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Tissue-derived acellular micro-scaffold technology reducing or eliminating diabetics’ dependence oninsulin therapy

Total Cost €


EC-Contrib. €






 Io-EMP project word cloud

Explore the words cloud of the Io-EMP project. It provides you a very rough idea of what is the project "Io-EMP" about.

transplanted    autoimmune    tissue    recipients    environment    lifetime    stromal    organ    appropriate    cells    composition    bn    t1dm    damage    destruction    pancreas    transplantation    careful    regime    performance    medical    researched    onset    producing    scaffold    worldwide    acellular    chronic    basic    mitigate    islets    function    platform    procedure    free    10    mn    seeded    extend    14    life    treatment    cadavers    micro    alone    reduce    pancreatic    premature    afflicted    eliminate    harvesting    24hrs    mission    nutrients    diagnosed    islet    annually    prevent    prepare    complications    source    uncertain    insulinproducing    unstable    income    properly    proprietary    people    injecting    diabetes    stop    harvested    clusters    naked    house    17    diabetics    stroma    death    connective    70    preserve    beta    millions    immediately    microns    cell    scaffolds    attempt    therapy    cardiovascular    nerves    insulin    immunosuppression    dependence    eyes    followed    lifestyle    functioning    betalin    gases    disease    almost    architecture    premise    lost    daily    150    kidneys    with    80   

Project "Io-EMP" data sheet

The following table provides information about the project.


Organization address
postcode: 5268101
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.5. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced manufacturing and processing)
2. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
3. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
4. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2018-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BETALIN THERAPEUTICS LTD IL (RAMAT GAM) coordinator 50˙000.00


 Project objective

Betalin’s mission is to provide a tissue-derived acellular micro-scaffold that will extend the life and the insulin-producing performance of transplanted beta cells in order to reduce or eliminate the dependence of some diabetics on insulin therapy. Type 1 Diabetes is a chronic disease that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Its cause is still uncertain and there is no known way to prevent its onset. With~70,000 new cases diagnosed each year, it is estimated that ~17 mn people worldwide are afflicted with T1DM. In the US alone, T1DM results in $14.4 bn in medical costs and lost income annually. Type 1 diabetics face a lifetime regime of insulin therapy and very careful lifestyle management in an attempt to mitigate the long-term complications associated with T1DM such as cardiovascular disease, damage to the eyes, kidneys and nerves, and premature death. In recent years islet transplantation has been researched as a treatment for T1DM. The procedure involves injecting millions of islets (the pancreatic cell clusters that “house” the insulinproducing beta cells) harvested from cadavers, followed by immunosuppression therapy. Islet transplantation is a promising approach but the naked islets are very unstable: they must be transplanted almost immediately after harvesting and up to 80% of the transplanted islets stop functioning within 24hrs. The result is that, after five years, less than 10% of the recipients are free of daily insulin treatment. Betalin’s technology is based on the premise that in order for beta cells to function properly it is necessary to provide an appropriate stromal (connective tissue) micro-environment. The proprietary platform technology is a method to prepare acellular organ-derived micro-scaffolds that preserve the architecture and the basic composition of organ stroma and ensure that no seeded cell will be more than 150 microns from a source of nutrients and gases.

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The information about "IO-EMP" are provided by the European Opendata Portal: CORDIS opendata.

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