Opendata, web and dolomites


Molecular-genetic mechanisms of extreme adaptation in a polyphagous agricultural pest

Total Cost €


EC-Contrib. €






 POLYADAPT project word cloud

Explore the words cloud of the POLYADAPT project. It provides you a very rough idea of what is the project "POLYADAPT" about.

crop    global    suggested    hosts    evolution    agriculture    reproduce    crops    bulk    link    polyadapt    evolutionary    underlie    families    quantify    regulators    versus    throughput    assays    pest    bsa    140    molecular    plant    segregant    genome    summary    pests    species    generalists    cis    spider    prior    construct    efficient    hypothesis    poised    resource    elucidate    regulation    interaction    sampled    responsive    validated    rapid    combined    genomic    network    strategies    validation    tools    replicated    tetranychus    functional    resistance    regulatory    loci    experimental    feed    collection    expression    innovative    herbivores    core    causal    variation    map    polyphagous    extreme    generalist    notorious    uncover    urticae    host    adaption    mites    variants    genetic    resistant    pesticide    context    trans    describe    strains    editing    protection    devising    inbred    mechanisms    gene    population    underlying    fundamental    mite    master    create    generate    genes   

Project "POLYADAPT" data sheet

The following table provides information about the project.


Organization address
city: GENT
postcode: 9000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙926˙250 €
 EC max contribution 1˙926˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 1˙926˙250.00


 Project objective

Generalist (polyphagous) herbivores can feed and reproduce on many different plant species and include some of the most pesticide resistant and notorious pests in agriculture. An evolutionary link between host plant range and the development of pesticide resistance has been suggested. Although crucial for devising efficient crop protection strategies, the mechanisms underlying rapid adaptation are not well understood, especially in generalists. The spider mite Tetranychus urticae is a global pest known to feed on 1,100 different hosts from 140 plant families, including most major crops. With experimental advances and new tools developed for T. urticae, we are now poised for fundamental advances in understanding the molecular genetic make-up of adaption in generalist pests. We will generate a large collection of fully inbred and resistant mite strains and describe the sampled genomic variation in the context of selection and adaptation. We will study gene regulation mechanisms and quantify cis versus trans regulation of gene expression on a genome wide scale. We will then create a unique population resource that will allow us to map master regulators of gene expression and construct a gene-regulatory network of adaptation responsive genes. In a highly replicated experimental evolution study, combined with Bulk Segregant Analysis (BSA), we will uncover, without a prior hypothesis, the genomic loci that underlie complex cases of resistance and plant adaptation. A core set of adaptation genes will be validated by functional expression and high-throughput interaction assays. Further validation will come from the development of genome editing tools. In summary, POLYADAPT will exploit the genomic tools now available for spider mites to elucidate regulatory and causal variants underlying the extreme adaptation potential of polyphagous pests. This will in the long term lead to innovative methods of pest management.


year authors and title journal last update
List of publications.
2019 Caleb R. Schlachter, Leily Daneshian, Jose Amaya, Vincent Klapper, Nicky Wybouw, Tomasz Borowski, Thomas Van Leeuwen, Vojislava Grbic, Miodrag Grbic, Thomas M. Makris, Maksymilian Chruszcz
Structural and functional characterization of an intradiol ring-cleavage dioxygenase from the polyphagous spider mite herbivore Tetranychus urticae Koch
published pages: 19-30, ISSN: 0965-1748, DOI: 10.1016/j.ibmb.2018.12.001
Insect Biochemistry and Molecular Biology 107 2020-02-05
2019 Elaheh Shafiei Alavijeh, Jahangir Khajehali, Simon Snoeck, Rafaela Panteleri, Mohammad Ghadamyari, Wim Jonckheere, Sabina Bajda, Corinna Saalwaechter, Sven Geibel, Vassilis Douris, John Vontas, Thomas Van Leeuwen, Wannes Dermauw
Molecular and genetic analysis of resistance to METI-I acaricides in Iranian populations of the citrus red mite Panonychus citri
published pages: , ISSN: 0048-3575, DOI: 10.1016/j.pestbp.2019.12.009
Pesticide Biochemistry and Physiology 2020-02-05
2019 Fariborz Rameshgar, Jahangir Khajehali, Ralf Nauen, Wannes Dermauw, Thomas Van Leeuwen
Characterization of abamectin resistance in Iranian populations of European red mite, Panonychus ulmi Koch (Acari: Tetranychidae)
published pages: 104903, ISSN: 0261-2194, DOI: 10.1016/j.cropro.2019.104903
Crop Protection 125 2020-02-05
2019 Simon Snoeck, Nena Pavlidi, Dimitra Pipini, John Vontas, Wannes Dermauw, Thomas Van Leeuwen
Substrate specificity and promiscuity of horizontally transferred UDP-glycosyltransferases in the generalist herbivore Tetranychus urticae
published pages: 116-127, ISSN: 0965-1748, DOI: 10.1016/j.ibmb.2019.04.010
Insect Biochemistry and Molecular Biology 109 2020-02-05
2019 Peng Wei, Peter Demaeght, Kristof De Schutter, Linda Grigoraki, Vassiliki Labropoulou, Maria Riga, John Vontas, Ralf Nauen, Wannes Dermauw, Thomas Van Leeuwen
Overexpression of an alternative allele of carboxyl/choline esterase 4 (CCE04) of Tetranychus urticae is associated with high levels of resistance to the keto‐enol acaricide spirodiclofen
published pages: , ISSN: 1526-498X, DOI: 10.1002/ps.5627
Pest Management Science 2020-02-05
2019 Evangelia Katsavou, Spyros Vlogiannitis, Eleanor Karp‐Tatham, Damer P Blake, Aris Ilias, Christina Strube, Ilias Kioulos, Wannes Dermauw, Thomas Van Leeuwen, John Vontas
Identification and geographical distribution of pyrethroid resistance mutations in the poultry red mite Dermanyssus gallinae
published pages: 125-133, ISSN: 1526-498X, DOI: 10.1002/ps.5582
Pest Management Science 76/1 2020-02-05
2019 Andre H Kurlovs, Simon Snoeck, Olivia Kosterlitz, Thomas Van Leeuwen, Richard M Clark
Trait mapping in diverse arthropods by bulked segregant analysis
published pages: 57-65, ISSN: 2214-5745, DOI: 10.1016/j.cois.2019.08.004
Current Opinion in Insect Science 36 2020-02-05
2019 Seyedeh Masoumeh Fotoukkiaii, Zoë Tan, Wenxin Xue, Nicky Wybouw, Thomas Van Leeuwen
Identification and characterization of new mutations in mitochondrial cytochrome b that confer resistance to bifenazate and acequinocyl in the spider mite Tetranychus urticae
published pages: , ISSN: 1526-498X, DOI: 10.1002/ps.5628
Pest Management Science 2020-02-05
2019 Simon Snoeck, Andre H. Kurlovs, Sabina Bajda, René Feyereisen, Robert Greenhalgh, Ernesto Villacis-Perez, Olivia Kosterlitz, Wannes Dermauw, Richard M. Clark, Thomas Van Leeuwen
High-resolution QTL mapping in Tetranychus urticae reveals acaricide-specific responses and common target-site resistance after selection by different METI-I acaricides
published pages: 19-33, ISSN: 0965-1748, DOI: 10.1016/j.ibmb.2019.04.011
Insect Biochemistry and Molecular Biology 110 2020-02-05
2019 Nicky Wybouw, Olivia Kosterlitz, Andre H. Kurlovs, Sabina Bajda, Robert Greenhalgh, Simon Snoeck, Huyen Bui, Astrid Bryon, Wannes Dermauw, Thomas Van Leeuwen, Richard M. Clark
Long-Term Population Studies Uncover the Genome Structure and Genetic Basis of Xenobiotic and Host Plant Adaptation in the Herbivore Tetranychus urticae
published pages: 1409-1427, ISSN: 0016-6731, DOI: 10.1534/genetics.118.301803
Genetics 211/4 2020-02-05
2019 Emre İnak, Yasin Nazım Alpkent, Sultan Çobanoğlu, Wannes Dermauw, Thomas Van Leeuwen
Resistance incidence and presence of resistance mutations in populations of Tetranychus urticae from vegetable crops in Turkey
published pages: 343-360, ISSN: 0168-8162, DOI: 10.1007/s10493-019-00398-w
Experimental and Applied Acarology 78/3 2020-02-05
2019 Fariborz Rameshgar, Jahangir Khajehali, Ralf Nauen, Sabina Bajda, Wim Jonckheere, Wannes Dermauw, Thomas Van Leeuwen
Point mutations in the voltage-gated sodium channel gene associated with pyrethroid resistance in Iranian populations of the European red mite Panonychus ulmi
published pages: 80-87, ISSN: 0048-3575, DOI: 10.1016/j.pestbp.2019.03.008
Pesticide Biochemistry and Physiology 157 2020-02-05
2019 Nicky Wybouw, Andre H. Kurlovs, Robert Greenhalgh, Astrid Bryon, Olivia Kosterlitz, Yuki Manabe, Masahiro Osakabe, John Vontas, Richard M. Clark, Thomas Van Leeuwen
Convergent evolution of cytochrome P450s underlies independent origins of keto-carotenoid pigmentation in animals
published pages: 20191039, ISSN: 0962-8452, DOI: 10.1098/rspb.2019.1039
Proceedings of the Royal Society B: Biological Sciences 286/1907 2020-02-05

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