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conVIRgens SIGNED

De- and reconstructing virulence strategies of fungal plant pathogens

Total Cost €

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EC-Contrib. €

0

Partnership

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 conVIRgens project word cloud

Explore the words cloud of the conVIRgens project. It provides you a very rough idea of what is the project "conVIRgens" about.

microbial    genomics    hosts    contrast    grown    worldwide    cultivation    accessible    reverse    tremendous    functional    serve    biotrophic    reprogram    complete    infection    genetics    mildew    first    reconstruction    impossible    combination    colonize    proliferation    eukaryotic    tools    haploid    modification    protection    convirgens    accessibility    yeast    ustilago    pathogenicity    genetic    disarmed    generate    smut    threats    stimulate    enormous    spatiotemporal    amenable    organisms    fundamentally    economically    causal    severe    repertoire    obligate    subsequent    deletion    sources    excellent    thereby    previously    tissue    reconstruct    disease    fungi    deconstructed    insights    crop    deconstruction    effector    structures    mutants    constraint    enterprise    arsenal    maydis    agriculture    termed    fungal    causing    strains    transcriptomics    powdery    utilize    biotrophs    proteins    model    synthetic    virulence    consecutive    pathogens    corn    stage    losses    secrete    rusts    plants    modules    effectors    agent    chassis    living    sustainable    strategies    plant    culture    pioneering    mechanistic   

Project "conVIRgens" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET ZU KOELN 

Organization address
address: ALBERTUS MAGNUS PLATZ
city: KOELN
postcode: 50931
website: www.uni-koeln.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙922˙000 €
 EC max contribution 1˙922˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET ZU KOELN DE (KOELN) coordinator 1˙922˙000.00

Map

 Project objective

Fungal pathogens are enormous threats to plants, causing tremendous losses in worldwide crop production. Mechanistic understanding of fungal virulence is crucial to developing novel plant protection strategies in sustainable agriculture. Biotrophic pathogens colonize living plant tissue and reprogram their hosts to stimulate proliferation and development of infection structures. To promote infection, fungal pathogens secrete sets of virulence proteins termed “effectors” in a spatiotemporal program. Many economically relevant biotrophs like rusts and powdery mildew fungi are obligate pathogens. These organisms cannot be grown in culture and are not amenable to reverse genetics, which is a severe constraint for current research. In contrast, the biotrophic smut fungi have a haploid yeast stage, which allows simple cultivation and genetic modification. The causal agent of corn smut disease, Ustilago maydis, is one of the best-established model organisms for fungal genetics. This project aims to utilize the excellent genetic accessibility of U. maydis to approach a previously impossible, pioneering enterprise: the synthetic reconstruction of eukaryotic plant pathogens. In a first step, fungal virulence will be deconstructed by consecutive deletion of the U. maydis effector repertoire to generate disarmed mutants. These strains will serve as chassis for subsequent reconstruction of fungal pathogenicity from different sources. A combination of transcriptomics and comparative genomics will help to define synthetic effector modules to reconstruct virulence in the chassis strains. Deconstruction of U. maydis virulence will identify a complete arsenal of fungal virulence factors. Reconstruction of virulence will show how effector modules determine fungal virulence, including those of the previously not accessible obligate biotrophs. conVIRgens will thereby provide fundamentally new insights and novel functional tools towards the understanding of microbial virulence.

 Publications

year authors and title journal last update
List of publications.
2019 Weiliang Zuo, Jasper Depotter, Gunther Doehlemann
Cas9HF1 enhanced specificity in Ustilago maydis
published pages: , ISSN: , DOI: 10.1101/671826
2019-12-17
2019 Jasper R L Depotter, Gunther Doehlemann
Target the core: durable plant resistance against filamentous plant pathogens through effector recognition
published pages: , ISSN: 1526-498X, DOI: 10.1002/ps.5677
Pest Management Science 2019-12-17

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