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Dendrites and memory: role of dendritic spikes in information coding by hippocampal CA3 pyramidal neurons

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Project "DeCode" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Total cost 1˙990˙314 €
 EC max contribution 1˙990˙314 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 1˙990˙314.00

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 Project objective

The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood. In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be essential for associative memory. Current models of the associative functions of CA3 are mainly based on plasticity of these synaptic connections. Recent work by us and others however suggests that active, voltage-dependent properties of CA3PC dendrites may also promote ensemble functions. Dendritic voltage-dependent ion channels allow nonlinear amplification of spatiotemporally correlated synaptic inputs (such as those produced by ensemble activity) and can even generate local dendritic spikes, which may elicit specific action potential patterns and induce synaptic plasticity. Furthermore, dendritic processing may be modulated by activity-dependent regulation of dendritic ion channels. However, still little is known about the active properties of CA3PC dendrites and their functions during spatial coding or memory tasks. The general aim of my research program is to understand the cellular mechanisms that underlie the formation of hippocampal memory-coding neuronal ensembles. Specifically, we will test the hypothesis that active input integration by dendrites of individual CA3PCs plays an important role in their recruitment into specific context-coding ensembles. By combining in vitro (patch-clamp electrophysiology and two-photon (2P) microscopy in slices) and in vivo (2P imaging and activity-dependent labelling in behaving rodents) approaches, we will provide an in-depth understanding of the dendritic components contributing to the generation of the CA3 ensemble code.

 Publications

year authors and title journal last update
List of publications.
2019 Snezana Raus Balind, Ádám Magó, Mahboobeh Ahmadi, Noémi Kis, Zsófia Varga-Németh, Andrea Lőrincz, Judit K. Makara
Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09767-w
Nature Communications 10/1 2020-02-05
2018 Balázs B. Ujfalussy, Judit K. Makara, Máté Lengyel, Tiago Branco
Global and Multiplexed Dendritic Computations under In Vivo-like Conditions
published pages: 579-592.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.08.032
Neuron 100/3 2020-02-05

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