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EFHHBBBMS SIGNED

Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory CentralNervous System lesion size and severity through Gas1 co-receptor modulation.

Total Cost €

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EC-Contrib. €

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Partnership

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 EFHHBBBMS project word cloud

Explore the words cloud of the EFHHBBBMS project. It provides you a very rough idea of what is the project "EFHHBBBMS" about.

structure    chamber    co    vivo    barrier    signaling    offers    secondment    inflammatory    interactions    exceptional    copenhagen    audience    united    rewarding    intercellular    photon    mice    msca    publications    imaging    hosting    receptor    collaborative    laboratory    endothelial    seminars    sclerosis    biology    point    soon    junctions    relapses    voluntarily    cells    2017    controls    hedgehog    conferences    nedergaard    collaborations    autocrine    dynamic    communicate    neurocampus    postdoctoral    u1034    join    vitro    purpose    setting    turning    choose    requiring    neuroscience    lesion    desert    ultimately    deep    disseminate    contributor    molecules    leader    career    young    blood    therapies    neurovascular    international    journals    regulation    progression    bbb    ll    vascular    return    live    hypothesis    internationally    fellowship    university    microfluidic    programs    visits    brain    bordeaux    fruitful    me    unpublished    campus    network    pathophysiology    expertise    original    gas1    opportunity    distinguished    models    umr    prevent    meetings    week    explorations    expansion    data    tools    independent    inserm    resolution    researcher    multiple    status    transgenic    protein   

Project "EFHHBBBMS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-15   to  2021-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

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 Project objective

'Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of 'young leader in neurovascular biology' with an international collaborative network.'

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