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IRONAGE SIGNED

Iron as a driver of fibrosis and regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IRONAGE project word cloud

Explore the words cloud of the IRONAGE project. It provides you a very rough idea of what is the project "IRONAGE" about.

clearance    cation    accompanied    diverse    wound    worked    cytokine    integrate    completely    senescence    chelation    underlying    chemokine    poorly    mouse    unexplored    outstanding       yield    human    plasticity    models    cytokines    homeostasis    patients    cells    prevents    advantage    transit    release    serrano       acquisition    chronic    questions    independence    ask    reports    last    free    inflammation    mechanisms    ion    vitro    iron    expression    completion    injured    lung    fibroblasts    me    pluripotency    effect    hypothesis    healing    immunity    blocks    acquired    surprisingly    cancer    local    potent    fundamental    cellular    regeneration    channels       manifestations    aging    bleomycin    fibrotic    indicating    acute    insights    metabolism    mice    maintains    follows    emphasis    ca2    signaling    stem    action    significance    deposition    background    pilot    levels    preliminary    fibrosis    divided    inducer    inflammatory    ongoing    expansion    lab    organs    unifying    indicate    clinical    regulation    causative    found    tissues    expertise    anticipate    manuel    data   

Project "IRONAGE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) 

Organization address
address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028
website: www.irbbarcelona.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-05-26

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

'I have worked over the last five years on understanding how ion channels control inflammation, immunity, metabolism and cancer, with a strong emphasis on Ca2 signaling. Now, I would like to take advantage of my diverse background in cation signaling and inflammation and integrate it with the outstanding expertise of Manuel Serrano´s lab in regeneration and aging, to ask fundamental questions on the role of iron in regulation of plasticity and fibrosis. Clinical reports have described local deposition of iron around fibrotic tissues, although the significance of this remains poorly understood and unexplored. My unifying hypothesis is that fibrosis is the manifestations of ongoing free-iron release into injured organs and tissues, which without clearance maintains chronic inflammation and prevents regeneration. The project is divided as follows: Objective #1 – Iron induced inflammation: the impact of free-iron on inflammatory cytokine and chemokine expression and signaling pathways. I have preliminary data indicating that free-iron is a potent inducer of inflammatory cytokines in fibroblasts. Objective #2 – Free-iron as a causative of fibrosis: effect of iron on cellular senescence and on mouse models of fibrosis; and iron homeostasis in human patients with fibrosis. In vitro, I have found that free-iron is an inducer of senescence. Furthermore, in a pilot study, I have found that bleomycin-induced lung fibrosis in mice is accompanied by high levels of iron deposition. Objective #3: Iron clearance and regeneration: Effects of free-iron and iron induced cytokines on acquired plasticity in vitro and on wound healing. Surprisingly, my preliminary data indicate that chelation of free-iron completely blocks acquisition of pluripotency, but has no effect on expansion of stem cells. I anticipate that the completion of this action will yield new fundamental insights into the underlying mechanisms of fibrosis and regeneration, and will allow me the transit to independence.'

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The information about "IRONAGE" are provided by the European Opendata Portal: CORDIS opendata.

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