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EFHHBBBMS SIGNED

Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory CentralNervous System lesion size and severity through Gas1 co-receptor modulation.

Total Cost €

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EC-Contrib. €

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Partnership

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 EFHHBBBMS project word cloud

Explore the words cloud of the EFHHBBBMS project. It provides you a very rough idea of what is the project "EFHHBBBMS" about.

me    regulation    controls    explorations    resolution    copenhagen    opportunity    intercellular    journals    2017    ultimately    voluntarily    mice    hosting    u1034    neurocampus    protein    vitro    conferences    setting    desert    inflammatory    requiring    return    communicate    seminars    status    lesion    models    independent    structure    dynamic    collaborations    live    deep    prevent    receptor    co    vascular    fruitful    meetings    laboratory    programs    nedergaard    gas1    hypothesis    cells    chamber    photon    expansion    turning    umr    microfluidic    researcher    inserm    original    join    vivo    brain    soon    signaling    rewarding    imaging    postdoctoral    progression    therapies    international    endothelial    blood    disseminate    expertise    point    molecules    campus    publications    biology    neurovascular    internationally    data    relapses    fellowship    bordeaux    visits    sclerosis    neuroscience    tools    interactions    audience    pathophysiology    barrier    purpose    secondment    unpublished    bbb    msca    ll    university    autocrine    young    united    choose    leader    exceptional    week    transgenic    contributor    multiple    network    distinguished    junctions    hedgehog    career    collaborative    offers   

Project "EFHHBBBMS" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-15   to  2021-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

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 Project objective

'Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of 'young leader in neurovascular biology' with an international collaborative network.'

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The information about "EFHHBBBMS" are provided by the European Opendata Portal: CORDIS opendata.

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