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conVIRgens SIGNED

De- and reconstructing virulence strategies of fungal plant pathogens

Total Cost €

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EC-Contrib. €

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Partnership

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 conVIRgens project word cloud

Explore the words cloud of the conVIRgens project. It provides you a very rough idea of what is the project "conVIRgens" about.

agriculture    utilize    ustilago    enormous    tissue    reconstruction    fungi    pioneering    amenable    fungal    cultivation    plants    plant    previously    insights    disease    grown    organisms    serve    agent    accessibility    synthetic    virulence    reverse    hosts    maydis    sources    worldwide    impossible    strategies    obligate    causal    consecutive    smut    thereby    deconstruction    subsequent    genomics    powdery    corn    fundamentally    economically    complete    repertoire    deletion    threats    enterprise    causing    losses    mildew    mechanistic    stage    sustainable    proteins    functional    convirgens    mutants    accessible    proliferation    reprogram    constraint    excellent    yeast    strains    haploid    structures    biotrophic    arsenal    effector    model    biotrophs    culture    termed    pathogenicity    secrete    generate    first    colonize    modification    stimulate    deconstructed    spatiotemporal    microbial    reconstruct    eukaryotic    severe    modules    protection    effectors    pathogens    tremendous    rusts    transcriptomics    chassis    tools    crop    infection    living    genetic    combination    contrast    disarmed    genetics   

Project "conVIRgens" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET ZU KOELN 

Organization address
address: ALBERTUS MAGNUS PLATZ
city: KOELN
postcode: 50931
website: www.uni-koeln.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙922˙000 €
 EC max contribution 1˙922˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET ZU KOELN DE (KOELN) coordinator 1˙922˙000.00

Map

 Project objective

Fungal pathogens are enormous threats to plants, causing tremendous losses in worldwide crop production. Mechanistic understanding of fungal virulence is crucial to developing novel plant protection strategies in sustainable agriculture. Biotrophic pathogens colonize living plant tissue and reprogram their hosts to stimulate proliferation and development of infection structures. To promote infection, fungal pathogens secrete sets of virulence proteins termed “effectors” in a spatiotemporal program. Many economically relevant biotrophs like rusts and powdery mildew fungi are obligate pathogens. These organisms cannot be grown in culture and are not amenable to reverse genetics, which is a severe constraint for current research. In contrast, the biotrophic smut fungi have a haploid yeast stage, which allows simple cultivation and genetic modification. The causal agent of corn smut disease, Ustilago maydis, is one of the best-established model organisms for fungal genetics. This project aims to utilize the excellent genetic accessibility of U. maydis to approach a previously impossible, pioneering enterprise: the synthetic reconstruction of eukaryotic plant pathogens. In a first step, fungal virulence will be deconstructed by consecutive deletion of the U. maydis effector repertoire to generate disarmed mutants. These strains will serve as chassis for subsequent reconstruction of fungal pathogenicity from different sources. A combination of transcriptomics and comparative genomics will help to define synthetic effector modules to reconstruct virulence in the chassis strains. Deconstruction of U. maydis virulence will identify a complete arsenal of fungal virulence factors. Reconstruction of virulence will show how effector modules determine fungal virulence, including those of the previously not accessible obligate biotrophs. conVIRgens will thereby provide fundamentally new insights and novel functional tools towards the understanding of microbial virulence.

 Publications

year authors and title journal last update
List of publications.
2019 Weiliang Zuo, Jasper Depotter, Gunther Doehlemann
Cas9HF1 enhanced specificity in Ustilago maydis
published pages: , ISSN: , DOI: 10.1101/671826
2019-12-17
2019 Jasper R L Depotter, Gunther Doehlemann
Target the core: durable plant resistance against filamentous plant pathogens through effector recognition
published pages: , ISSN: 1526-498X, DOI: 10.1002/ps.5677
Pest Management Science 2019-12-17

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