cascade laser array tailored to biodiagnostics, (ii) an on-chip beam combiner for efficient radiation coupling, and (iii) MIR sensing probe for imaging. These components will be integrated in a medical device to be placed in the arthroscopy market (valued at $4 billion in 2015). In addition to add value to the European medical equipment industry, MIRACLE strives towards cost reduction of OA patients (currently costs/patient/year €10,452) contributing to more affordable public health care and promoting wellbeing in the European ageing population.

 Publications

year authors and title journal last update
List of publications.
2019 Julian Haas, Philipp Artmann, Boris Mizaikoff
Mid-infrared GaAs/AlGaAs micro-ring resonators characterized via thermal tuning
published pages: 8594-8599, ISSN: 2046-2069, DOI: 10.1039/c8ra10395j
RSC Advances 9/15 2020-03-25
2019 Julian Haas, Anja Müller, Lorenz Sykora, Boris Mizaikoff
Analytical performance of μ-groove silicon attenuated total reflection waveguides
published pages: 3398-3404, ISSN: 0003-2654, DOI: 10.1039/c9an00417c
The Analyst 144/10 2020-03-25
2019 Ángela I. López‐Lorente, Pei Wang, Svenja Stein, Jonas Balko, Rui Lu, Lutz Dürselen, Boris Mizaikoff
Surface analysis of sheep menisci after meniscectomy via infrared attenuated total reflection spectroscopy
published pages: e201800429, ISSN: 1864-063X, DOI: 10.1002/jbio.201800429
Journal of Biophotonics 2020-03-25
2018 Pei Wang, Jonas Balko, Rui Lu, Ángela I. López-Lorente, Lutz Dürselen, Boris Mizaikoff
Analysis of human menisci degeneration via infrared attenuated total reflection spectroscopy
published pages: 5023-5029, ISSN: 0003-2654, DOI: 10.1039/c8an00924d
The Analyst 143/20 2020-03-25
2019 Julian Haas, Michael Pleyer, Josephine Nauschütz, Johannes Koeth, Markus Nägele, Olga Bibikova, Tatiana Sakharova, Viacheslav Artyushenko, Boris Mizaikoff
iBEAM: substrate-integrated hollow waveguides for efficient laser beam combining
published pages: 23059, ISSN: 1094-4087, DOI: 10.1364/oe.27.023059
Optics Express 27/16 2020-03-25

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