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OncoSeq

OncoSeq: an innovative single-cell system for immunomonitoring

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OncoSeq project word cloud

Explore the words cloud of the OncoSeq project. It provides you a very rough idea of what is the project "OncoSeq" about.

tool    biopsy    barcoding    cytometry    immunity    plays    evoevo    company    thousands    le    immunotherapy    diagnosis    cancer    disease    maps    readout    progression    create    consumables    context    immunotherapies    liquid    single    erc    rna    ngs    tumor    follow    host    powerful    cytof    cell    licensing    droplet    industrial    infiltrate    multiplexing    100s    sequencing    markets    mass    quantity    plan    sale    tens    decision    site    prototype    immuno    exist    circulating    specialising    phenotype    cytometer    central    immune    transferred    once    tumour    seq    instruments    markers    prognosis    simultaneous    patient    flow    internal    phenotypic    resolution    adapt    genotype    infiltrating    validated    vital    oncoseq    entirely    creation    capacity    output    prognostic    cells    throughput    molecular    marker    diagnostic    quality    monitoring    generation    oncology    transcriptomic    strategies    spectrometry    microfluidics    clinical    stratification    fluorescence    ultimately    transcriptome   

Project "OncoSeq" data sheet

The following table provides information about the project.

Coordinator
PARMENIDES STIFTUNG 

Organization address
address: KIRCHPLATZ 1
city: MUNCHEN
postcode: 82049
website: www.parmenides-foundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PARMENIDES STIFTUNG DE (MUNCHEN) coordinator 41˙250.00
2    ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS FR (PARIS) participant 108˙750.00

Map

 Project objective

Host immunity plays a central and complex role in tumour progression, and the quality and quantity of immune infiltrate at the tumour site is used as a prognostic marker of cancer progression. Therefore, detailed single-cell analysis of tumor infiltrating immune cells, and ultimately liquid biopsy of circulating immune cells, is of vital importance for the development of new and improved immunotherapy strategies, and for diagnosis, prognosis, patient stratification and follow-up. We propose in OncoSeq to adapt the droplet barcoding microfluidics system, an output from the ERC EVOEVO project, to develop a novel “molecular cytometer” for high-throughput transcriptomic and phenotypic analysis, at the single-cell level, of tumor infiltrating or circulating immune cells. Readout of genotype and phenotype will be entirely based on next generation sequencing (NGS) allowing higher phenotypic multiplexing capacity (100s of phenotypic markers) than fluorescence (Flow cytometry) or mass spectrometry (CyTOF) based approaches (≤40 markers) and simultaneous RNA-sequencing (RNA-seq), allowing the creation of high-resolution phenotype-transcriptome maps for tens of thousands of single cells. This will be a powerful tool for cancer prognosis, clinical decision making and monitoring of disease progression, especially in the context of immunotherapy. So far, no such diagnostic instruments, enabling high-throughput single-cell phenotypic and transcriptomic analysis, exist. The technology developed will be transferred to our industrial partner through licensing for internal development of novel immunotherapies. In addition, once the prototype system is fully validated, we plan, with our industrial partners, to create a new company specialising in the sale of instruments and associated consumables for clinical single-cell immuno-monitoring for the research and clinical oncology markets.

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The information about "ONCOSEQ" are provided by the European Opendata Portal: CORDIS opendata.

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