EU H2020 Project "EFHHBBBMS (Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls..)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/214145/index.html
-1	/open-h2020/projects/225250/index.html
-2	/open-h2020/projects/225472/index.html
-3	/open-h2020/projects/213153/index.html
-4	/open-h2020/projects/209781/index.html
-5	/open-h2020/per-coordinator/ch/global+data+excellence+sa/index.html
-6	/open-h2020/projects/225733/index.html

EFHHBBBMS project word cloud

Explore the words cloud of the EFHHBBBMS project. It provides you a very rough idea of what is the project "EFHHBBBMS" about.

regulation neuroscience inserm career conferences opportunity point imaging inflammatory protein multiple campus setting communicate secondment umr copenhagen autocrine pathophysiology requiring seminars junctions audience soon rewarding offers therapies postdoctoral neurovascular collaborations resolution ultimately structure status blood united ll unpublished programs prevent expansion vivo join photon hedgehog international hosting visits exceptional transgenic nedergaard u1034 turning neurocampus 2017 leader barrier msca co molecules return lesion deep young mice me tools week university relapses vascular disseminate brain meetings controls hypothesis original live cells models expertise desert network endothelial microfluidic purpose internationally biology journals gas1 interactions bordeaux vitro receptor signaling intercellular collaborative publications independent dynamic chamber researcher sclerosis bbb fellowship laboratory progression distinguished voluntarily data contributor fruitful choose explorations

Project "EFHHBBBMS" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	173˙076 €
EC max contribution	173˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-01-15 to 2021-01-14

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE	FR (PARIS)	coordinator	173˙076.00

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

FR (PARIS)

coordinator

173˙076.00

Project objective

'Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of 'young leader in neurovascular biology' with an international collaborative network.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EFHHBBBMS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EFHHBBBMS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)