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EFHHBBBMS SIGNED

Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory CentralNervous System lesion size and severity through Gas1 co-receptor modulation.

Total Cost €

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EC-Contrib. €

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Partnership

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 EFHHBBBMS project word cloud

Explore the words cloud of the EFHHBBBMS project. It provides you a very rough idea of what is the project "EFHHBBBMS" about.

mice    u1034    neurovascular    career    setting    umr    gas1    co    collaborations    receptor    journals    status    soon    pathophysiology    young    visits    lesion    week    ll    researcher    return    interactions    bbb    neurocampus    fellowship    vascular    original    meetings    brain    transgenic    inserm    biology    msca    collaborative    hypothesis    inflammatory    imaging    expansion    controls    autocrine    united    neuroscience    voluntarily    chamber    fruitful    requiring    conferences    live    campus    me    network    point    vivo    dynamic    endothelial    relapses    hosting    exceptional    nedergaard    blood    models    secondment    communicate    purpose    contributor    laboratory    bordeaux    seminars    unpublished    disseminate    structure    independent    tools    university    desert    sclerosis    ultimately    vitro    international    distinguished    signaling    microfluidic    therapies    offers    expertise    leader    data    progression    prevent    multiple    molecules    publications    barrier    photon    programs    cells    postdoctoral    internationally    choose    junctions    turning    hedgehog    join    explorations    opportunity    audience    resolution    rewarding    copenhagen    2017    intercellular    protein    regulation    deep   

Project "EFHHBBBMS" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-15   to  2021-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

'Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of 'young leader in neurovascular biology' with an international collaborative network.'

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The information about "EFHHBBBMS" are provided by the European Opendata Portal: CORDIS opendata.

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