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IRONAGE SIGNED

Iron as a driver of fibrosis and regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IRONAGE project word cloud

Explore the words cloud of the IRONAGE project. It provides you a very rough idea of what is the project "IRONAGE" about.

pluripotency    homeostasis    aging    acquisition    expansion    patients    underlying    vitro    expression    levels    immunity    ion    chronic    mouse    ca2    wound    ongoing    me    significance    bleomycin    acquired    deposition    regeneration    unifying    completely    preliminary    free    last    fibrotic    fundamental    anticipate    divided    tissues    advantage    emphasis    insights    integrate    cytokines    chemokine    cytokine    human    healing    inducer    yield    diverse    iron    worked    background    questions    prevents    data    lung    surprisingly    poorly    manifestations       action    causative    pilot    mice    manuel    cells    models    release    signaling    cellular    senescence    ask    independence       lab    outstanding    maintains    blocks    completion    potent    unexplored    hypothesis    chelation    clinical    inflammation    effect    acute    regulation    serrano    reports    inflammatory    injured    indicate    mechanisms    fibroblasts    transit    indicating    organs    plasticity    expertise       stem    metabolism    local    cancer    channels    follows    fibrosis    accompanied    clearance    found    cation   

Project "IRONAGE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) 

Organization address
address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028
website: www.irbbarcelona.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-05-26

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

'I have worked over the last five years on understanding how ion channels control inflammation, immunity, metabolism and cancer, with a strong emphasis on Ca2 signaling. Now, I would like to take advantage of my diverse background in cation signaling and inflammation and integrate it with the outstanding expertise of Manuel Serrano´s lab in regeneration and aging, to ask fundamental questions on the role of iron in regulation of plasticity and fibrosis. Clinical reports have described local deposition of iron around fibrotic tissues, although the significance of this remains poorly understood and unexplored. My unifying hypothesis is that fibrosis is the manifestations of ongoing free-iron release into injured organs and tissues, which without clearance maintains chronic inflammation and prevents regeneration. The project is divided as follows: Objective #1 – Iron induced inflammation: the impact of free-iron on inflammatory cytokine and chemokine expression and signaling pathways. I have preliminary data indicating that free-iron is a potent inducer of inflammatory cytokines in fibroblasts. Objective #2 – Free-iron as a causative of fibrosis: effect of iron on cellular senescence and on mouse models of fibrosis; and iron homeostasis in human patients with fibrosis. In vitro, I have found that free-iron is an inducer of senescence. Furthermore, in a pilot study, I have found that bleomycin-induced lung fibrosis in mice is accompanied by high levels of iron deposition. Objective #3: Iron clearance and regeneration: Effects of free-iron and iron induced cytokines on acquired plasticity in vitro and on wound healing. Surprisingly, my preliminary data indicate that chelation of free-iron completely blocks acquisition of pluripotency, but has no effect on expansion of stem cells. I anticipate that the completion of this action will yield new fundamental insights into the underlying mechanisms of fibrosis and regeneration, and will allow me the transit to independence.'

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The information about "IRONAGE" are provided by the European Opendata Portal: CORDIS opendata.

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