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EFHHBBBMS SIGNED

Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory CentralNervous System lesion size and severity through Gas1 co-receptor modulation.

Total Cost €

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EC-Contrib. €

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Partnership

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 EFHHBBBMS project word cloud

Explore the words cloud of the EFHHBBBMS project. It provides you a very rough idea of what is the project "EFHHBBBMS" about.

conferences    week    campus    desert    deep    bbb    independent    vascular    university    programs    blood    purpose    intercellular    autocrine    publications    hypothesis    therapies    ll    postdoctoral    neurovascular    neurocampus    young    mice    journals    molecules    united    expertise    hosting    progression    copenhagen    return    offers    expansion    bordeaux    soon    endothelial    2017    international    controls    opportunity    explorations    communicate    transgenic    seminars    fruitful    requiring    laboratory    gas1    u1034    neuroscience    cells    protein    live    original    point    brain    relapses    biology    junctions    voluntarily    microfluidic    visits    interactions    join    exceptional    inflammatory    signaling    co    dynamic    status    photon    meetings    inserm    turning    unpublished    nedergaard    disseminate    fellowship    contributor    resolution    chamber    prevent    collaborative    hedgehog    choose    rewarding    msca    vivo    receptor    secondment    internationally    collaborations    barrier    sclerosis    lesion    regulation    ultimately    imaging    me    researcher    setting    tools    leader    pathophysiology    vitro    umr    models    multiple    data    structure    audience    career    distinguished    network   

Project "EFHHBBBMS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-15   to  2021-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

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 Project objective

'Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of 'young leader in neurovascular biology' with an international collaborative network.'

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The information about "EFHHBBBMS" are provided by the European Opendata Portal: CORDIS opendata.

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